Viscoelastic properties of the tongue and soft palate using MR elastography.

Biomechanical properties of the human tongue are needed for finite element models of the upper airway and may be important to elucidate the pathophysiology of obstructive sleep apneoa. Tongue viscoelastic properties have not been characterized previously. Magnetic resonance elastography (MRE) is an emerging imaging technique that can measure the viscoelastic properties of soft tissues in-vivo. In this study, MRE was used to measure the viscoelastic properties of the tongue and soft palate in 7 healthy volunteers during quiet breathing. Results show that the storage shear modulus of the tongue and soft palate is 2.67±0.29 and 2.53±0.31 kPa (mean ± SD), respectively. This is the first study to investigate the mechanical properties of the tongue using MRE, and it provides necessary data for future studies of patient groups with altered upper airway function.

[1]  Ralph Sinkus,et al.  In vivo brain viscoelastic properties measured by magnetic resonance elastography , 2008, NMR in biomedicine.

[2]  Chun Xu,et al.  Image-based three-dimensional finite element modeling approach for upper airway mechanics , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[3]  M. Birch,et al.  Biomechanical Properties of the Human Soft Palate , 2009, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[4]  S. Gandevia,et al.  Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. , 2006, Journal of neurophysiology.

[5]  B. V. Van Beers,et al.  Liver fibrosis: non‐invasive assessment with MR elastography , 2006, NMR in biomedicine.

[6]  M Fink,et al.  Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography , 2005, Magnetic resonance in medicine.

[7]  R. Schwab,et al.  Pro: sleep apnea is an anatomic disorder. , 2003, American journal of respiratory and critical care medicine.

[8]  A. Manduca,et al.  Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. , 1995, Science.

[9]  R. M. Harper,et al.  The human tongue during sleep: Electromyographic activity of the genioglossus muscle , 1976, Experimental Neurology.

[10]  Jerry L. Prince,et al.  Motion estimation from tagged MR image sequences , 1992, IEEE Trans. Medical Imaging.

[11]  Abbas Samani,et al.  MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations , 2009, Magnetic resonance in medicine.

[12]  Zachary J. Domire,et al.  Feasibility of using magnetic resonance elastography to study the effect of aging on shear modulus of skeletal muscle. , 2009, Journal of applied biomechanics.

[13]  K. Strohl Con: sleep apnea is not an anatomic disorder. , 2003, American journal of respiratory and critical care medicine.

[14]  P. Perrier,et al.  Simulations of the consequences of tongue surgery on tongue mobility: implications for speech production in post‐surgery conditions , 2007, The international journal of medical robotics + computer assisted surgery : MRCAS.

[15]  Mark E Ladd,et al.  In vivo elasticity measurements of extremity skeletal muscle with MR elastography , 2004, NMR in biomedicine.

[16]  L E Bilston,et al.  Movement of the tongue during normal breathing in awake healthy humans , 2008, The Journal of physiology.

[17]  Thomas Benner,et al.  Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractography , 2007, Journal of magnetic resonance imaging : JMRI.

[18]  Richard L Ehman,et al.  Evaluation of healthy and diseased muscle with magnetic resonance elastography. , 2002, Archives of physical medicine and rehabilitation.

[19]  H. P. Lee,et al.  Snoring source identification and snoring noise prediction. , 2007, Journal of biomechanics.

[20]  Van J. Wedeen,et al.  Anatomical basis of lingual hydrostatic deformation , 2007, Journal of Experimental Biology.

[21]  G W M Peters,et al.  Towards a reliable characterisation of the mechanical behaviour of brain tissue: The effects of post-mortem time and sample preparation. , 2007, Biorheology.

[22]  Hartmut Schneider,et al.  Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. , 2008, Proceedings of the American Thoracic Society.

[23]  David A. Berry,et al.  A Finite Element Model of the Soft Palate , 1999 .

[24]  Mickael Tanter,et al.  MR elastography of breast lesions: Understanding the solid/liquid duality can improve the specificity of contrast‐enhanced MR mammography , 2007, Magnetic resonance in medicine.

[25]  M. GerardJ. Non linear elastic properties of the lingual and facial tissues assessed by indentation technique . Application to the biomechanics of speech production , 2005 .

[26]  Ian Stavness,et al.  Towards predicting biomechanical consequences of jaw reconstruction , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[27]  R. Sinkus,et al.  High-resolution tensor MR elastography for breast tumour detection. , 2000, Physics in medicine and biology.

[28]  G. Adam,et al.  Menstrual-Cycle Dependence of Breast Parenchyma Elasticity: Estimation With Magnetic Resonance Elastography of Breast Tissue During the Menstrual Cycle , 2003, Investigative radiology.

[29]  Ron Kikinis,et al.  The male predisposition to pharyngeal collapse: importance of airway length. , 2002, American journal of respiratory and critical care medicine.