Detection of Ascorbic Acid Using Green Synthesized Carbon Quantum Dots

In this work, carbon quantum dots (CQDs) were synthesized by microwave irradiation and were electropolymerized on glassy carbon electrode (GCE) to establish an electrochemical sensor for the selective detection of ascorbic acid (AA). Electrochemical behaviors of the prepared sensor were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Herein, two wide linear responses were obtained in ranges of 0.01-3 mM and 4-12 mM with a low detection limit of 10 μM to AA. High sensitivities (44.13 μA-1 μM-1 cm-2, 9.66 μA-1 μM-1 cm-2, respectively) corresponding to the linear ranges were also achieved. In addition, the electrochemical sensor exhibited good selectivity and robust anti-interference ability toward AA in the presence of dopamine (DA) and uric acid (UA). These results showed that this sensor can be used as a promising tool to detect AA in real complex systems.

[1]  I. B. Agater,et al.  Direct chemiluminescence determination of ascorbic acid using flow injection analysis , 1997 .

[2]  Zhang Yan,et al.  A novel electrochemical ascorbic acid sensor based on branch-trunk Ag hierarchical nanostructures , 2018 .

[3]  M. Ghomi,et al.  Green synthesized carbon quantum dots from Prosopis juliflora leaves as a dual off-on fluorescence probe for sensing mercury (II) and chemet drug. , 2019, Materials science & engineering. C, Materials for biological applications.

[4]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[5]  P. He,et al.  Zeolite A functionalized with copper nanoparticles and graphene oxide for simultaneous electrochemical determination of dopamine and ascorbic acid. , 2012, Analytica chimica acta.

[6]  Yi Lin,et al.  Reduced graphene oxide-carbon dots composite as an enhanced material for electrochemical determination of dopamine , 2014 .

[7]  Shunxing Li,et al.  Nitrogen and sulfur co-doped carbon dots synthesis via one step hydrothermal carbonization of green alga and their multifunctional applications , 2019, Microchemical Journal.

[8]  Wei Wang,et al.  3D graphene foams decorated by CuO nanoflowers for ultrasensitive ascorbic acid detection. , 2014, Biosensors & bioelectronics.

[9]  M. Liu,et al.  A stable sandwich-type amperometric biosensor based on poly(3,4-ethylenedioxythiophene)–single walled carbon nanotubes/ascorbate oxidase/nafion films for detection of L-ascorbic acid , 2011 .

[10]  A. Tiwari,et al.  Graphene nanoplatelets-silver nanorods-polymer based in-situ hybrid electrode for electroanalysis of dopamine and ascorbic acid in biological samples , 2017, Applied Surface Science.

[11]  C. Huang,et al.  Carbon dots synthesized at room temperature for detection of tetracycline hydrochloride. , 2019, Analytica chimica acta.

[12]  Yixiang Cheng,et al.  Microwave-assisted preparation of N-doped carbon dots as a biosensor for electrochemical dopamine detection. , 2015, Journal of colloid and interface science.

[13]  P. Jorge,et al.  Hg(II) sensing based on functionalized carbon dots obtained by direct laser ablation , 2010 .

[14]  J. Qin,et al.  Gold nanorods decorated with graphene oxide and multi-walled carbon nanotubes for trace level voltammetric determination of ascorbic acid , 2018, Microchimica Acta.

[15]  Yuchan Zhang,et al.  Copper Nanowires Modified with Graphene Oxide Nanosheets for Simultaneous Voltammetric Determination of Ascorbic Acid, Dopamine and Acetaminophen , 2019, Molecules.

[16]  Hong Zhao,et al.  A highly sensitive and selective detection of Cr(VI) and ascorbic acid based on nitrogen-doped carbon dots. , 2018, Talanta.

[18]  Shouzhuo Yao,et al.  A quadruplet electrochemical platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a ferrocene derivative functional Au NPs/carbon dots nanocomposite and graphene. , 2016, Analytica chimica acta.

