Correlation of intrinsic DNA curvature with DNA property periodicity

Twelve di‐ and trinucleotide parameter sets representing various structural, thermodynamic or bendability‐related properties of DNA were tested in the prediction of DNA curvature applying Fourier analysis on curved and straight, A/T‐type or G/C‐type DNA sequence motifs. The best predictions were obtained with a new consensus bendability scale created by combining a nucleosome‐based and a deoxyribonuclease I‐based parameter set. Geometry calculations on the same sequences showed that the helical parameters derived from NMR structures can correctly predict curvature, as distinct from the parameters derived from X‐ray crystallographic analysis.

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