Stroke Risk Factors

Abstract Despite advances in the treatment of acute cerebral infarction, the most effective method of reducing stroke morbidity and mortality is the identification and modification of stroke risk factors. Modifiable stroke risk factors include hypertension, atrial fibrillation, hypercholesterolemia, cigarette smoking, hyperhomocystinemia, and carotid stenosis. Improved identification of individuals at increased stroke risk due to these factors can reduce individual risk and the cost to society of the consequences of stroke.

[1]  N L Greengold,et al.  Prevention of a first stroke: a review of guidelines and a multidisciplinary consensus statement from the National Stroke Association. , 1999, JAMA.

[2]  D. Kromhout Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts , 1995, The Lancet.

[3]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[4]  E. Barrett-Connor Cigarette smoking as a risk factor in stroke. , 1988, JAMA.

[5]  P. Gorelick,et al.  Stroke Prevention: An Opportunity for Efficient Utilization of Health Care Resources During the Coming Decade , 1994, Stroke.

[6]  M. Hommel,et al.  Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. , 1994, The New England journal of medicine.

[7]  R B D'Agostino,et al.  Cigarette smoking as a risk factor for stroke. The Framingham Study. , 1988, JAMA.

[8]  R. Andersen,et al.  OBESITY AND ITS RELATIONSHIP TO MARITAL STATUS IN US ADULTS. RESULTS FROM THE THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY, 1988-1994 , 2001 .

[9]  R. Collins,et al.  Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. , 1994, British medical bulletin.

[10]  M. Eliasziw,et al.  The Dilemma of Surgical Treatment for Patients with Asymptomatic Carotid Disease , 1995, Annals of Internal Medicine.

[11]  W. Garraway,et al.  The changing pattern of hypertension and the declining incidence of stroke. , 1987, JAMA.

[12]  J. Broderick,et al.  The Greater Cincinnati/Northern Kentucky Stroke Study: preliminary first-ever and total incidence rates of stroke among blacks. , 1998, Stroke.

[13]  R. D'Agostino,et al.  Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis. , 1997, The New England journal of medicine.

[14]  Identification of patent foramen ovale permitting paradoxic embolism. , 1996, Journal of the American College of Cardiology.

[15]  D. Weiss,et al.  Cardiac Prognosis of Patients With Carotid Stenosis and No History of Coronary Artery Disease , 1994, Stroke.

[16]  M. Paracchini,et al.  High prevalence of antiphosphatidylinositol antibodies in young patients with cerebral ischemia of undetermined cause. , 1998, Stroke.

[17]  D. Sackett,et al.  Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. , 1991, The New England journal of medicine.

[18]  C. Camargo,et al.  Moderate alcohol consumption and stroke. The epidemiologic evidence. , 1989, Stroke.

[19]  B. Lindegård,et al.  Associations between brain infarction, diabetes and alcoholism: observations from the Gothenburg population cohort study , 1987, Acta neurologica Scandinavica.

[20]  I. Rosenwaike Mortality among the Puerto Rican born in New York City. , 1983, Social science quarterly.

[21]  W. Daniel,et al.  Identification of patent foramen ovale permitting paradoxic embolism. , 1995, Journal of the American College of Cardiology.

[22]  J. Kistler,et al.  Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. , 1995, The New England journal of medicine.

[23]  R. Collins,et al.  Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. , 1998, The New England journal of medicine.

[24]  B Rosner,et al.  Smoking cessation and decreased risk of stroke in women. , 1993, JAMA.

[25]  J. Weinberger,et al.  Elevated anticardiolipin antibody titer is a stroke risk factor in a multiethnic population independent of isotype or degree of positivity. , 1999, Stroke.

[26]  P. Wolf,et al.  Manifestations of coronary disease predisposing to stroke. The Framingham study. , 1983, JAMA.

[27]  S. Tuhrim,et al.  Aortic plaque in patients with brain ischemia , 1992, Neurology.

[28]  D. Jacobs,et al.  Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. , 1989, The New England journal of medicine.

[29]  P. Wolf,et al.  Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study. , 1970, JAMA.

[30]  P. Sorlie,et al.  Ethnic Differences in Stroke Mortality Between Non‐Hispanic Whites, Hispanic Whites, and Blacks: The National Longitudinal Mortality Study , 1994, Stroke.

[31]  P. Wolf,et al.  Characteristics and prognosis of lone atrial fibrillation. 30-year follow-up in the Framingham Study. , 1985, JAMA.

