Drug delivery dressings

Abstract: This chapter concerns the targeted and sustained topical delivery of therapeutic agents to chronic wounds using natural and synthetic polymer carriers. It outlines the role of drug delivery dressings in wound management and focuses on the delivery of antimicrobials and growth factors to facilitate the healing process. Using the established dressing categories of hydrocolloids, hydrogels, collagen and alginates, it reviews recent research, limiting discussion to combinations of polymer and therapeutic agent. Traditional dressings composed of cotton wool, lint, natural or synthetic bandages and gauzes are only discussed in terms of secondary dressings for the primary dressings of interest.

[1]  T. Roth,et al.  Effects of calcium alginate on cellular wound healing processes modeled in vitro. , 1996, Journal of biomedical materials research.

[2]  A. Metters,et al.  Hydrogels in controlled release formulations: network design and mathematical modeling. , 2006, Advanced drug delivery reviews.

[3]  M. Timm,et al.  Immunomodulatory effects of honey cannot be distinguished from endotoxin. , 2008, Cytokine.

[4]  A. Schuermans,et al.  Comparison of free and bound iodine and iodide species as a function of the dilution of three commercial povidone-iodine formulations and their microbicidal activity. , 2006, International journal of pharmaceutics.

[5]  H. Y. Kim,et al.  Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone). , 2006, Journal of biomedical materials research. Part A.

[6]  P. K. Sehgal,et al.  Collagen bilayer dressing with ciprofloxacin, an effective system for infected wound healing , 2007, Journal of biomaterials science. Polymer edition.

[7]  D. G. Armstrong,et al.  Wound Microbiology and Associated Approaches to Wound Management , 2001, Clinical Microbiology Reviews.

[8]  J. Boateng,et al.  Wound healing dressings and drug delivery systems: a review. , 2008, Journal of pharmaceutical sciences.

[9]  W. Lyoo,et al.  Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate. , 2008, Biological & pharmaceutical bulletin.

[10]  D. Morgan WOUND MANAGEMENT PRODUCTS IN THE DRUG TARIFF , 1999 .

[11]  David S. Jones,et al.  Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[12]  D. Brett A discussion of silver as an antimicrobial agent: alleviating the confusion. , 2006, Ostomy/wound management.

[13]  D. M. Cooper,et al.  Determination of Endogenous Cytokines in Chronic Wounds , 1994, Annals of surgery.

[14]  L. Ovington,et al.  Advances in wound dressings. , 2007, Clinics in dermatology.

[15]  Leaf Huang,et al.  Thermosensitive Hydrogel as a Tgf-β1 Gene Delivery Vehicle Enhances Diabetic Wound Healing , 2003, Pharmaceutical Research.

[16]  I. K. Cohen,et al.  The Role of Macrophages in Wound Repair: A Review , 1981, Plastic and reconstructive surgery.

[17]  E. A. Nelson,et al.  Dressings for healing venous leg ulcers. , 2014, The Cochrane database of systematic reviews.

[18]  Jong-Chul Park,et al.  An infection-preventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles: physical and biological properties. , 2002, Artificial organs.

[19]  A. Lansdown Zinc in the healing wound , 1996, The Lancet.

[20]  Baljit Singh,et al.  Development of sterculia gum based wound dressings for use in drug delivery , 2008 .

[21]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[22]  P. Tewes-Schwarzer MANUFACTURING PRINCIPLES OF FREEZE-DRIED COLLAGEN SPONGES : CHARACTERISTICS AND APPLICATIONS , 1999 .

[23]  R. Cooper,et al.  An investigation into the wound healing potential of Welsh honeys , 2008 .

[24]  E. Muhl,et al.  Release of Vancomycin and Teicoplanin from a Plasticized and Resorbable Gelatin Sponge: in Vitro Investigation of a New Antibiotic Delivery System with Glycopeptides , 2006, Infection.

[25]  S. Fujii,et al.  Critical evaluation of cadexomer-iodine ointment and povidone-iodine sugar ointment. , 2009, International journal of pharmaceutics.

[26]  Bing Chen,et al.  Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin , 2008, Journal of Molecular Medicine.

[27]  N. Occleston,et al.  A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. , 2003, Journal of medicinal chemistry.

[28]  Wayne R. Gombotz,et al.  The Enhancement in Wound Healing by Transforming Growth Factor-β1 (TGF-β1) Depends on the Topical Delivery System , 1995 .