[19]  O. Arrigoni,et al.  Ascorbic acid: much more than just an antioxidant. , 2002, Biochimica et biophysica acta.

[20]  Hui Huang,et al.  Carbon Dots: A Small Conundrum , 2019, Trends in Chemistry.

[21]  Liangliang Huang,et al.  Surface N-doped graphene sheets induced high electrocatalytic activity for selective ascorbic acid sensing , 2019, Sensors and Actuators B: Chemical.

[22]  Xinhong Song,et al.  Fluorescence sensing of chromium (VI) and ascorbic acid using graphitic carbon nitride nanosheets as a fluorescent "switch". , 2015, Biosensors & bioelectronics.

[23]  Inamuddin,et al.  Multiwalled carbon nanotube-based nanosensor for ultrasensitive detection of uric acid, dopamine, and ascorbic acid. , 2019, Materials science & engineering. C, Materials for biological applications.

[24]  R. Hughes Vitamin C in Health and Disease , 1982 .

[25]  Shen-ming Chen,et al.  In situ assembly of sulfur-doped carbon quantum dots surrounded iron(III) oxide nanocomposite; a novel electrocatalyst for highly sensitive detection of antipsychotic drug olanzapine , 2018, Journal of Molecular Liquids.

[26]  Fan Yang,et al.  Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties. , 2009, Chemical communications.

[27]  X. Hou,et al.  Preparation of flake hexagonal BN and its application in electrochemical detection of ascorbic acid, dopamine and uric acid , 2018 .

[28]  X. Hou,et al.  Electrochemical detection mechanism of dopamine and uric acid on titanium nitride-reduced graphene oxide composite with and without ascorbic acid , 2019, Sensors and Actuators B: Chemical.

[29]  Hai Wu,et al.  An electrochemical sensor based on a porphyrin dye-functionalized multi-walled carbon nanotubes hybrid for the sensitive determination of ascorbic acid , 2019, Journal of Electroanalytical Chemistry.

[30]  W. Shin,et al.  Hydroquinone modified chitosan/carbon film electrode for the selective detection of ascorbic acid. , 2013, Carbohydrate polymers.

[31]  Yen Wei,et al.  A one-step ultrasonic irradiation assisted strategy for the preparation of polymer-functionalized carbon quantum dots and their biological imaging. , 2018, Journal of colloid and interface science.

[32]  Linsen Huang,et al.  Study on the fluorescence properties of carbon dots prepared via combustion process , 2019, Journal of Luminescence.

[33]  Lintao Zeng,et al.  Ultrasensitive near-infrared fluorescence-enhanced probe for discriminative detection of GSH and Cys from different emission channels , 2017 .

[34]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[35]  S. Jeon,et al.  A highly stable and sensitive GO-XDA-Mn2O3 electrochemical sensor for simultaneous electrooxidation of paracetamol and ascorbic acid , 2017 .

[36]  A. E. Al-Salami,et al.  Silver nanoparticles decorated stain-etched mesoporous silicon for sensitive, selective detection of ascorbic acid , 2019, Materials Letters.

[37]  T. Rao,et al.  Individual and simultaneous electrochemical determination of metanil yellow and curcumin on carbon quantum dots based glassy carbon electrode. , 2018, Materials science & engineering. C, Materials for biological applications.

[38]  Bingrong Wang,et al.  Rapid synthesis of Cu2O/CuO/rGO with enhanced sensitivity for ascorbic acid biosensing , 2017 .

[39]  M. Shamsipur,et al.  A glassy carbon electrode modified with carbon quantum dots and polyalizarin yellow R dyes for enhanced electrocatalytic oxidation and nanomolar detection of l-cysteine , 2017 .

[40]  W. Marsden I and J , 2012 .

