SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

[1]  D. Zips,et al.  Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer , 2018, Front. Immunol..

[2]  G. Kristiansen,et al.  CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia , 2017, Virchows Archiv.

[3]  F. Buchholz,et al.  Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy , 2016, Clinical and translational radiation oncology.

[4]  M. Quer,et al.  Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma , 2016, European Archives of Oto-Rhino-Laryngology.

[5]  Baosheng Li,et al.  Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma , 2016, Tumor Biology.

[6]  W. Weichert,et al.  Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation. , 2016, European journal of cancer.

[7]  D. Zips,et al.  BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells , 2016, Oncotarget.

[8]  D. Aust,et al.  Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(−) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG , 2016, Clinical Cancer Research.

[9]  M. Baumann,et al.  Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma , 2015, Oncotarget.

[10]  Adam Byron,et al.  Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity , 2015, Cell.

[11]  S. Scala Molecular Pathways: Targeting the CXCR4–CXCL12 Axis—Untapped Potential in the Tumor Microenvironment , 2015, Clinical Cancer Research.

[12]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[13]  H. Weng,et al.  CXCR4 over-expression and survival in cancer: A system review and meta-analysis , 2014, Oncotarget.

[14]  V. Budach,et al.  HPV in , 2014 .

[15]  J. Harrison,et al.  CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment , 2014, Front. Cell. Neurosci..

[16]  A. Dubrovska,et al.  CXCR4 as biomarker for radioresistant cancer stem cells , 2014, International journal of radiation biology.

[17]  E. Raymond,et al.  Focus on the role of the CXCL12/CXCR4 chemokine axis in head and neck squamous cell carcinoma , 2013, Head & neck.

[18]  Derek S. Chan,et al.  Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer , 2013, Proceedings of the National Academy of Sciences.

[19]  A. Dubrovska,et al.  Emerging targets in cancer management: role of the CXCL12/CXCR4 axis , 2013, OncoTargets and therapy.

[20]  D. Banerjee,et al.  P53 regulates the migration of mesenchymal stromal cells in response to the tumor microenvironment through both CXCL12-dependent and -independent mechanisms , 2013, International journal of oncology.

[21]  C. Umbreit,et al.  SDF-1-CXCR4 axis: cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma. , 2013, Oncology reports.

[22]  Yan Cui,et al.  Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid-like stromal network. , 2013, Cancer research.

[23]  D. Schultz,et al.  Functional effects of SDF-1α on a CD44(+) CXCR4(+) squamous cell carcinoma cell line as a model for interactions in the cancer stem cell niche. , 2013, Oncology reports.

[24]  J. Jung,et al.  Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells , 2013, Oncogene.

[25]  E. Raymond,et al.  Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue. , 2012, Oral oncology.

[26]  S. Hehlgans,et al.  Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling. , 2012, International journal of radiation oncology, biology, physics.

[27]  P. Schultz,et al.  CXCR4 Expression in Prostate Cancer Progenitor Cells , 2012, PloS one.

[28]  Yingying Wu,et al.  RNAi targeting CXCR4 inhibits tumor growth through inducing cell cycle arrest and apoptosis. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[29]  F. Balkwill The chemokine system and cancer , 2012, The Journal of pathology.

[30]  J. Picquenot,et al.  Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma. , 2011, Oral oncology.

[31]  M. Baumann,et al.  Tumour-infiltrating CD11b+ myelomonocytes and response to fractionated irradiation of human squamous cell carcinoma (hSCC) xenografts. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[32]  John S. Condeelis,et al.  Chemotaxis in cancer , 2011, Nature Reviews Cancer.

[33]  A. Magliocco,et al.  CXCR4 Overexpression Is Associated with Poor Outcome in Females Diagnosed with Stage IV Non-small Cell Lung Cancer , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[34]  R. Jain,et al.  CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies? , 2011, Clinical Cancer Research.

