Computational modeling of the EGF-receptor system: a paradigm for systems biology.
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[1] H. Steven Wiley,et al. A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands , 1981, Cell.
[2] H. Wiley,et al. The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. , 1982, The Journal of biological chemistry.
[3] H. Wiley,et al. Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface , 1982, Journal of cellular biochemistry.
[4] C DeLisi,et al. Receptor-mediated endocytosis: a model and its implications for experimental analysis. , 1984, The American journal of physiology.
[5] H. Wiley,et al. Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system. , 1984, The Journal of biological chemistry.
[6] H. Wiley,et al. Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions. , 1985, The Journal of biological chemistry.
[7] A. Ullrich,et al. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing , 1987, Cell.
[8] H. Wiley,et al. Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system , 1988, The Journal of cell biology.
[9] A. Ullrich,et al. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body , 1990, Cell.
[10] H. Wiley,et al. Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization. , 1990, The Journal of biological chemistry.
[11] J. Welsh,et al. Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. , 1990, Science.
[12] D A Lauffenburger,et al. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. , 1991, The Journal of biological chemistry.
[13] J. Kao,et al. Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor. , 1991, The Journal of biological chemistry.
[14] D A Lauffenburger,et al. Autocrine ligand binding to cell receptors. Mathematical analysis of competition by solution "decoys". , 1992, Biophysical journal.
[15] G. Carpenter,et al. Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism , 1992, Journal of cellular physiology.
[16] D A Lauffenburger,et al. Mathematical Model for the Effects of Epidermal Growth Factor Receptor Trafficking Dynamics on Fibroblast Proliferation Responses , 1992, Biotechnology progress.
[17] K Lund,et al. Implications of epidermal growth factor (EGF) induced egf receptor aggregation. , 1992, Biophysical journal.
[18] J. Tainer,et al. Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. , 1993, The Journal of biological chemistry.
[19] D. Lauffenburger,et al. Receptors: Models for Binding, Trafficking, and Signaling , 1993 .
[20] D. Lauffenburger,et al. Proliferative Response of Fibroblasts Expressing Internalization‐Deficient Epidermal Growth Factor (EGF) Receptors Is Altered via Differential EGF Depletion Effect , 1994, Biotechnology progress.
[21] D. Lauffenburger,et al. Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor. , 1995, Tissue engineering.
[22] D A Lauffenburger,et al. Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction (*) , 1995, The Journal of Biological Chemistry.
[23] H. Wiley,et al. Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain (*) , 1995, The Journal of Biological Chemistry.
[24] Alan Wells,et al. Engineering epidermal growth factor for enhanced mitogenic potency , 1996, Nature Biotechnology.
[25] M. Nugent,et al. Basic Fibroblast Growth Factor Binds Its Receptors, Is Internalized, and Stimulates DNA Synthesis in Balb/c3T3 Cells in the Absence of Heparan Sulfate* , 1996, The Journal of Biological Chemistry.
[26] J. Baselga,et al. Autocrine Regulation of Membrane Transforming Growth Factor- Cleavage (*) , 1996, The Journal of Biological Chemistry.
[27] D A Lauffenburger,et al. Analysis of receptor internalization as a mechanism for modulating signal transduction. , 1998, Journal of theoretical biology.
[28] B. Geiger,et al. Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency* , 1998, The Journal of Biological Chemistry.
[29] D. Stern,et al. Specificity within the EGF family/ErbB receptor family signaling network , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.
[30] D A Lauffenburger,et al. Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[31] R. Schmidt-Ullrich,et al. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. , 1999, Molecular biology of the cell.
[32] H. Wiley,et al. Human mammary epithelial cells rapidly exchange empty EGFR between surface and intracellular pools , 1999, Journal of cellular physiology.
[33] D. Ingber,et al. The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading* , 1999, The Journal of Biological Chemistry.
[34] P. Sternberg,et al. Multiple positive and negative regulators of signaling by the EGF-receptor. , 1999, Current opinion in cell biology.