[41]  E. J. Oliveira,et al.  Chromatographic techniques for the determination of putative dietary anticancer compounds in biological fluids. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[42]  Dongxue Han,et al.  Hierarchical bi-continuous Pt decorated nanoporous Au-Sn alloy on carbon fiber paper for ascorbic acid, dopamine and uric acid simultaneous sensing. , 2019, Biosensors & bioelectronics.

[43]  Chang Yu,et al.  Solvothermal conversion of coal into nitrogen-doped carbon dots with singlet oxygen generation and high quantum yield , 2017 .

[44]  Manash R. Das,et al.  Cu-Ag bimetallic nanoparticles on reduced graphene oxide nanosheets as peroxidase mimic for glucose and ascorbic acid detection , 2017 .

[45]  Hao Chen,et al.  A green and effective corrosion inhibitor of functionalized carbon dots , 2019, Journal of Materials Science & Technology.

[46]  Fengchun Yang,et al.  An electrochemical biosensor for ascorbic acid based on carbon-supported PdNi nanoparticles. , 2013, Biosensors & bioelectronics.

[47]  Shaojun Dong,et al.  Ultrathin Pd nanowire as a highly active electrode material for sensitive and selective detection of ascorbic acid. , 2010, Biosensors & bioelectronics.

[48]  A. Versari,et al.  Rapid analysis of ascorbic and isoascorbic acids in fruit juice by capillary electrophoresis , 2004 .

[49]  C. Huang,et al.  Fluorescent carbon dots functionalization. , 2019, Advances in colloid and interface science.

[50]  M. A. Alonso-Lomillo,et al.  Determination of ascorbic acid in serum samples by screen-printed carbon electrodes modified with gold nanoparticles. , 2017, Talanta.

[51]  Guobao Xu,et al.  Ultrasensitive Glutathione Detection Based on Lucigenin Cathodic Electrochemiluminescence in the Presence of MnO2 Nanosheets. , 2016, Analytical chemistry.

[52]  Wei Xiao,et al.  Sensitive colorimetric detection of ascorbic acid using Pt/CeO2 nanocomposites as peroxidase mimics , 2019, Applied Surface Science.

[53]  Dianyun Zhao,et al.  A highly sensitive and stable electrochemical sensor for simultaneous detection towards ascorbic acid, dopamine, and uric acid based on the hierarchical nanoporous PtTi alloy. , 2016, Biosensors & bioelectronics.

[54]  Jiye Cai,et al.  Constructions of polyaniline nanofiber-based electrochemical sensor for specific detection of nitrite and sensitive monitoring of ascorbic acid scavenging nitrite , 2012 .

[55]  M. Ajmal,et al.  Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid , 2019, Microchimica Acta.

[56]  J. Koenderink Q… , 2014, Les noms officiels des communes de Wallonie, de Bruxelles-Capitale et de la communaute germanophone.

[57]  X. Su,et al.  A novel turn-on fluorescent strategy for sensing ascorbic acid using graphene quantum dots as fluorescent probe. , 2017, Biosensors & bioelectronics.

[58]  Sushmee Badhulika,et al.  Facile green synthesis of reduced graphene oxide/tin oxide composite for highly selective and ultra-sensitive detection of ascorbic acid , 2018 .

[59]  Kai Fan,et al.  Plasma-assisted synthesis of carbon fibers/ZnO core–shell hybrids on carbon fiber templates for detection of ascorbic acid and uric acid , 2016 .

[60]  D. Bouchta,et al.  Electrochemical detection of uric acid and ascorbic acid: Application in serum , 2015 .

[61]  N. Sahiner,et al.  Carbon dots: preparation, properties, and application , 2019, Nanocarbon and its Composites.

[62]  X. Hou,et al.  Simultaneously electrochemical detection of uric acid and ascorbic acid using glassy carbon electrode modified with chrysanthemum-like titanium nitride , 2017 .

[63]  Y. Zu,et al.  Simultaneous detection of ascorbic acid and uric acid using a fluorosurfactant-modified platinum electrode , 2007 .