Preliminary randomized controlled trial of antiaging effects of l‐ascorbic acid applied in combination with no‐needle and microneedle mesotherapy

The epidermis is keratinized stratified squamous epithelium covered by hydro‐lipid barrier. Vitamin C is a water‐soluble antioxidant which protects skin from oxidative damage and rejuvenates photo‐aged skin. There are different options of improving active substance penetration through the stratum corneum of the epidermis. One of them is noneedle mesotherapy which is a non‐invasive rejuvenation technique involving electric pulses, electroporation, and ultrasounds. The use of these physicals factors results in deeper penetration of active ingredients. The other one is micro‐needle mesotherapy which is nonsurgical therapy, which could cause the controlled inflammation. Micro channels are formed by needles during the skin puncture, that facilitate penetration of the active ingredients.