[35] R. Schmidt-Ullrich,et al. Molecular mechanisms of radiation-induced accelerated repopulation. , 1999, Radiation oncology investigations.
[36] U. Bhalla,et al. Emergent properties of networks of biological signaling pathways. , 1999, Science.
[37] D. Lauffenburger,et al. Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21 ras in Fibroblasts* , 1999, The Journal of Biological Chemistry.
[38] D. Lauffenburger,et al. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[39] A. Wells. EGF receptor. , 1999, The international journal of biochemistry & cell biology.
[40] B. Kholodenko,et al. Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.
[41] H. Wiley,et al. ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors* , 1999, The Journal of Biological Chemistry.
[42] G. Carpenter. The EGF receptor: a nexus for trafficking and signaling , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.
[43] H. Wiley,et al. Trafficking and Proteolytic Release of Epidermal Growth Factor Receptor Ligands Are Modulated by Their Membrane-anchoring Domains* , 2000, The Journal of Biological Chemistry.
[44] G. Carpenter. EGF Receptor Transactivation Mediated by the Proteolytic Production of EGF-like Agonists , 2000, Science's STKE.
[45] Douglas A. Lauffenburger,et al. Increased Endosomal Sorting of Ligand to Recycling Enhances Potency of an Interleukin-2 Analog* , 2000, The Journal of Biological Chemistry.
[46] P. Dent,et al. Ionizing Radiation-Induced Mitogen-Activated Protein (MAP) Kinase Activation in DU145 Prostate Carcinoma Cells: MAP Kinase Inhibition Enhances Radiation-Induced Cell Killing and G2/M-Phase Arrest , 2000 .
[47] H. Wiley,et al. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. , 2001, Molecular biology of the cell.
[48] H. Steven Wiley,et al. Regulation of Receptor Tyrosine Kinase Signaling by Endocytic Trafficking , 2001, Traffic.
[49] R. Schmidt-Ullrich,et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. , 2001, Journal of the National Cancer Institute.
[50] D. Lauffenburger,et al. Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration , 2001, The Journal of cell biology.
[51] Y. Yarden,et al. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases , 2001, FEBS letters.
[52] D A Lauffenburger,et al. Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. , 2001, Journal of cell science.
[53] D A Lauffenburger,et al. Spatial range of autocrine signaling: modeling and computational analysis. , 2001, Biophysical journal.
[54] D. Lauffenburger,et al. Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching” , 2002, Nature Biotechnology.
[55] L. E. Johannessen,et al. Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies , 2002, The Journal of cell biology.
[56] D. Lauffenburger,et al. Autocrine loops with positive feedback enable context-dependent cell signaling. , 2002, American journal of physiology. Cell physiology.
[57] M. Martin-Fernandez,et al. Preformed oligomeric epidermal growth factor receptors undergo an ectodomain structure change during signaling. , 2002, Biophysical journal.
[58] J. Doyle,et al. Reverse Engineering of Biological Complexity , 2002, Science.
[59] Douglas A Lauffenburger,et al. Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. , 2002, Development.
[60] E. Gilles,et al. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors , 2002, Nature Biotechnology.
[61] A. Sorkin,et al. Effect of Tyrosine Kinase Inhibitors on Clathrin-coated Pit Recruitment and Internalization of Epidermal Growth Factor Receptor* , 2002, The Journal of Biological Chemistry.
[62] H. Kitano. Systems Biology: A Brief Overview , 2002, Science.
[63] D. Lauffenburger,et al. Affinity regulates spatial range of EGF receptor autocrine ligand binding. , 2002, Developmental biology.
[64] Edouard C. Nice,et al. Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α , 2002, Cell.
[65] M. Freeman,et al. Control of EGF Receptor Signalling: Lessons from Fruitflies , 2004, Cancer and Metastasis Reviews.
[66] Y. Sugiyama,et al. Receptor-Mediated Transport of Peptide Hormones and Its Importance in the Overall Hormone Disposition in the Body , 1989, Pharmaceutical Research.