Nanolayer multi-agent scaled delivery from implant surface

One of the important problems in the field of orthopedic medicine is the ability to create a stable bone-materials interface with an implant while fighting against bacterial infection. The most effective treatment requires the delivery of exacting amounts of therapeutics of different types over appropriate timeframes in and around the implant, while maintaining mechanical integrity of the implant materials and allowing for bone integration on their surfaces. Traditional bulk polymer systems such as bone cement, however, cannot load sufficient amounts of therapeutic to eradicate existing infection, are insufficient or infeasible for the release of sensitive biologic drugs that considerably aid in bone regeneration, and lead to substandard mechanical properties and retarded bone repair.

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