Phase Transfer–Catalyzed, One-Pot Synthesis of Some Novel N-Pyrimidinyl-N′-nicotinyl Thiourea Derivatives

Abstract A new series of acyl thiourea derivatives were synthesized in one-pot using PEG-600 as the phase transfer catalyst (PTC). The structures of title compounds were characterized by 1H NMR, IR, MS, and elemental analysis. In addition, the fungicidal activity of the acyl thiourea derivatives were tested, which showed that most of them exhibit moderate activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT

[1]  Zhengming Li,et al.  Synthesis and Antifungal Activities of New Pyrazole Derivatives via 1,3‐dipolar Cycloaddition Reaction , 2010, Chemical biology & drug design.

[2]  Zhengming Li,et al.  Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication. , 2010, European journal of medicinal chemistry.

[3]  Zhengming Li,et al.  Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides. , 2009, European journal of medicinal chemistry.

[4]  Zhengming Li,et al.  Synthesis, Herbicidal Activities and Comparative Molecular Field Analysis Study of Some Novel Triazolinone Derivatives , 2009, Chemical biology & drug design.

[5]  Jinhuai Liu,et al.  Highly Sensitive Thin Film Sensor Based on Worm‐like Carbon Nanofibers for Detection of Ammonia in Workplace , 2008 .

[6]  Y. Xiaodong.  PHASE TRANSFER CATALYSTS PROMOTING THE ONE-POT SYNTHESIS UNDER ULTRASONIC IRRADIATION AND BIOLOGICAL ACTIVITY OF N-(5-SUBSTITUTED-1,3,4-THIADIAZOLE-2-YL)-N'-(5-METHYLISOXAZOYL)-THIOUREA DERIVATIVES , 2007 .

[7]  K. Asai,et al.  Arterial baroreflex sensitivity is a good predictor of inotropic responses to a phosphodiesterase inhibitor in human heart failure , 2006, Clinical cardiology.

[8]  You‐Ming Zhang,et al.  Microwave Promoted Efficient Synthesis of N‐Aryl‐N′‐aroyl Thioureas Under Solvent‐Free and Phase Transfer Catalysis Conditions , 2004 .

[9]  L. Duan,et al.  Ultrasonic Irradiated Synthesis of N-(5-aryl-2-furoyl)thiourea Derivatives Containing Substituted Pyrimidine Ring under Phase Transfer Catalysis , 2004 .

[10]  You‐Ming Zhang,et al.  PHASE TRANSFER CATALYZED SYNTHESIS OF THIOSEMICARBAZIDE AND bis-THIOSEMICARBAZIDE DERIVATIVES OF 2-ETHOXYBENZOIC ACID , 2004 .

[11]  P. Hodge,et al.  Polymer-Supported Reagents: The Use of Polymer-Supported Cyanide and Thiocyanate to Prepare Nitriles, Thiocyanates, and lsothiocyanates , 1980 .