Network in Common Lymphoid Progenitors Establishment of a Transcription Factor EBF 1 Is Essential for B-Lineage Priming and Zetterblad

Zetterblad, David Bryder and Mikael SigvardssonSasan Zandi, Robert Mansson, Panagiotis Tsapogas, Jennyhttp://www.jimmunol.org/content/181/5/3364J Immunol€2008; 181:3364-3372; ;Referenceshttp://www.jimmunol.org/content/181/5/3364.full#ref-list-1This article cites 52 articles, 23 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  M. Sigvardsson,et al.  Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. , 2005, Blood.

[2]  M. Kondo,et al.  IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF , 2005, The Journal of experimental medicine.

[3]  M. Sigvardsson Overlapping Expression of Early B-Cell Factor and Basic Helix-Loop-Helix Proteins as a Mechanism To Dictate B-Lineage-Specific Activity of the λ5 Promoter , 2000, Molecular and Cellular Biology.

[4]  R. Grosschedl,et al.  Failure of B-cell differentiation in mice lacking the transcription factor EBF , 1995, Nature.

[5]  B. Kee,et al.  Early B Cell Factor Promotes B Lymphopoiesis with Reduced Interleukin 7 Responsiveness in the Absence of E2A , 2004, The Journal of experimental medicine.

[6]  M. Sigvardsson,et al.  Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development. , 1999, Journal of immunology.

[7]  S. Shinton,et al.  Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription , 2004, Nature Immunology.

[8]  Yonghong Xiao,et al.  FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis , 2007, Cell.

[9]  C. Cotta,et al.  Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage , 2003, The EMBO journal.

[10]  Shiaoching Gong,et al.  The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes , 1996, Nature.

[11]  K. Schubart,et al.  The OBF‐1 gene locus confers B cell‐specific transcription by restricting the ubiquitous activity of its promoter , 2003, European journal of immunology.

[12]  Y. Zhuang,et al.  Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA , 1998, Molecular and Cellular Biology.

[13]  M. Busslinger,et al.  Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors , 2007, Nature.

[14]  M. Sigvardsson,et al.  EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. , 1997, Immunity.

[15]  M. Busslinger,et al.  Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5 , 2006, Molecular and Cellular Biology.

[16]  Harinder Singh,et al.  Assembling a gene regulatory network for specification of the B cell fate. , 2004, Developmental cell.

[17]  R. Roeder,et al.  Functional Analysis of the OCA-B Promoter1 , 2000, The Journal of Immunology.

[18]  R. Grosschedl,et al.  Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. , 1999, Immunity.

[19]  E. Wagner,et al.  Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5 BSAP , 1994, Cell.

[20]  R. Hardy,et al.  Identification of the earliest B lineage stage in mouse bone marrow. , 1996, Immunity.

[21]  Rudolf Grosschedl,et al.  EBF2 regulates osteoblast-dependent differentiation of osteoclasts. , 2005, Developmental cell.

[22]  I. Weissman,et al.  Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow , 1997, Cell.

[23]  Lina A. Thoren,et al.  Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential A Revised Road Map for Adult Blood Lineage Commitment , 2005, Cell.

[24]  M. Busslinger,et al.  Essential functions of Pax-5 (BSAP) in pro-B cell development. , 1997, Immunobiology.

[25]  A. M. Morrison,et al.  Identification of BSAP (Pax‐5) target genes in early B‐cell development by loss‐ and gain‐of‐function experiments , 1998, The EMBO journal.

[26]  H. Igarashi,et al.  Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. , 2002, Immunity.

[27]  J. Nardone,et al.  Foxp1 is an essential transcriptional regulator of B cell development , 2006, Nature Immunology.

[28]  S. Bilke,et al.  Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific mb-1 Promoter , 2002, Molecular and Cellular Biology.

[29]  C. Turck,et al.  Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. , 1993, Genes & development.

[30]  Alexei A. Sharov,et al.  Gene expression A web-based tool for principal component and significance analysis of microarray data , 2005 .

[31]  M. Schlissel,et al.  A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. , 2003, Immunity.

[32]  W. Schaffner,et al.  B lymphocytes are impaired in mice lacking the transcriptional co‐activator Bob1/OCA‐B/OBF1 , 1996, European journal of immunology.

[33]  R. Månsson,et al.  The Cxcl12, Periostin, and Ccl9 Genes Are Direct Targets for Early B-cell Factor in OP-9 Stroma Cells* , 2007, Journal of Biological Chemistry.

[34]  M. Greaves,et al.  Multilineage gene expression precedes commitment in the hemopoietic system. , 1997, Genes & development.

[35]  K. Anderson,et al.  B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells. , 2008, Blood.

[36]  M. Sigvardsson,et al.  The B29 (Immunoglobulin β-Chain) Gene Is a Genetic Target for Early B-Cell Factor , 1999, Molecular and Cellular Biology.

[37]  Shamit Soneji,et al.  Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. , 2007, Immunity.

[38]  H. Weintraub,et al.  The helix-loop-helix gene E2A is required for B cell formation , 1994, Cell.

[39]  E. Bertolino,et al.  Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 , 2008, Nature Immunology.

[40]  R. Månsson,et al.  Pearson Correlation Analysis of Microarray Data Allows for the Identification of Genetic Targets for Early B-cell Factor*[boxs] , 2004, Journal of Biological Chemistry.

[41]  M. Schebesta,et al.  Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. , 2002, Immunity.

[42]  M. Busslinger,et al.  Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. , 2007, Immunity.

[43]  A. Cumano,et al.  Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors , 2005, The Journal of experimental medicine.

[44]  T. Gaasterland,et al.  Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Yan Zhou,et al.  Lineage specification and plasticity in CD19− early B cell precursors , 2006, The Journal of experimental medicine.

[46]  W. Schaffner,et al.  Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. , 1989, Nucleic acids research.

[47]  T. Wirth,et al.  B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice , 2003, The Journal of experimental medicine.

[48]  A. Rolink,et al.  B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation , 1996, Nature.

[49]  R. Gerstein,et al.  E47 is required for V(D)J recombinase activity in common lymphoid progenitors , 2005, The Journal of experimental medicine.

[50]  P. Matthias,et al.  The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. , 2006, Proceedings of the National Academy of Sciences of the United States of America.