Desmopressin after cardiac surgery in bleeding patients. A multicenter randomized trial

Previous studies showed that desmopressin decreases post‐operative blood loss in patients undergoing cardiac surgery. These studies were small and never studied the effect of desmopressin in patients with active bleeding. Objective of the study was to determine whether desmopressin reduces red blood cells transfusion requirements in patients with active bleeding after cardiac surgery who had been pre‐treated with tranexamic acid.

[1]  M. Ranucci,et al.  Hemodilution on Cardiopulmonary Bypass as a Determinant of Early Postoperative Hyperlactatemia , 2015, PloS one.

[2]  O. Alfieri,et al.  Cardiac surgery in 260 octogenarians: a case series , 2015, BMC Anesthesiology.

[3]  J. Apfelbaum.  Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*. , 2015, Anesthesiology.

[4]  L. Alberio,et al.  The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects. , 2014, Blood.

[5]  S. Galvin,et al.  Desmopressin for reducing postoperative blood loss and transfusion requirements following cardiac surgery in adults. , 2014, Interactive cardiovascular and thoracic surgery.

[6]  P. Wouters,et al.  Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. , 2013, European journal of anaesthesiology.

[7]  T Greco,et al.  Review Article , 2022 .

[8]  Phil Edwards,et al.  Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis , 2012, BMJ : British Medical Journal.

[9]  F. Sellke,et al.  Safety and Efficacy of Recombinant Activated Factor VII: A Randomized Placebo-Controlled Trial in the Setting of Bleeding After Cardiac Surgery , 2009, Circulation.

[10]  G. Biondi-Zoccai,et al.  Desmopressin Reduces Transfusion Needs after Surgery: A Meta-analysis of Randomized Clinical Trials , 2008, Anesthesiology.

[11]  M. Ranucci,et al.  Surgical reexploration after cardiac operations: why a worse outcome? , 2008, The Annals of thoracic surgery.

[12]  M. Cattaneo.  The use of desmopressin in open‐heart surgery , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[13]  Liang Li,et al.  Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting* , 2006, Critical care medicine.

[14]  T. Mihaljevic,et al.  Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. , 2006, The Annals of thoracic surgery.

[15]  M. Karlsson,et al.  Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients. , 2004, British journal of clinical pharmacology.

[16]  S. Leal-Noval,et al.  Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. , 2001, Chest.

[17]  M. Goldman.  Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints , 2000 .

[18]  Mannucci.  Desmopressin (DDAVP) in the treatment of bleeding disorders: the first twenty years , 2000, Haemophilia : the official journal of the World Federation of Hemophilia.

[19]  E. Spitznagel,et al.  Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: a randomised controlled trial , 1999, The Lancet.

[20]  P. Mannucci,et al.  The Effect of Desmopressin on Reducing Blood Loss in Cardiac Surgery – A Meta-Analysis of Double-Blind, Placebo-Controlled Trials , 1995, Thrombosis and Haemostasis.

[21]  M. Moia,et al.  DDAVP shortens the prolonged bleeding times of patients with severe von Willebrand disease treated with cryoprecipitate. Evidence for a mechanism of action independent of released von Willebrand factor , 1989 .

[22]  R. Weintraub,et al.  Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial. , 1986, The New England journal of medicine.