Simple Controlled Release Delivery System for an Anti-hypertensive Drug via Buccal Route

Objective: This study aims to develop controlled release buccal tablets of losartan potassium based on bioadhesion using direct compression technique. Materials and Methods: The bioadhesive buccal tablets of losartan potassium were prepared after preliminary drug -excipients compatibility studies and micromeretics study for powder blends. The tablets were prepared by direct compression utilizing carbopol 934LR as a primary bioadhesive polymer either with or without chitosan or hydroxypropyl methylcellulose E15LV as secondary polymers. Other excipients included PVP K30 as a binder, magnesium stearate as a lubricant and mannit ol as a diluent. The tablets were evaluated for weight variation, thickness and diameter, hardness, friability, drug content, surface pH,Ex-vivoresidence time and bioadhesion force,In-vitroswelling anddrug release study.The analysis of the release pr ofiles in the light of distinct kinetic models

[1]  P. Srinivas,et al.  FORMULATION AND IN VITRO EVALUATION OF LOSARTAN POTASSIUM MUCOADHESIVE BUCCAL TABLETS , 2013 .

[2]  Pharmaceutical Press,et al.  Handbook of Pharmaceutical Excipients , 2012 .

[3]  Faiza Qureshi,et al.  Spectroscopic study to characterize in vitro interaction of losartan with gliquidone and pioglitazone , 2012, Medicinal Chemistry Research.

[4]  P. R. Veerareddy,et al.  Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Tizanidine Hydrochloride Tablets , 2009, AAPS PharmSciTech.

[5]  A. Healy,et al.  Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties. , 2009, International journal of pharmaceutics.

[6]  D. Bhowmik.  Fast Dissolving Tablet: An Overview , 2009 .

[7]  Sudhir V. Pandya,et al.  Development and In-vitro Evaluation of Mucoadhesive Buccal Tablets of Domperidone , 2008 .

[8]  A. Healy,et al.  Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[9]  B. Prajapati,et al.  Mucoadhesive bilayer tablets of propranolol hydrochloride , 2007, AAPS PharmSciTech.

[10]  B. Prajapati,et al.  Formulation, evaluation, and comparison of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride , 2007, AAPS PharmSciTech.

[11]  C. Kolli,et al.  Development and in vitro evaluation of buccoadhesive carvedilol tablets , 2007, Acta pharmaceutica.

[12]  M. Pk,et al.  Entrapment of andrographolide in cross-linked alginate pellets: I. Formulation and evaluation of associated release kinetics. , 2007, Pakistan journal of pharmaceutical sciences.

[13]  M. Pk,et al.  Entrapment of andrographolide in cross-linked alginate pellets: II. Physicochemical characterization to study the pelletization of andrographolide. , 2007, Pakistan journal of pharmaceutical sciences.

[14]  E. Mahmoud,et al.  Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation. , 2006, International journal of pharmaceutics.

[15]  T. M. Kumar,et al.  Novel core in cup buccoadhesive systems and fi lms of terbutaline sulphate-development and in vitro evaluation , 2006 .

[16]  M. Jug,et al.  Influence of hydroxypropyl-beta-cyclodextrin complexation on piroxicam release from buccoadhesive tablets. , 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[17]  Xiaoling Li,et al.  Transbuccal Delivery of Acyclovir: I. In Vitro Determination of Routes of Buccal Transport , 1998, Pharmaceutical Research.

[18]  M. Hussain,et al.  Thermal Analysis and Solution Calorimetry Studies on Losartan Polymorphs , 1993, Pharmaceutical Research.

[19]  P. Tayade,et al.  Encapsulation of water-insoluble drug by a cross-linking technique: effect of process and formulation variables on encapsulation efficiency, particle size, and in vitro dissolution rate. , 2004, AAPS pharmSci.

[20]  AC Moffat,et al.  Clarke's analysis of drugs and poisons , 2003 .

[21]  J. Varshosaz,et al.  Development and characterization of buccoadhesive nifedipine tablets. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[22]  Vijay Kumar,et al.  Preparation, characterization, and tabletting properties of a new cellulose-based pharmaceutical aid. , 2002, International journal of pharmaceutics.

[23]  H. Choi,et al.  Development of omeprazole buccal adhesive tablets with stability enhancement in human saliva. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[24]  J. Reid,et al.  Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension. , 1997, Pharmacology & therapeutics.

[25]  S. Agarwal,et al.  Preparation and evaluation of bioerodible buccal tablets containing clotrimazole , 1996 .

[26]  T. Nagai,et al.  In vitro and in vivo nasal mucoadhesion of some water-soluble polymers , 1996 .

[27]  R. Khar,et al.  Measurement of bioadhesive strength of muco-adhesive buccal tablets: design of an in-vitro assembly , 1993 .

[28]  Nicholas A. Peppas,et al.  A simple equation for description of solute release II. Fickian and anomalous release from swellable devices , 1987 .

[29]  N. Peppas,et al.  Mechanisms of solute release from porous hydrophilic polymers , 1983 .

[30]  Joseph L. Kanig,et al.  The theory and practice of industrial pharmacy , 1970 .

[31]  S. H. Fox.  The Theory and Practice of Industrial Pharmacy , 1970 .