In vitro evaluation of copper sulfide nanoparticles decorated with folic acid/chitosan as a novel pH‐sensitive nanocarrier for the efficient controlled targeted delivery of cytarabine as an anticancer drug

Nanoparticles (NPs) have gained more attention as drug delivery systems. Folic acid (FA)‐chitosan (CS) conjugates, because of their biodegradability, low toxicity, and better stability, offer a pharmaceutical drug delivery tool. The aim of this work was to fabricate CuS NPs modified by CS followed by grafting FA as a nanocarrier for the delivery of cytarabine (CYT) as an anticancer drug. In this work, CuS NPs modified by CS and FA were successfully synthesized. The structural properties of the nanocarrier were characterized by using scanning electron microscopy, Fourier transform infrared, X‐ray diffraction, thermogravimetric analysis, and Brunauer–Emmett–Teller. The adsorption mechanism of CYT by adsorption isotherms, kinetics, and thermodynamics was deliberated and modeled. The in vitro CYT release behavior for the nanocarrier was 99% and 61% at pH 5.6 and 7.4, respectively. The adsorption behavior of CYT by CuS NPs–CS–FA was well explored by pseudo–second‐order kinetic and Langmuir isotherm models by the coefficient of determination (R2 > 0.99). Thermodynamic results showed that the uptake of CYT by CuS NPs‐CS‐FA was endothermic and spontaneous. The experimental results showed that CYT/CuS NPs‐CS‐FA can be proposed as an efficient nanocarrier for the targeted delivery of anticancer drugs.

[1]  W. Wang,et al.  Multifunctional inorganic nanomaterials for cancer photoimmunotherapy , 2022, Cancer communications.

[2]  P. ten Dijke,et al.  Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy , 2022, Pharmaceutics.

[3]  G. Pawelec,et al.  Novel immunomodulatory properties of low dose cytarabine entrapped in a mannosylated cationic liposome. , 2021, International journal of pharmaceutics.

[4]  A. Baset,et al.  A comprehensive review of green synthesis of copper oxide nanoparticles and their diverse biomedical applications , 2021 .

[5]  Xinjun Hou,et al.  Chitosan used as a specific coupling agent to modify starch in preparation of adhesive film , 2020 .

[6]  D. Adair,et al.  Morphology and Dimension Variations of Copper Sulfide for High-Performance Electrode in Rechargeable Batteries: A Review , 2020 .

[7]  J. Das,et al.  Tumor targeted delivery of umbelliferone via a smart mesoporous silica nanoparticles controlled-release drug delivery system for increased anticancer efficiency. , 2020, Materials science & engineering. C, Materials for biological applications.

[8]  Zongyu Xie,et al.  Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy , 2020, Journal of Nanobiotechnology.

[9]  D. Das,et al.  Multifunctional Magnetite Nanoparticlesfor Drug Delivery: Preparation, Characterisation, Antibacterial Properties and Drug Release Kinetics. , 2020, International journal of pharmaceutics.

[10]  G. Zehetmeyer,et al.  Chemical and physical properties of nanocrystalline chitosan by the method: Modified nanochitosan complex and process of obtaining modified nanochitosan. , 2020, Carbohydrate research.

[11]  R. Parhi.  Drug delivery applications of chitin and chitosan: a review , 2020, Environmental Chemistry Letters.

[12]  I. Akbarzadeh,et al.  Folate conjugated hyaluronic acid coated alginate nanogels encapsulated oxaliplatin enhance antitumor and apoptosis efficacy on colorectal cancer cells (HT29 cell line). , 2019, Toxicology in vitro : an international journal published in association with BIBRA.

[13]  Z. Selamoğlu,et al.  Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine , 2019, Biomolecules.

[14]  Peng Wang,et al.  Recent Advances in Small Copper Sulfide Nanoparticles for Molecular Imaging and Tumor Therapy. , 2019, Molecular pharmaceutics.

[15]  Jianhua Liu,et al.  Fe-doped copper sulfide nanoparticles for in vivo magnetic resonance imaging and simultaneous photothermal therapy , 2019, Nanotechnology.

[16]  B. Amini,et al.  Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems , 2019, Drug development research.

[17]  H. Karimi-Sari,et al.  Adding Oral Pioglitazone to Standard Induction Chemotherapy of Acute Myeloid Leukemia: A Randomized Clinical Trial , 2019, Clinical lymphoma, myeloma & leukemia.

