Imaging inflammation: Direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy

To determine if the architectural features revealed by magnetic resonance microscopy (MRM) allow one to detect microscopic abnormalities associated with neuroinflammation in fixed brain sections from animals with experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS).

[1]  L W Hedlund,et al.  Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Function a , b , 1997, Annals of the New York Academy of Sciences.

[2]  Robbie Robertson,et al.  Comparison of the timing of acute blood‐brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis , 2001, The Journal of comparative neurology.

[3]  B. Trapp,et al.  Pathogenesis of tissue injury in MS lesions , 1999, Journal of Neuroimmunology.

[4]  J. Caillé,et al.  Early structural changes in acute MS lesions assessed by serial magnetization transfer studies , 1998, Neurology.

[5]  H P Hartung,et al.  In vivo MRI and its histological correlates in acute adoptive transfer experimental allergic encephalomyelitis. Quantification of inflammation and oedema. , 1996, Brain : a journal of neurology.

[6]  M. Rovaris,et al.  Contrast enhancement and the acute lesion in multiple sclerosis. , 2000, Neuroimaging clinics of North America.

[7]  P. Carnegie,et al.  Experimental autoimmune encephalomyelitis An anatomically-based explanation of clinical progression in rodents , 1982, Journal of Neuroimmunology.

[8]  B K Rutt,et al.  Magnetization transfer and multicomponent T2 relaxation measurements with histopathologic correlation in an experimental model of MS , 2000, Journal of magnetic resonance imaging : JMRI.

[9]  L W Hedlund,et al.  In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine. , 1999, Regional anesthesia and pain medicine.

[10]  G A Johnson,et al.  Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[11]  H. Koprowski,et al.  Ultrastructural studies of perivascular cuffing cells in multiple sclerosis brain. , 1975, The American journal of pathology.

[12]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.

[13]  A. MacKay,et al.  In vivo visualization of myelin water in brain by magnetic resonance , 1994, Magnetic resonance in medicine.

[14]  L W Hedlund,et al.  Magnetic Resonance Microscopy-A New Tool for the Toxicologic Pathologist , 1996, Toxicologic pathology.

[15]  R S Balaban,et al.  Challenges in small animal noninvasive imaging. , 2001, ILAR journal.

[16]  G A Johnson,et al.  A high‐temperature superconducting Helmholtz probe for microscopy at 9.4 T , 1999, Magnetic resonance in medicine.

[17]  M Rovaris,et al.  MRI correlates of cognitive dysfunction in multiple sclerosis patients. , 2000, Journal of neurovirology.

[18]  D. Laidlaw,et al.  MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis , 1998, Magnetic resonance in medicine.

[19]  M. Filippi,et al.  Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis: triple vs. single dose. , 2000, Magnetic resonance imaging.

[20]  G. Johnson,et al.  Magnetic Resonance Microscopy of the C57BL Mouse Brain , 2000, NeuroImage.

[21]  W. Brück,et al.  Macrophages in multiple sclerosis. , 1996, Immunobiology.

[22]  M. Rovaris,et al.  MRI evolution of new MS lesions enhancing after different doses of gadolinium , 1998, Acta neurologica Scandinavica.

[23]  R. Balaban,et al.  Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo , 1989, Magnetic resonance in medicine.

[24]  Frederik Barkhof,et al.  MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS) , 1999, Multiple sclerosis.

[25]  R. Poston,et al.  Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis , 1989, Journal of the Neurological Sciences.

[26]  B. Rutt,et al.  In vivo measurements of multi-component T2 relaxation behaviour in guinea pig brain. , 1999, Magnetic resonance imaging.

[27]  L W Hedlund,et al.  Histology by magnetic resonance microscopy. , 1993, Magnetic resonance quarterly.

[28]  G. Johnson,et al.  3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy. , 1999, Neuroreport.

[29]  E. Staab,et al.  Preautopsy magnetic resonance imaging: initial experience. , 1990, Magnetic resonance imaging.

[30]  P. Matthews,et al.  Putting Magnetic Resonance Spectroscopy Studies in Context: Axonal Damage and Disability in Multiple Sclerosis , 1998, Seminars in neurology.