Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization
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Mark Johnson | M. Reith | Aloke K. Dutta | Mark Johnson | Tamara Antonio | Maarten E A Reith | Tamara Antonio | Aloke K Dutta | A. Dutta
[1] Aloke K. Dutta,et al. Novel D3 dopamine receptor‐preferring agonist D‐264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine and lactacystin , 2010, Journal of neuroscience research.
[2] Maurizio Recanatini,et al. Multi-target-directed ligands to combat neurodegenerative diseases. , 2008, Journal of medicinal chemistry.
[3] K. Jellinger,et al. The Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease , 1991, Journal of neuropathology and experimental neurology.
[4] M. Martres,et al. [Gene cloning of human dopaminergic D3 receptor and identification of its chromosome]. , 1990, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.
[5] D. Accili,et al. Structural Organization of the Murine D3 Dopamine Receptor Gene , 1995, Journal of neurochemistry.
[6] S. Przedborski,et al. Oxidative Stress in Parkinson's Disease , 2008, Annals of the New York Academy of Sciences.
[7] J. Joyce,et al. Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain: Comparison with D2 Receptor Expressing Neurons , 1999, Neuropsychopharmacology.
[8] M. Millan,et al. S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole , 2004, Journal of Pharmacology and Experimental Therapeutics.
[9] Todd B. Sherer,et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.
[10] Philip Seeman,et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine , 1991, Nature.
[11] T. Sherer,et al. Pathogenesis of Parkinson's disease. , 2001, Current opinion in investigational drugs.
[12] J. Andersen,et al. Dopamine D2/D3 Agonists with Potent Iron Chelation, Antioxidant and Neuroprotective Properties: Potential Implication in Symptomatic and Neuroprotective Treatment of Parkinson’s Disease , 2011, ChemMedChem.
[13] M. Reith,et al. Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity. , 2008, Journal of medicinal chemistry.
[14] C. Chignell,et al. Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations. , 1997, Free radical biology & medicine.
[15] Bruno Giros,et al. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics , 1990, Nature.
[16] M. Mouradian. Recent advances in the genetics and pathogenesis of Parkinson disease , 2002, Neurology.
[17] M G Spillantini,et al. Alpha-synuclein in Lewy bodies. , 1997, Nature.
[18] M. Reith,et al. Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. , 2010, Journal of medicinal chemistry.
[19] A. Carlsson,et al. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists , 1957, Nature.
[20] P. Strange. New insights into dopamine receptors in the central nervous system , 1993, Neurochemistry International.
[21] P. O'Suilleabhain. Movement Disorders: Neurologic Principles and Practice , 1997 .
[22] J. Kebabian,et al. Multiple receptors for dopamine , 1979, Nature.
[23] M. Reith,et al. Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors. , 2004, Bioorganic & medicinal chemistry.
[24] Susan R. George,et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 , 1991, Nature.
[25] Robert R Luedtke,et al. N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity. , 2011, Journal of medicinal chemistry.
[26] V. Menon,et al. Antioxidant activity of an aminothiazole compound: possible mechanisms. , 2008, Chemico-biological interactions.
[27] N. Hattori,et al. [Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease]. , 2004, Rinsho shinkeigaku = Clinical neurology.
[28] S. Cragg,et al. Dopamine receptors--physiological understanding to therapeutic intervention potential. , 1999, Pharmacology & therapeutics.
[29] D. Grandy,et al. Cloning of the cDNA and gene for a human D2 dopamine receptor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[30] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[31] H. Shertzer,et al. Molecular modeling parameters predict antioxidant efficacy of 3-indolyl compounds , 1996, Archives of Toxicology.
[32] T. Dawson,et al. Molecular Pathways of Neurodegeneration in Parkinson's Disease , 2003, Science.
[33] M. Reith,et al. Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. , 2009, Bioorganic & medicinal chemistry.
[34] Daewoo Lee,et al. Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein. , 2007, The European journal of neuroscience.
[35] J. D. Parkes,et al. "ON-OFF" EFFECTS IN PATIENTS WITH PARKINSON'S DISEASE ON CHRONIC LEVODOPA THERAPY , 1976, The Lancet.
[36] Andrew B West,et al. Molecular pathophysiology of Parkinson's disease. , 2005, Annual review of neuroscience.
[37] Peter Gmeiner,et al. The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects. , 2006, Pharmacology & therapeutics.
[38] D. Grandy,et al. Molecular diversity of the dopamine receptors. , 1993, Annual review of pharmacology and toxicology.
[39] Bruce A. Yankner,et al. Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease , 2002, Nature Medicine.
[40] A. Bindoli,et al. Biochemical and toxicological properties of the oxidation products of catecholamines. , 1992, Free radical biology & medicine.
[41] M. Reith,et al. Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. , 2008, Journal of medicinal chemistry.
[42] Daewoo Lee,et al. Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by α‐synuclein , 2007 .
[43] R. Mccall,et al. Sumanirole, a Highly Dopamine D2-Selective Receptor Agonist: In Vitro and in Vivo Pharmacological Characterization and Efficacy in Animal Models of Parkinson's Disease , 2005, Journal of Pharmacology and Experimental Therapeutics.
[44] M. Reith,et al. Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkins , 2010, Journal of medicinal chemistry.
[45] D. Sulzer,et al. Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons , 2009, Neuron.
[46] B. Patil,et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. , 2007, Bioorganic & medicinal chemistry.