Effect of Cobalt Precursors on Cobalt-Hydroxyapatite Used in Bone Regeneration and MRI

In clinical dentistry practice, supplemental bone surgery or jawbone defect after tooth extraction must be assisted by a bone-filling material. Cobalt-substituted hydroxyapatite (COHA) effectively promotes bone cell growth, reduces the inflammatory response, and is an antibacterial agent. COHA can therefore be used as an alveolar bone-filling material or guided bone regeneration membrane. Meanwhile, COHA can be used in magnetic resonance imaging (MRI) with negative contrast agents and targeting materials without causing metal interference with the image. Hence, COHA has received increasing amounts of attention in recent years. However, the influence of different cobalt precursors on the synthesized COHA is still unknown. Therefore, COHA synthesized from 3 cobalt precursors (cobalt chloride, cobalt nitrate, and cobalt sulfate) was compared in this study. The results show that COHA synthesized by the precursor with the smallest anion radius, cobalt chloride, has a larger particle size (239 nm) and a higher cobalt ion substitution rate (15.6%). When the cobalt ion substitution rate increases, the MRI has a stronger contrast. Bioactivity data indicate that COHAC is more susceptible to degradation and therefore releases more cobalt ions to contribute to the differentiation of bone cells. Based on these studies, COHAC prepared with the cobalt chloride precursor has a higher cobalt ion substitution rate, faster degradation rate, better image contrast, and better bioactivity. It is therefore the preferred choice of bone-filling material for alveolar bone regeneration.

[1]  Yi Deng,et al.  Dual therapeutic cobalt-incorporated bioceramics accelerate bone tissue regeneration. , 2019, Materials science & engineering. C, Materials for biological applications.

[2]  Ting-Yun Huang,et al.  Long-term in vitro degradation behavior and biocompatibility of polycaprolactone/cobalt-substituted hydroxyapatite composite for bone tissue engineering. , 2019, Dental materials : official publication of the Academy of Dental Materials.

[3]  Wei-Chun Lin,et al.  The Effect of Electrode Topography on the Magnetic Properties and MRI Application of Electrochemically-Deposited, Synthesized, Cobalt-Substituted Hydroxyapatite , 2019, Nanomaterials.

[4]  Wei-Chun Lin,et al.  A Comparative Study on the Direct and Pulsed Current Electrodeposition of Cobalt-Substituted Hydroxyapatite for Magnetic Resonance Imaging Application , 2018, Materials.

[5]  E. Kurek,et al.  Effect of carbonate substitution on physicochemical and biological properties of silver containing hydroxyapatites. , 2017, Materials science & engineering. C, Materials for biological applications.

[6]  Lingzhou Zhao,et al.  Hypoxia-mimicking Co doped TiO2 microporous coating on titanium with enhanced angiogenic and osteogenic activities. , 2016, Acta biomaterialia.

[7]  Li Li,et al.  In vitro study on the degradation of lithium-doped hydroxyapatite for bone tissue engineering scaffold. , 2016, Materials science & engineering. C, Materials for biological applications.

[8]  C. V. van Blitterswijk,et al.  Stimulatory effect of cobalt ions incorporated into calcium phosphate coatings on neovascularization in an in vivo intramuscular model in goats. , 2016, Acta biomaterialia.

[9]  Min Qi,et al.  Development of multifunctional cobalt ferrite/graphene oxide nanocomposites for magnetic resonance imaging and controlled drug delivery , 2016 .

[10]  M. Ferraris,et al.  Synthesis of magnetic hydroxyapatite by hydrothermal–microwave technique: Dielectric, protein adsorption, blood compatibility and drug release studies , 2015 .

[11]  D. Uskoković,et al.  Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite , 2015 .

[12]  Chengtie Wu,et al.  The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate. , 2015, Biomaterials.

[13]  S. Hsu,et al.  Poly(vinyl alcohol) Nanocomposites Reinforced with Bamboo Charcoal Nanoparticles: Mineralization Behavior and Characterization , 2015, Materials.

[14]  S. Sumathi,et al.  In vitro degradation of multisubstituted hydroxyapatite and fluorapatite in the physiological condition , 2015 .

[15]  Gavin Jell,et al.  Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair. , 2015, Biomaterials.

[16]  M. Marinović‐Cincović,et al.  Synthesis, structural characterisation and antibacterial activity of Ag+-doped fluorapatite nanomaterials prepared by neutralization method , 2015 .

[17]  M. Ürgen,et al.  Carbonated hydroxyapatite deposition at physiological temperature on ordered titanium oxide nanotubes using pulsed electrochemistry , 2014 .

[18]  M. Wei,et al.  Synthesis and characterization of cobalt-substituted hydroxyapatite powders , 2014 .

[19]  I. Martin,et al.  Reconstruction of Extensive Long-Bone Defects in Sheep Using Porous Hydroxyapatite Sponges , 2014, Calcified Tissue International.

[20]  M. Gelinsky,et al.  Chemical characterization of hydroxyapatite obtained by wet chemistry in the presence of V, Co, and Cu ions. , 2013, Materials science & engineering. C, Materials for biological applications.

[21]  D. Uskoković,et al.  Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones , 2012, Journal of Materials Science: Materials in Medicine.

[22]  Wei Fan,et al.  Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. , 2012, Biomaterials.

[23]  Hong Yang,et al.  Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery. , 2011, Acta biomaterialia.

[24]  P. Ma,et al.  Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography , 2010, Advanced functional materials.

[25]  Wei Fan,et al.  Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model. , 2010, Biomaterials.

[26]  D. Chappard,et al.  Cobalt, chromium and nickel affect hydroxyapatite crystal growth in vitro. , 2010, Acta biomaterialia.

[27]  Thomas Meade,et al.  Effects of shape and size of cobalt ferrite nanostructures on their MRI contrast and thermal activation. , 2009, The journal of physical chemistry. C, Nanomaterials and interfaces.

[28]  J. Dobson,et al.  Development of Superparamagnetic Iron Oxide Nanoparticles (SPIONS) for Translation to Clinical Applications , 2008, IEEE Transactions on NanoBioscience.

[29]  B. Kimia,et al.  Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI. , 2008, Osteoarthritis and cartilage.

[30]  S. Hsu,et al.  Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response. , 2008, Biomacromolecules.

[31]  A. Boccaccini,et al.  Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. , 2006, Biomaterials.