论文信息 - Optical Resolution of Phenylalanine and Mandelic Acid by Complex Formation with Copper(II) Ion

Optical Resolution of Phenylalanine and Mandelic Acid by Complex Formation with Copper(II) Ion

The optical resolutions of phenylalanine and mandelic acid were performed by complex formation with Cu2+. D- and L-mandelic acids were completely resolved by forming a complex with L-phenylalanine, while the maximum optical purity of D- and L-phenylalanine by using D-mandelic acid was about 65%. The mole ratio of Cu2+ to phenylalanine and/or mandelic acid in the complexes was 0.5. These results were interpreted in terms of the relative stability of the complexes, i.e., the optical absorption energies in the aqueous media.

H. Yamashita | Yasushi Yamamoto | T. Maekawa | S. Kato

[1] T. Murakami,et al. Stabilities of the Copper(II) Complexes with Quadridentate Derivatives of L-Prolinamide and L-Proline Methylamide , 1986 .

[2] P. E. Hare,et al. Resolution of underivatized amino acids by reversed-phase chromatography , 1980 .

[3] T. Murakami,et al. New nickel(II) complexes of some optically active tetraamines with pyrrolidinyl groups , 1975 .

[4] T. Wagler,et al. Synthesis of a chiral dioxo-cyclam derived from L-phenylalanine and its application to olefin oxidation chemistry , 1988 .

[5] N. Kuroki,et al. Asymmetric Interaction between Mandelic Acid and Aromatic α-Amino Acids in Aqueous System , 1971 .