The potential of 3D printing in urological research and patient care

3D printing is an evolving technology that enables the creation of unique organic and inorganic structures with high precision. In urology, the technology has demonstrated potential uses in both patient and clinician education as well as in clinical practice. The four major techniques used for 3D printing are inkjet printing, extrusion printing, laser sintering, and stereolithography. Each of these techniques can be applied to the production of models for education and surgical planning, prosthetic construction, and tissue bioengineering. Bioengineering is potentially the most important application of 3D printing, as the ability to produce functional organic constructs might, in the future, enable urologists to replicate and replace abnormal tissues with neo-organs, improving patient survival and quality of life.

[1]  A. Megibow,et al.  Renal cell carcinoma: earlier discovery and increased detection. , 1989, Radiology.

[2]  H. Bayley,et al.  High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing , 2017, Scientific Reports.

[3]  Wei Sun,et al.  Effects of Dispensing Pressure and Nozzle Diameter on Cell Survival from Solid Freeform Fabrication–Based Direct Cell Writing , 2008 .

[4]  C. Baird,et al.  The pilot study. , 2000, Orthopedic nursing.

[5]  Eric D. Miller,et al.  Engineered spatial patterns of FGF-2 immobilized on fibrin direct cell organization. , 2005, Biomaterials.

[6]  Trevor Coward,et al.  An In-Vitro Study , 2016 .

[7]  Fabien Guillemot,et al.  Cell patterning technologies for organotypic tissue fabrication. , 2011, Trends in biotechnology.

[8]  Ulrich S Schubert,et al.  Inkjet printing as a deposition and patterning tool for polymers and inorganic particles. , 2008, Soft matter.

[9]  I. Gill,et al.  Three-dimensional Printed Model of Prostate Anatomy and Targeted Biopsy-proven Index Tumor to Facilitate Nerve-sparing Prostatectomy. , 2016, European urology.

[10]  M. Colina,et al.  DNA deposition through laser induced forward transfer. , 2005, Biosensors & bioelectronics.

[11]  Miguel Srougi,et al.  The Use of Three-dimensional Printers for Partial Adrenalectomy: Estimating the Resection Limits. , 2016, Urology.

[12]  A. Lowman,et al.  Hydrogels for the repair of articular cartilage defects. , 2011, Tissue engineering. Part B, Reviews.

[13]  Anthony Atala,et al.  Biomaterials for Integration with 3-D Bioprinting , 2014, Annals of Biomedical Engineering.

[14]  G. Collura,et al.  Primary obstructive megaureter in infants: our experience with endoscopic balloon dilation and cutting balloon ureterotomy. , 2015, Journal of endourology.

[15]  Bulent Sacak,et al.  Use of Rapid Prototyping in Prosthetic Auricular Restoration , 2009, The Journal of craniofacial surgery (Print).

[16]  Russell Y. Neches,et al.  Distributed under Creative Commons Cc-by 4.0 on the Intrinsic Sterility of 3d Printing , 2022 .

[17]  Jong-Hyun Lee,et al.  Anti-Reflux Ureteral Stent with Polymeric Flap Valve Using Three-Dimensional Printing: An In Vitro Study. , 2015, Journal of endourology.

[18]  M. Słojewski,et al.  Low cost silicone renal replicas for surgical training - technical note. , 2016, Archivos espanoles de urologia.

[19]  Renai Yoon,et al.  Development and initial porcine and cadaver experience with three-dimensional printing of endoscopic and laparoscopic equipment. , 2015, Journal of endourology.

[20]  David G. Armstrong,et al.  Three-dimensional printing surgical instruments: are we there yet? , 2014, The Journal of surgical research.

[21]  B. Derby,et al.  Delivery of human fibroblast cells by piezoelectric drop-on-demand inkjet printing. , 2008, Biomaterials.

[22]  Rocky S Tuan,et al.  Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. , 2013, Biomaterials.

[23]  S. Van Vlierberghe,et al.  Bioink properties before, during and after 3D bioprinting , 2016, Biofabrication.

[24]  James J. Yoo,et al.  A 3D bioprinting system to produce human-scale tissue constructs with structural integrity , 2016, Nature Biotechnology.

[25]  M. Sugimoto,et al.  Patient-specific 3-dimensional Printed Kidney Designed for "4D" Surgical Navigation: A Novel Aid to Facilitate Minimally Invasive Off-clamp Partial Nephrectomy in Complex Tumor Cases. , 2016, Urology.

