Role of membranes in the activities of antimicrobial cationic peptides.

Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

[1]  N. Fujii,et al.  Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2. , 1995, Biochemistry.

[2]  B. de Kruijff,et al.  Membrane activity of the peptide antibiotic clavanin and the importance of its glycine residues. , 2001, Biochemistry.

[3]  E Maier,et al.  Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. , 1999, Biochemistry.

[4]  Y. Shai,et al.  Mode of action of linear amphipathic alpha-helical antimicrobial peptides. , 1998, Biopolymers.

[5]  H. Vogel,et al.  Diversity of antimicrobial peptides and their mechanisms of action. , 1999, Biochimica et biophysica acta.

[6]  P. Axelsen,et al.  Antibacterial and Antimembrane Activities of Cecropin A in Escherichia coli , 2000, Antimicrobial Agents and Chemotherapy.

[7]  R. Hancock,et al.  The role of antimicrobial peptides in animal defenses. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Hancock,et al.  Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria , 2000, Antimicrobial Agents and Chemotherapy.

[9]  R. Hancock,et al.  Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes ofPseudomonas aeruginosa , 2000, Antimicrobial Agents and Chemotherapy.

[10]  R. B. Merrifield,et al.  Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. G. Sawyer,et al.  Interaction of macrophage cationic proteins with the outer membrane of Pseudomonas aeruginosa , 1988, Infection and immunity.

[12]  S. Opella,et al.  Structure and orientation of the antibiotic peptide magainin in membranes by solid‐state nuclear magnetic resonance spectroscopy , 1993, Protein science : a publication of the Protein Society.

[13]  H. Sahl,et al.  Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential , 1996, Infection and immunity.

[14]  Huey W. Huang,et al.  Action of antimicrobial peptides: two-state model. , 2000, Biochemistry.

[15]  R. Hancock,et al.  Interaction of Cationic Antimicrobial Peptides with Model Membranes* , 2001, The Journal of Biological Chemistry.

[16]  H. Engelberg-Kulka,et al.  Programmed Cell Death in Escherichia coli: Some Antibiotics Can Trigger mazEFLethality , 2001, Journal of bacteriology.

[17]  R. Hancock,et al.  Cationic peptides: effectors in innate immunity and novel antimicrobials. , 2001, The Lancet. Infectious diseases.

[18]  R. Hancock,et al.  The bacterial outer membrane as a drug barrier. , 1997, Trends in microbiology.

[19]  S. Natori,et al.  Mode of action of a bactericidal protein induced in the haemolymph of Sarcophaga peregrina (flesh-fly) larvae. , 1984, The Biochemical journal.

[20]  J. Fiddes,et al.  Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity , 1997, Antimicrobial agents and chemotherapy.

[21]  P. S. Mitchell,et al.  The morphological effects of two antimicrobial peptides, hecate-1 and melittin, on Escherichia coli. , 1995, Scanning microscopy.

[22]  S H White,et al.  Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids. , 1997, Biophysical journal.

[23]  T. Ganz,et al.  Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. , 1989, The Journal of clinical investigation.

[24]  R. Hancock,et al.  The role of cationic antimicrobial peptides in innate host defences. , 2000, Trends in microbiology.

[25]  R. Hancock,et al.  Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles. , 2000, Biochemistry.

[26]  K. Matsuzaki,et al.  Magainins as paradigm for the mode of action of pore forming polypeptides. , 1998, Biochimica et biophysica acta.

[27]  P. Axelsen,et al.  Membrane-induced folding of cecropin A. , 2000, Biophysical journal.

[28]  H. G. Boman,et al.  Peptide antibiotics and their role in innate immunity. , 1995, Annual review of immunology.

[29]  T. Ganz,et al.  Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[30]  C. B. Park,et al.  Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: proline as a translocation promoting factor. , 2000, Biochemistry.

[31]  R. Hancock.  Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells. , 1981, The Journal of antimicrobial chemotherapy.

[32]  Y. Shai,et al.  Mode of action of linear amphipathic α-helical antimicrobial peptides , 1998 .