[18]  H. Jalilian,et al.  Synthesis and characterization of magnetized-PEGylated dendrimer anchored to thermosensitive polymer for letrozole drug delivery. , 2019, Colloids and surfaces. B, Biointerfaces.

[19]  X. Liu,et al.  Doxorubicin-Loaded CuS Nanoparticles Conjugated with GFLG: A Novel Drug Delivery System for Lymphoma Treatment , 2019, Nano.

[20]  J. Beaudoin,et al.  Co-delivery of paclitaxel and cisplatin in poly(2-oxazoline) polymeric micelles: Implications for drug loading, release, pharmacokinetics and outcome of ovarian and breast cancer treatments. , 2019, Biomaterials.

[21]  P. McCarron,et al.  Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: An optimisation study , 2018 .

[22]  Ahmad B. Albadarin,et al.  Mechanism analysis of tartrazine biosorption onto masau stones; a low cost by-product from semi-arid regions , 2017, Journal of Molecular Liquids.

[23]  Zhenzhong Zhang,et al.  Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy , 2017, Journal of drug targeting.

[24]  Zhenzhong Zhang,et al.  Copper sulfide nanoparticle-based localized drug delivery system as an effective cancer synergistic treatment and theranostic platform. , 2017, Acta biomaterialia.

[25]  A. Bharti,et al.  Adsorption mechanism of functionalized multi-walled carbon nanotubes for advanced Cu (II) removal , 2017 .

[26]  H. Ahmad panahi,et al.  Magnetic iron oxide nanoparticles grafted N-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples. , 2017, Journal of separation science.

[27]  Seyed Yaser Hashemi,et al.  The study of non-linear kinetics and adsorption isotherm models for Acid Red 18 from aqueous solutions by magnetite nanoparticles and magnetite nanoparticles modified by sodium alginate. , 2016, Water science and technology : a journal of the International Association on Water Pollution Research.

[28]  K. Mansouri,et al.  Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe3O4@SiO2 nanoparticles. , 2016, Colloids and surfaces. B, Biointerfaces.

[29]  K. Ulbrich,et al.  Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies. , 2016, Chemical reviews.

[30]  K. Muralidharan,et al.  Stabilizer free copper sulphide nanostructures for rapid photocatalytic decomposition of rhodamine B , 2015 .

[31]  K. Prabakar,et al.  CuS nano flakes and nano platelets as counter electrode for quantum dots sensitized solar cells , 2014 .

[32]  Xiaoqing Ji,et al.  Cytarabine-AOT catanionic vesicle-loaded biodegradable thermosensitive hydrogel as an efficient cytarabine delivery system. , 2014, International journal of pharmaceutics.

[33]  Li-hui Wang,et al.  Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma. , 2014, International journal of pharmaceutics.

[34]  Wei Lu,et al.  Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles , 2014, ACS nano.

[35]  Debabrata Pradhan,et al.  Controlled synthesis and catalytic activity of copper sulfide nanostructured assemblies with different morphologies. , 2014, ACS applied materials & interfaces.

[36]  Jiarui Huang,et al.  Large scale synthesis of uniform CuS nanotubes by a sacrificial templating method and their application as an efficient photocatalyst , 2013 .

[37]  Ali Khademhosseini,et al.  Biocompatibility of engineered nanoparticles for drug delivery. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[38]  Wei Lu,et al.  Copper sulfide nanoparticles for photothermal ablation of tumor cells. , 2010, Nanomedicine.

[39]  W. D. de Jong,et al.  Drug delivery and nanoparticles: Applications and hazards , 2008, International journal of nanomedicine.

[40]  Jen-Bin Shi,et al.  Synthesis and optical properties of CuS nanowires fabricated by electrodeposition with anodic alumina membrane , 2008 .

[41]  M. Sivakumar,et al.  Nanoparticular Drug Delivery System of Cytarabine Hydrochloride (CTH) for Improved Treatment of Lymphoma , 2007 .

[42]  M. Dubinin,et al.  The Potential Theory of Adsorption of Gases and Vapors for Adsorbents with Energetically Nonuniform Surfaces. , 1960 .

[43]  M. Temkin,et al.  Recent modifications to Langmuir isotherms , 1940 .

[44]  I. Langmuir.  THE ADSORPTION OF GASES ON PLANE SURFACES OF GLASS, MICA AND PLATINUM. , 1918 .