Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice.

[1]  Mohammed Akbar,et al.  Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress , 2021, Antioxidants.

[2]  G. Bandara,et al.  Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation , 2021, Nature Communications.

[3]  R. Omelka,et al.  Pharmacological agents and natural compounds: available treatments for osteoporosis. , 2020, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[4]  Sung Ryul Lee,et al.  Anti-osteoporotic effects of Salvia miltiorrhiza Bunge EtOH extract both in ovariectomized and naturally menopausal mouse models. , 2020, Journal of ethnopharmacology.

[5]  M. Conese,et al.  Biological properties and therapeutic effects of plant-derived nanovesicles , 2020, Open medicine.

[6]  J. Niu,et al.  ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles. , 2019, Journal of hepatology.

[7]  Bin Gao,et al.  Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1‐Mediated Oxidative and Nitrative Stress , 2019 .

[8]  Jiujiu Yu,et al.  Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation. , 2019, Molecular pharmaceutics.

[9]  Ling Zhou,et al.  Astragalin Promotes Osteoblastic Differentiation in MC3T3-E1 Cells and Bone Formation in vivo , 2019, Front. Endocrinol..

[10]  K. Kang,et al.  Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A , 2019, Nature Communications.

[11]  S. Rome.  Biological properties of plant-derived extracellular vesicles. , 2019, Food & function.

[12]  Sang-Hyun Kim,et al.  Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice , 2018, Scientific Reports.

[13]  G. Bandara,et al.  Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation , 2018, Proceedings of the National Academy of Sciences.

[14]  Mohammed Akbar,et al.  Extracellular vesicles as potential biomarkers for alcohol‐ and drug‐induced liver injury and their therapeutic applications , 2018, Pharmacology & therapeutics.

[15]  Ming Wang,et al.  Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes , 2018, Science.

[16]  E. Schwarz,et al.  Osteoblast–osteoclast interactions , 2018, Connective tissue research.

[17]  Xiaofeng Zhu,et al.  Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[18]  Young-Eun Cho,et al.  Increased ethanol‐inducible cytochrome P450‐2E1 and cytochrome P450 isoforms in exosomes of alcohol‐exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress , 2017, Hepatology communications.

[19]  D. Merlin,et al.  Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis. , 2017, Nanomedicine.

[20]  J. Suttles,et al.  Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[21]  Tümay Sözen,et al.  An overview and management of osteoporosis. , 2017, European journal of rheumatology.

[22]  M. Baek,et al.  Increased liver-specific proteins in circulating extracellular vesicles as potential biomarkers for drug- and alcohol-induced liver injury , 2017, PloS one.

[23]  Soo Jin Kim,et al.  Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4‐MD2 for Efficient LPS Recognition and Transfer , 2017, Immunity.

[24]  P. Schlesinger,et al.  Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro. , 2016, Tissue engineering. Part B, Reviews.

[25]  F. Claessens,et al.  Estrogens and Androgens in Skeletal Physiology and Pathophysiology. , 2017, Physiological reviews.

[26]  S. Jay,et al.  Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications , 2017, The AAPS Journal.

[27]  Huan Wang,et al.  Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy. , 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

[28]  In‐San Kim,et al.  Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer , 2016, Oncotarget.

[29]  Bo Chen,et al.  Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation. , 2016, Life sciences.

[30]  In‐San Kim,et al.  Identification of EDIL3 on extracellular vesicles involved in breast cancer cell invasion. , 2016, Journal of proteomics.

[31]  In‐San Kim,et al.  Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection , 2015, Clinical Cancer Research.

[32]  Q. Mei,et al.  Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2/MAPK/Smad-dependent Runx2 pathway. , 2015, Molecular medicine reports.

[33]  S. Raimondo,et al.  Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death , 2015 .

[34]  C. McClain,et al.  Ginger-derived nanoparticles protect against alcohol-induced liver damage , 2015, Journal of extracellular vesicles.

[35]  Hong Liu,et al.  High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio , 2014, International journal of molecular sciences.

[36]  Hong Jiang,et al.  Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. , 2014, Molecular nutrition & food research.

[37]  Hong Jiang,et al.  Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  Huijun Sun,et al.  Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines , 2014, Journal of Biomedical Science.

[39]  Xiu-zhen Zhang,et al.  Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation. , 2013, European journal of pharmacology.

[40]  R. Welti,et al.  Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[41]  Hong Jiang,et al.  Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids , 2013, Nature Communications.

[42]  H. Sohn,et al.  Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. , 2011, The Journal of nutritional biochemistry.

[43]  T. Rachner,et al.  Osteoporosis: now and the future , 2011, The Lancet.

[44]  I. Kwun,et al.  Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells , 2010, Nutrition research and practice.

[45]  M. Valenti,et al.  Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management , 2010, Drug, healthcare and patient safety.

[46]  Jui-Sheng Sun,et al.  Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[47]  A. Abou-Samra,et al.  Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation. , 2010, Cellular signalling.

[48]  Je-Yong Choi,et al.  Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation. , 2010, Bone.

[49]  T. Uemura,et al.  Bone regeneration induced by adenoviral vectors carrying til‐1/Cbfa1 genes implanted with biodegradable porous materials in animal models of osteonecrosis of the femoral head , 2008, Journal of tissue engineering and regenerative medicine.

[50]  L. Raisz.  Pathogenesis of osteoporosis: concepts, conflicts, and prospects. , 2005, The Journal of clinical investigation.

[51]  M. Bouxsein,et al.  Ovariectomy‐Induced Bone Loss Varies Among Inbred Strains of Mice , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[52]  Ann Cranney,et al.  Benefit-Risk Assessment of Raloxifene in Postmenopausal Osteoporosis , 2005, Drug safety.

[53]  P. Knaus,et al.  Signal transduction of bone morphogenetic protein receptors. , 2004, Cellular signalling.

[54]  Angela J. Shepherd.  An overview of osteoporosis. , 2004, Alternative therapies in health and medicine.

[55]  J. Lemonnier,et al.  Activation of p38 Mitogen‐Activated Protein Kinase and c‐Jun‐NH2‐Terminal Kinase by BMP‐2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[56]  Nikitas Sykaras,et al.  Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? , 2003, Journal of oral science.

[57]  T. Jia,et al.  Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. , 2003, Biochemical pharmacology.

[58]  S. Bae,et al.  Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein , 2002, Oncogene.

[59]  F. Lallemand,et al.  Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. , 2001, Bone.

[60]  E. Wang,et al.  Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. , 1991, Biochemical and biophysical research communications.

[61]  A. Parfitt.  The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. , 1982, Metabolic bone disease & related research.