Spatio-temporal analysis of the relationship between climate and 1 Hand , foot , and mouth disease in Shandong Province , China , 2 2008-2012 3 4

4 Yunxia Liu 5 Email: yunxialiu@163.com 6 7 Xianjun Wang 8 Email: xjwang62@163.com 9 10 Chunkun Pang 3 11 Email: ckpang@163.com 12 13 Zhongshang Yuan 1 14 Email: yuanzhongshang@163.com 15 16 Hongkai Li 17 Email: lihongkaiyouxiang@163.com 18 19 Fuzhong Xue 20 Corresponding author 21 Email: xuefzh@sdu.edu.cn 22 23 1 Department of Epidemiology and Biostatistics, School of Public Health, Shandon g University, 24 Jinan, Shandong, China 25 2 Shandong Center for Disease Control and Prevention, Jinan, Shandong, China 26 3 Institute office, Shandong Academy of Medical Science, Jinan, Shandong, China 27

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