[29]  Diarmaid J. Murphy,et al.  Modulation of gel formation and drug-release characteristics of lidocaine-loaded poly(vinyl alcohol)-tetraborate hydrogel systems using scavenger polyol sugars. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[30]  O. Chosidow,et al.  Dressings for acute and chronic wounds: a systematic review. , 2007, Archives of dermatology.

[31]  F. Silver,et al.  Effects of fibroblasts and basic fibroblast growth factor on facilitation of dermal wound healing by type I collagen matrices. , 1991, Journal of biomedical materials research.

[32]  S. Murphree,et al.  Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. , 2007, American journal of surgery.

[33]  M. Spraul,et al.  Prospective randomized controlled study of Hydrofiber® dressing containing ionic silver or calcium alginate dressings in non‐ischaemic diabetic foot ulcers , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[34]  R. Kirsner,et al.  Antiseptics on Wounds: An Area of Controversy , 2003 .

[35]  I. Cangul,et al.  Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits. , 2006, Veterinary dermatology.

[36]  K. Matthews,et al.  Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. , 2008, International journal of pharmaceutics.

[37]  N. Medlicott,et al.  Hypromellose films for the delivery of growth factors for wound healing , 2007, The Journal of pharmacy and pharmacology.

[38]  D. Armstrong,et al.  Pain in diabetic foot ulcers. , 2003, Ostomy/wound management.

[39]  S. Ueng,et al.  In vitro elution of antibiotic from antibiotic-impregnated biodegradable calcium alginate wound dressing. , 1999, The Journal of trauma.

[40]  Hong Shen,et al.  The immobilization of basic fibroblast growth factor on plasma-treated poly(lactide-co-glycolide). , 2008, Biomaterials.

[41]  A. Lansdown,et al.  Zinc in wound healing: Theoretical, experimental, and clinical aspects , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[42]  J. Leroux,et al.  In situ-forming hydrogels--review of temperature-sensitive systems. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[43]  Major George Blaine EXPERIMENTAL OBSERVATIONS ON ABSORBABLE ALGINATE PRODUCTS IN SURGERY* , 1947, Annals of surgery.

[44]  Hwal Suh,et al.  Evaluation of antibiotic-loaded collagen-hyaluronic acid matrix as a skin substitute. , 2004, Biomaterials.

[45]  Emir Baki Denkbaş,et al.  Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material , 2006 .

[46]  K. Matthews,et al.  Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier. , 2005, International journal of pharmaceutics.

[47]  R. Burrell,et al.  Impact of heat on nanocrystalline silver dressings. Part I: Chemical and biological properties. , 2005, Biomaterials.

[48]  J. Grzybowski,et al.  New cytokine dressings. I. Kinetics of the in vitro rhG-CSF, rhGM-CSF, and rhEGF release from the dressings. , 1999, International journal of pharmaceutics.

[49]  C. Wiegand,et al.  Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver‐containing alginate , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[50]  Gabriela A Silva,et al.  Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. , 2007, Advanced drug delivery reviews.

[51]  S. Uma,et al.  Design and delivery of silver sulfadiazine from alginate microspheres-impregnated collagen scaffold. , 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

[52]  K. Harding,et al.  Wound management and dressings , 2019, Advanced Textiles for Wound Care.

[53]  H. Hierlemann,et al.  Stimulation of steroid-suppressed cutaneous healing by repeated topical application of IGF-I: different mechanisms of action based upon the mode of IGF-I delivery. , 2007, The Journal of surgical research.

[54]  P. Nair,et al.  Poly(methyl methacrylate)-grafted chitosan microspheres for controlled release of ampicillin. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[55]  Bishara S Atiyeh,et al.  Effect of silver on burn wound infection control and healing: review of the literature. , 2007, Burns : journal of the International Society for Burn Injuries.

[56]  A. Henriques,et al.  Free radical production and quenching in honeys with wound healing potential. , 2006, The Journal of antimicrobial chemotherapy.

[57]  P. K. Sehgal,et al.  Improved collagen bilayer dressing for the controlled release of drugs. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[58]  Jing-Ran Wu,et al.  Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies , 2005, Journal of materials science. Materials in medicine.

[59]  P. Molan The Evidence Supporting the Use of Honey as a Wound Dressing , 2006, The international journal of lower extremity wounds.

[60]  A. Molassiotis,et al.  A systematic review of honey uses and its potential value within oncology care. , 2008, Journal of clinical nursing.

