Phylogeny and Evolution

Beginning in the late 1970s, results from a variety of studies enabled an increasingly detailed Mollicutes phylogenetic tree to be reconstructed4. The overall tree is based on 16S rRNA sequence analyses and provides a framework for results on other relationships between Mollicutes strains and between Mollicutes and Gram-positive bacteria; e.g., other macromolecule sequences, lipid composition, metabolic enzymes and pathways, gene organization, and antibiotic sensitivity.

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