[35]  Yingying Wu,et al.  CXCR4 Promotes Oral Squamous Cell Carcinoma Migration and Invasion through Inducing Expression of MMP-9 and MMP-13 via the ERK Signaling Pathway , 2011, Molecular Cancer Research.

[36]  R. Jain,et al.  Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. , 2010, Cancer research.

[37]  Shung-Haur Yang,et al.  Nuclear expression of CXCR4 is associated with advanced colorectal cancer , 2010, International Journal of Colorectal Disease.

[38]  H. Vogel,et al.  Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. , 2010, The Journal of clinical investigation.

[39]  A. Ben-Baruch Site-specific metastasis formation , 2009, Cell adhesion & migration.

[40]  Cun-Yu Wang,et al.  CXCL12/SDF-1α Activates NF-κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex , 2009, International Journal of Oral Science.

[41]  G. Sica,et al.  CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. , 2009, The Journal of thoracic and cardiovascular surgery.

[42]  R. Tollenaar,et al.  Nuclear Localization of CXCR4 Determines Prognosis for Colorectal Cancer Patients , 2008, Cancer Microenvironment.

[43]  E. Prakash,et al.  CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. , 2008, Carcinogenesis.

[44]  Seong-Doo Hong,et al.  CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells. , 2008, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[45]  J. Imura,et al.  Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer , 2008, British Journal of Cancer.

[46]  Chi-Long Chen,et al.  Role of Twist in head and neck carcinoma with lymph node metastasis. , 2008, Anticancer research.

[47]  Z. Chen,et al.  CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. , 2007, Cancer research.

[48]  D. Yin,et al.  [Expression and clinical significance of chemokine receptor 4 in oral squamous cell carcinoma]. , 2007, Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.

[49]  H. Yoshida,et al.  Involvement of an Autocrine Stromal Cell–Derived Factor-1/CXCR4 System on the Distant Metastasis of Human Oral Squamous Cell Carcinoma , 2007, Molecular Cancer Research.

[50]  H. Yoshida,et al.  Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells. , 2006, International journal of oncology.

[51]  M. Weller,et al.  Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-β-dependent HIF-1α-mediated induction of CXCL12 , 2006 .

[52]  V. Budach,et al.  Postoperative concurrent radiochemotherapy versus radiotherapy in high-risk SCCA of the head and neck: Results of the German phase III trial ARO 96-3. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[53]  Qingliang Wang,et al.  The Expression of Functional Chemokine Receptor CXCR4 Is Associated with the Metastatic Potential of Human Nasopharyngeal Carcinoma , 2005, Clinical Cancer Research.

[54]  Y. Harabuchi,et al.  Expression of CXCR4 and Its Down-Regulation by IFN-γ in Head and Neck Squamous Cell Carcinoma , 2005, Clinical Cancer Research.

[55]  T. Bando,et al.  Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma , 2004, Laboratory Investigation.

[56]  S. Zucker,et al.  CXCR4-mediated adhesion and MMP-9 secretion in head and neck squamous cell carcinoma. , 2004, Cancer letters.

[57]  F. Balkwill Cancer and the chemokine network , 2004, Nature Reviews Cancer.

[58]  J. Jacobs,et al.  Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. , 2004, The New England journal of medicine.

[59]  Jacques Bernier,et al.  Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. , 2004, The New England journal of medicine.

[60]  F. Balkwill Chemokine biology in cancer. , 2003, Seminars in immunology.

[61]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[62]  Mechthild Krause,et al.  CD8+ tumour‐infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK‐ROG) , 2016, International journal of cancer.

[63]  T. Beißbarth,et al.  Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma , 2015, Strahlentherapie und Onkologie.

[64]  K. Nakashiro,et al.  CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. , 2006, International journal of oncology.

[65]  M. Weller,et al.  Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. , 2006, Brain : a journal of neurology.

[66]  Y. Harabuchi,et al.  Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck squamous cell carcinoma. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[67]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.