[61]  Kyle Kleinbeck,et al.  Concurrent In Vitro Release of Silver Sulfadiazine and Bupivacaine From Semi-Interpenetrating Networks for Wound Management , 2009, Journal of burn care & research : official publication of the American Burn Association.

[62]  A. Stroock,et al.  An active wound dressing for controlled convective mass transfer with the wound bed. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[63]  P. Molan,et al.  The Effect of Gamma‐irradiation on the Antibacterial Activity of Honey , 1996, The Journal of pharmacy and pharmacology.

[64]  M. Y. Arica,et al.  Preparation and drug-release behavior of minocycline-loaded poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)–methacrylate] films , 2009 .

[65]  Leaf Huang,et al.  Intradermal Injection of Transforming Growth Factor-β1 Gene Enhances Wound Healing in Genetically Diabetic Mice , 2003, Pharmaceutical Research.

[66]  M. F. Ginani,et al.  Mechanical properties and release studies of chitosan films impregnated with silver sulfadiazine , 2006 .

[67]  G R Tobin,et al.  Physiology and healing dynamics of chronic cutaneous wounds. , 1998, American journal of surgery.

[68]  W. Lyoo,et al.  Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. , 2008, International journal of pharmaceutics.

[69]  H. Chang,et al.  Characterization of PVA/glycerin hydrogels made by γ-irradiation for advanced wound dressings , 2009 .

[70]  K. Ho,et al.  Comment on: Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis. , 2010, The Journal of antimicrobial chemotherapy.

[71]  W. Friess,et al.  Collagen--biomaterial for drug delivery. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[72]  D. Adcock The Effect of Catalase on the Inhibine and Peroxide Values of Various Honeys , 1962 .

[73]  N. Basson,et al.  Antimicrobial activity of two South African honeys produced from indigenous Leucospermum cordifolium and Erica species on selected micro-organisms , 2008, BMC complementary and alternative medicine.

[74]  K. Harding,et al.  Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-alpha. , 2000, Biomaterials.

[75]  D. Holt Management, principles and practices , 1987 .

[76]  Stephen Thomas Hydrocolloid dressings in the management of acute wounds: a review of the literature , 2008, International wound journal.

[77]  W. Ahn,et al.  Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex. , 2008, Biomaterials.

[78]  Miqin Zhang,et al.  Chitosan-based hydrogels for controlled, localized drug delivery. , 2010, Advanced drug delivery reviews.

[79]  A. Mandal,et al.  Application of a PDGF-containing novel gel for cutaneous wound healing. , 2010, Life sciences.

[80]  F. Beghe,et al.  Collagen as a pharmacological approach in wound healing. , 1992, International journal of tissue reactions.

[81]  J. Morgan,et al.  Comparative susceptibility of hospital isolates of gram-negative bacteria to antiseptics and disinfectants. , 1987, The Journal of hospital infection.

[82]  D. Schmaljohann,et al.  Epidermal growth factor therapy and wound healing--past, present and future perspectives. , 2008, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[83]  P. Molan The Antibacterial Activity of Honey: 1. The nature of the antibacterial activity , 1992 .

[84]  T. Kato,et al.  The enhancement of cellular infiltration and vascularisation of a collagenous dermal implant in the rat by platelet-derived growth factor BB. , 1995, Journal of dermatological science.

[85]  B. Sreedhar,et al.  A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. , 2007, Journal of colloid and interface science.

[86]  M. Zilberman,et al.  Antibiotic-eluting medical devices for various applications. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[87]  P. Mertz,et al.  Wound healing microbiology. , 1993, Dermatologic clinics.

[88]  J. Filipović,et al.  Silver(I)-complexes with an itaconic acid-based hydrogel , 2009 .

[89]  G. Gozzi,et al.  VITAMIN E ADDED SILICONE GEL SHEETS FOR TREATMENT OF HYPERTROPHIC SCARS AND KELOIDS , 1995, International journal of dermatology.

[90]  R. Yoshida,et al.  Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: I. Drug release. , 1991, Journal of biomaterials science. Polymer edition.

[91]  L. Chan,et al.  Interactions of antimicrobial compounds with cross-linking agents of alginate dressings. , 2008, The Journal of antimicrobial chemotherapy.

[92]  N. Gheldof,et al.  Identification and quantification of antioxidant components of honeys from various floral sources. , 2002, Journal of agricultural and food chemistry.

[93]  Ae-Ri Cho Lee,et al.  Reversal of silver sulfadiazine-impaired wound healing by epidermal growth factor. , 2005, Biomaterials.