[26]  Development and Initial Porcine and Cadaver Experience with Three-Dimensional Printing of Endoscopic and Laparoscopic Equipment , 2015 .

[27]  Le Xie,et al.  A novel computer‐assisted drill guide template for lumbar pedicle screw placement: a cadaveric and clinical study , 2009, The international journal of medical robotics + computer assisted surgery : MRCAS.

[28]  R. Link,et al.  Utility of patient‐specific silicone renal models for planning and rehearsal of complex tumour resections prior to robot‐assisted laparoscopic partial nephrectomy , 2017, BJU international.

[29]  Adrian Neagu,et al.  Three-dimensional tissue constructs built by bioprinting. , 2006, Biorheology.

[30]  Raj Satkunasivam,et al.  Personalized 3D printed model of kidney and tumor anatomy: a useful tool for patient education , 2016, World Journal of Urology.

[31]  Efthymios Maneas,et al.  From medical imaging data to 3D printed anatomical models , 2017, PloS one.

[32]  C. Alberti,et al.  Three-dimensional CT and structure models. , 1980, The British journal of radiology.

[33]  Eric D. Miller,et al.  Microenvironments Engineered by Inkjet Bioprinting Spatially Direct Adult Stem Cells Toward Muscle‐ and Bone‐Like Subpopulations , 2008, Stem cells.

[34]  Stuart K Williams,et al.  Direct-write bioprinting three-dimensional biohybrid systems for future regenerative therapies. , 2011, Journal of biomedical materials research. Part B, Applied biomaterials.

[35]  Costas Fotakis,et al.  Directed three-dimensional patterning of self-assembled peptide fibrils. , 2008, Nano letters.

[36]  James J. Yoo,et al.  Tissue-engineered autologous urethras for patients who need reconstruction: an observational study , 2011, The Lancet.

[37]  Jing Hu,et al.  Computer-Aided Design and Manufacturing and Rapid Prototyped Nanoscale Hydroxyapatite/Polyamide (n-HA/PA) Construction for Condylar Defect Caused by Mandibular Angle Ostectomy , 2011, Aesthetic Plastic Surgery.

[38]  H. Ford,et al.  My Life and Work , 1922 .

[39]  S. Takayama,et al.  Rapid generation of multiplexed cell cocultures using acoustic droplet ejection followed by aqueous two-phase exclusion patterning. , 2012, Tissue engineering. Part C, Methods.

[40]  G. Aldinger,et al.  Computer-aided manufacture of individual endoprostheses , 1983, Archives of orthopaedic and traumatic surgery.

[41]  H. Fischer,et al.  Direct Inkjet Printing of Dental Prostheses Made of Zirconia , 2009, Journal of dental research.

[42]  Robert T. Chang,et al.  3D Printed Smartphone Indirect Lens Adapter for Rapid, High Quality Retinal Imaging , 2014 .

[43]  Anthony Atala,et al.  Tissue-engineered autologous vaginal organs in patients: a pilot cohort study , 2014, The Lancet.

[44]  Mika Salmi,et al.  Possibilities of Preoperative Medical Models Made by 3D Printing or Additive Manufacturing , 2016, Journal of medical engineering.

[45]  Shuichi Matsuda,et al.  Developing a novel custom cutting guide for curved peri-acetabular osteotomy , 2013, International Orthopaedics.

[46]  Anthony Atala,et al.  3D bioprinting of urethra with PCL/PLCL blend and dual autologous cells in fibrin hydrogel: An in vitro evaluation of biomimetic mechanical property and cell growth environment. , 2017, Acta biomaterialia.

[47]  Zhixia Li,et al.  Current progress in inorganic artificial biomaterials , 2011, Journal of Artificial Organs.

[48]  F. Altunrende,et al.  Impact of Three-Dimensional Printed Pelvicaliceal System Models on Residents' Understanding of Pelvicaliceal System Anatomy Before Percutaneous Nephrolithotripsy Surgery: A Pilot Study. , 2016, Journal of endourology.

[49]  Tao Xu,et al.  Viability and electrophysiology of neural cell structures generated by the inkjet printing method. , 2006, Biomaterials.

[50]  Anthony Atala,et al.  3D bioprinting of tissues and organs , 2014, Nature Biotechnology.

[51]  Michael M. Maddox,et al.  Individualized Physical 3-dimensional Kidney Tumor Models Constructed From 3-dimensional Printers Result in Improved Trainee Anatomic Understanding. , 2015, Urology.