Roles of Stearoyl-CoA Desaturase-1 in Hepatocellular Carcinoma

The endoplasmic reticulum (ER) is a very important organelle in the eukaryotic cells. It has two types: rough endoplasmic reticulum (rough ER, RER) and smooth endoplasmic reticulum (smooth ER, SER). ER plays a vital role in many cellular processes such as secretory and membrane protein synthesis, folding, assembly, trafficking and post-modulation.

[1]  M. Simon,et al.  Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. , 2014, Trends in cell biology.

[2]  R. Mancini,et al.  Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells , 2013, Cell Death and Disease.

[3]  D. Calvisi,et al.  SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice , 2013, PloS one.

[4]  L. Beretta,et al.  Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. , 2013, Cancer research.

[5]  Juan Chen,et al.  Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells , 2013, Molecular and Cellular Biochemistry.

[6]  X. Wang,et al.  Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes. , 2013, Gastroenterology.

[7]  J. Copland,et al.  Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma , 2013, Clinical Cancer Research.

[8]  R. A. Igal Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. , 2010, Carcinogenesis.

[9]  C. Casiano,et al.  Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity , 2010, Brain Research.

[10]  R. A. Igal,et al.  Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts. , 2009, Life sciences.

[11]  J. Menéndez,et al.  Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.

[12]  F. Foufelle,et al.  SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective , 2007, Hormone Research in Paediatrics.

[13]  C. Thompson,et al.  Akt-dependent transformation: there is more to growth than just surviving , 2005, Oncogene.

[14]  M. Miyazaki,et al.  Regulation of stearoyl-CoA desaturase expression , 2004, Lipids.

[15]  M. Gariboldi,et al.  Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. , 2002, Carcinogenesis.

[16]  J. Ntambi Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. , 1999, Journal of lipid research.

[17]  J. Fung,et al.  Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma. , 2014, The Journal of surgical research.

[18]  Funda Meric-Bernstam,et al.  High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients , 2012, Breast Cancer Research and Treatment.