[94]  L. Ovington The truth about silver. , 2004, Ostomy/wound management.

[95]  M. Braun,et al.  [Effects of the zinc oxide and cod liver oil containing ointment Zincojecol in an animal model of wound healing]. , 2006, DTW. Deutsche tierarztliche Wochenschrift.

[96]  A. Lansdown Calcium: a potential central regulator in wound healing in the skin , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[97]  A. Pandit,et al.  The effect of TGF-beta delivered through a collagen scaffold on wound healing. , 1999, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[98]  E. Bradley,et al.  Analysis of Explanted Silicone Implants: A Report of 300 Patients , 1995, Annals of plastic surgery.

[99]  G. Tobin,et al.  Impediments to wound healing. , 1998, American journal of surgery.

[100]  Y. Bae,et al.  Thermosensitive sol-gel reversible hydrogels. , 2002, Advanced drug delivery reviews.

[101]  G. Gethin Commentary on Bardy J, Slevin NJ, Mais KL & Molassiotis A (2008) A systematic review of honey uses and its potential value within oncology care. Journal of Clinical Nursing 17, 2604-2623. , 2008, Journal of clinical nursing.

[102]  David Brett,et al.  A Review of Collagen and Collagen-based Wound Dressings. , 2008, Wounds : a compendium of clinical research and practice.

[103]  B. Godin,et al.  A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: an in vivo study. , 2005, The Journal of antimicrobial chemotherapy.

[104]  R. Fader,et al.  Pharmacokinetics of Topical and Intravenous Cefazolin in Patients with Clean Surgical Wounds , 2008, Plastic and reconstructive surgery.

[105]  R. Duncan,et al.  Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[106]  R. Lim,et al.  Efficacy of a fibrin hemostatic bandage in controlling hemorrhage from experimental arterial injuries. , 1995, Archives of surgery.

[107]  J. Zitelli,et al.  A review of topical agents for wounds and methods of wounding. Guidelines for wound management. , 1993, The Journal of dermatologic surgery and oncology.

[108]  R. Cooper,et al.  The sensitivity to honey of Gram‐positive cocci of clinical significance isolated from wounds , 2002, Journal of applied microbiology.

[109]  Yuan Yuan,et al.  Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control. , 2009, Biomaterials.

[110]  M. Maeda,et al.  Sustained release of human growth hormone (hGH) from collagen film and evaluation of effect on wound healing in db/db mice. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[111]  N. Adhirajan,et al.  Gelatin microspheres cross-linked with EDC as a drug delivery system for doxycyline: Development and characterization , 2007, Journal of microencapsulation.

[112]  F. Mi,et al.  Antibacterial activity of chitosan–alginate sponges incorporating silver sulfadiazine: Effect of ladder-loop transition of interpolyelectrolyte complex and ionic crosslinking on the antibiotic release , 2005 .

[113]  W. Friess,et al.  Collagen as a carrier for on-site delivery of antibacterial drugs. , 2003, Advanced drug delivery reviews.

[114]  M. Babu,et al.  Efficiency of controlled topical delivery of silver sulfadiazine in infected burn wounds. , 2009, Journal of biomedical materials research. Part A.

[115]  A. Seabra,et al.  Nitric oxide donor improves healing if applied on inflammatory and proliferative phase. , 2008, The Journal of surgical research.

[116]  H. Vermeulen,et al.  Topical silver for treating infected wounds. , 2007, The Cochrane database of systematic reviews.

[117]  Chih-Hui Yang Evaluation of the release rate of bioactive recombinant human epidermal growth factor from crosslinking collagen sponges , 2008, Journal of materials science. Materials in medicine.

[118]  Joy Thompson A revision of the genus Leptospermum (Myrtaceae) , 1989 .

[119]  A. Khademhosseini,et al.  Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology , 2006 .

[120]  M. Colić,et al.  The application of collagen sheet in open wound healing*. , 2005, Annals of burns and fire disasters.

[121]  Sha Huang,et al.  Wound dressings containing bFGF-impregnated microspheres , 2006, Journal of microencapsulation.

[122]  J. Kennedy,et al.  The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications. , 2009, Journal of the mechanical behavior of biomedical materials.

[123]  N. Peppas,et al.  Hydrogels in Pharmaceutical Formulations , 1999 .

[124]  A. Simon,et al.  Medical Honey for Wound Care—Still the ‘Latest Resort’? , 2008, Evidence-based complementary and alternative medicine : eCAM.