β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
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B. de Strooper | Gerdien E. de Kloe | S. Munck | A. Thathiah | Yunhong Huang | K. Horré | Elke Vandewyer | A. Snellinx | M. Ciesielska
[1] R. Tanzi. The genetics of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[2] D. Scheinberg,et al. Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase* , 2012, The Journal of Biological Chemistry.
[3] Donald A. Wilson,et al. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models , 2012, Science.
[4] A. Ittner,et al. Tau‐targeted treatment strategies in Alzheimer's disease , 2012, British journal of pharmacology.
[5] Y. Shitaka,et al. Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice , 2012, The Journal of Neuroscience.
[6] D. Holtzman,et al. Mapping the Road Forward in Alzheimer’s Disease , 2011, Science Translational Medicine.
[7] D. Selkoe,et al. Resolving controversies on the path to Alzheimer's therapeutics , 2011, Nature Medicine.
[8] B. Strooper,et al. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics , 2011, Nature Reviews Drug Discovery.
[9] R. Lefkowitz,et al. Therapeutic potential of β-arrestin- and G protein-biased agonists. , 2011, Trends in molecular medicine.
[10] B. Strooper,et al. The role of G protein-coupled receptors in the pathology of Alzheimer's disease , 2011, Nature Reviews Neuroscience.
[11] Todd E. Golde,et al. Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift , 2011, Neuron.
[12] R. Tanzi,et al. The Genetics of Alzheimer Disease: Back to the Future , 2010, Neuron.
[13] C. Kruse,et al. Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease. , 2010, Brain : a journal of neurology.
[14] J. Wess,et al. The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner , 2010, Proceedings of the National Academy of Sciences.
[15] Gang Pei,et al. A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis , 2010, Cell Research.
[16] A. Fagan,et al. APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging , 2010, Annals of neurology.
[17] Jiuhong Kang,et al. Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance , 2009, Nature.
[18] B. De Strooper,et al. The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons , 2009, Science.
[19] Y. Ihara,et al. Aβ46 Is Processed to Aβ40 and Aβ43, but Not to Aβ42, in the Low Density Membrane Domains* , 2008, Journal of Biological Chemistry.
[20] R. Rodriguiz,et al. A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior , 2008, Cell.
[21] J. Trojanowski,et al. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.
[22] R. Eglen,et al. Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery. , 2007, Assay and drug development technologies.
[23] R. Lefkowitz,et al. β-Arrestins and Cell Signaling , 2007 .
[24] Yun Bai,et al. Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation , 2006, Nature Medicine.
[25] Hartwig Wolburg,et al. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology , 2006, EMBO reports.
[26] Olivier Lichtarge,et al. β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor* , 2006, Journal of Biological Chemistry.
[27] 角田 聡子. γ-secretase activity is present in rafts but is not cholesterol-dependent , 2006 .
[28] T. Sotnikova,et al. An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior , 2005, Cell.
[29] Haipeng Cheng,et al. Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains* , 2005, Journal of Biological Chemistry.
[30] H. Schiöth,et al. The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes , 2005, Molecular Pharmacology.
[31] S. Hébert,et al. Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity , 2004, Neurobiology of Disease.
[32] P. Wong,et al. Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes* , 2004, Journal of Biological Chemistry.
[33] B. de Strooper,et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway , 2004, The Journal of cell biology.
[34] L. Tarassishin,et al. Stereoselective Synthesis of Photoreactive Peptidomimetic γ-Secretase Inhibitors , 2004 .
[35] R. Lefkowitz,et al. Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor* , 2004, Journal of Biological Chemistry.
[36] M. Parenti,et al. G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there? , 2004, Journal of molecular endocrinology.
[37] D. Selkoe,et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. , 2004, Biochemistry.
[38] T. Gudermann,et al. Receptors and G proteins as primary components of transmembrane signal transduction , 1995, Journal of Molecular Medicine.
[39] H. Braak,et al. Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.
[40] L. Hunyady,et al. Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[41] L. Hunyady,et al. The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. , 2003, Endocrinology.
[42] B. Strooper,et al. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex , 2003, Neuron.
[43] M. Mortrud,et al. The G protein-coupled receptor repertoires of human and mouse , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[44] D. Selkoe,et al. Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[45] S. Younkin,et al. Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains , 2002, Neurobiology of Disease.
[46] B. Strooper,et al. Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins , 2001, Neuron.
[47] H. Cai,et al. BACE1 is the major β-secretase for generation of Aβ peptides by neurons , 2001, Nature Neuroscience.
[48] Larry L. Constantine,et al. Back to the future , 2001, CACM.
[49] Marc G. Caron,et al. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence , 2000, Nature.
[50] Graeme Irvine Stevenson,et al. L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity , 2000 .
[51] Min Xu,et al. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state , 2000, Neurobiology of Aging.
[52] William J. Ray,et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.
[53] Hugo Vanderstichele,et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein , 1998, Nature.
[54] J. Seidman,et al. β-Arrestin1 Knockout Mice Appear Normal but Demonstrate Altered Cardiac Responses to β-Adrenergic Stimulation , 1997 .
[55] M. Caron,et al. Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.
[56] H. Kowarzyk. Structure and Function. , 1910, Nature.