[32]  F. Buonanno,et al.  Lack of evidence of an association between mitral-valve prolapse and stroke in young patients. , 1999, The New England journal of medicine.

[33]  K. Beach,et al.  The natural history of carotid arterial disease in asymptomatic patients with cervical bruits. , 1984, Stroke.

[34]  J. Rand Antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms. , 1998, The American journal of the medical sciences.

[35]  D. Reed,et al.  Diabetes and the risk of stroke. The Honolulu Heart Program. , 1987, JAMA.

[36]  W M O'Fallon,et al.  Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989. , 1996, Stroke.

[37]  J. Roberts,et al.  Valvular strands and cerebral ischemia. Effect of demographics and strand characteristics. , 1997, Stroke.

[38]  R. Sherwin,et al.  Determinants of black-white differences in the risk of cerebral infarction. The National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. , 1995, Archives of internal medicine.

[39]  S. Tuhrim,et al.  Antiphosphatidyl serine antibodies are independently associated with ischemic stroke. , 1999, Neurology.

[40]  R. Kronmal,et al.  The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.

[41]  C. Furberg Natural statins and stroke risk. , 1999, Circulation.

[42]  G. Lamas,et al.  Ventricular dysfunction and the risk of stroke after myocardial infarction. , 1997, The New England journal of medicine.

[43]  H. Meldrum,et al.  Appropriate Use of Carotid Endarterectomy , 2000, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[44]  R. Gillum Stroke in blacks. , 1988, Stroke.

[45]  ThomasBrott,et al.  The Greater Cincinnati/Northern Kentucky Stroke Study , 1998 .

[46]  J. Staessen,et al.  Treatment of isolated systolic hypertension in the elderly: the Syst-Eur trial. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. , 1999, Clinical and experimental hypertension.

[47]  Ames,et al.  Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. , 1999, The New England journal of medicine.

[48]  R B D'Agostino,et al.  Probability of stroke: a risk profile from the Framingham Study. , 1991, Stroke.

[49]  T. Wilt,et al.  Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. , 1999, The New England journal of medicine.

[50]  K. Lees,et al.  Anticardiolipin antibodies in an unselected stroke population , 1994, The Lancet.

[51]  R. Sacco,et al.  The protective effect of moderate alcohol consumption on ischemic stroke. , 1999, JAMA.

[52]  R. Brey Anticardiolipin antibodies are an independent risk factor for first ischemic stroke , 1993, Neurology.

[53]  C. Warlow,et al.  MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis , 1991, The Lancet.

[54]  C. Hennekens,et al.  Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials. , 1997, JAMA.

[55]  P. Wolf,et al.  Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. , 1991, Stroke.

[56]  Philip D. Harvey,et al.  Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38 , 1998, BMJ.

[57]  R. D'Agostino,et al.  Secular Trends in Stroke Incidence and Mortality: The Framingham Study , 1992, Stroke.

[58]  Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. , 1991, JAMA.

[59]  S. Kittner,et al.  Total homocyst(e)ine concentration and the likelihood of nonfatal stroke: results from the Third National Health and Nutrition Examination Survey, 1988-1994. , 1998, Stroke.

[60]  S. Ebrahim,et al.  Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men , 1995, The Lancet.

[61]  D Kromhout,et al.  Twenty-five-year prediction of stroke deaths in the seven countries study: the role of blood pressure and its changes. , 1996, Stroke.

[62]  R. Sacco,et al.  Patent Foramen Ovale as a Risk Factor for Cryptogenic Stroke , 1992, Annals of Internal Medicine.

[63]  M. Hennerici,et al.  The Feasibility of a Collaborative Double-Blind Study Using an Anticoagulant , 1997 .

[64]  F. Weilert,et al.  Therapies for ulcers associated with nonsteroidal antiinflammatory drugs. , 1998, The New England journal of medicine.

[65]  C. Duyckaerts,et al.  The prevalence of ulcerated plaques in the aortic arch in patients with stroke. , 1992, The New England journal of medicine.

[66]  R. Sacco,et al.  Stroke incidence among white, black, and Hispanic residents of an urban community: the Northern Manhattan Stroke Study. , 1998, American journal of epidemiology.

[67]  M. Chassin,et al.  Appropriate use of carotid endarterectomy. , 1998, The New England journal of medicine.

[68]  S. Tuhrim,et al.  Transesophageal echocardiography: diagnostic and clinical applications in the evaluation of the stroke patient. , 1997, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[69]  M. Stampfer,et al.  Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis , 1992, Annals of Internal Medicine.