Survival outcomes after synchronous para‐aortic lymph node metastasis in colorectal cancer: A systematic review

Synchronous para‐aortic lymph node metastasis (PALNM) in colorectal cancer (CRC) is a relatively rare clinical entity. There is a lack of consensus on management of these patients, and the role of para‐aortic lymph node dissection (PALND) remains controversial. This systematic review aims to describe the survival outcomes in colorectal cancer with synchronous PALNM when lymph node dissection is performed.

[1]  Song-yan Li,et al.  Effect of radical lymphadenectomy in colorectal cancer with para-aortic lymph node metastasis: a systematic review and meta-analysis , 2022, BMC Surgery.

[2]  Ying Huang,et al.  Para‐aortic lymph node dissection in left‐sided colorectal cancer: Risk factors, prognostic impact, and therapeutic value , 2022, Journal of surgical oncology.

[3]  S. Ascani,et al.  Long-Term Outcomes of Surgical Resection of Pathologically Confirmed Isolated Para-Aortic Lymph Node Metastases in Colorectal Cancer: A Systematic Review , 2022, Cancers.

[4]  S. Ishihara,et al.  Predictive factors of survival of colorectal cancer patients after para-aortic lymph node metastasis , 2021, International Journal of Clinical Oncology.

[5]  Atsuko Okamoto,et al.  New Technique of Laparoscopic Paraaortic Lymph Node Dissection for Colorectal Cancer Using Fluorescence Navigation. , 2021, Cancer diagnosis & prognosis.

[6]  J. Huh,et al.  Effect of lymphadenectomy in colorectal cancer with isolated synchronous para‐aortic lymph node metastasis , 2021, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[7]  D. Schrag,et al.  Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. , 2021, JAMA.

[8]  M. Hübner,et al.  Site of Recurrence and Survival after Surgery for Colorectal Peritoneal Metastasis. , 2021, Journal of the National Cancer Institute.

[9]  Anas M. Saad,et al.  Colorectal Cancer Epidemiology: Recent trends and Impact on Outcomes. , 2020, Current drug targets.

[10]  E. Aly,et al.  Lateral pelvic lymph node dissection in the management of locally advanced low rectal cancer: Summary of the current evidence. , 2020, Surgical oncology.

[11]  Tomohiro Yamaguchi,et al.  Diagnostic value of computed tomography (CT) and positron emission tomography (PET) for paraaortic lymph node metastasis from left-sided colon and rectal cancer. , 2020, Asian journal of surgery.

[12]  Kazuyoshi Yamamoto,et al.  The treatment strategy of R0 resection in colorectal cancer with synchronous para-aortic lymph node metastasis , 2020, World Journal of Surgical Oncology.

[13]  J. Sakamoto,et al.  Oncologic outcomes after resection of para-aortic lymph node metastasis in left-sided colon and rectal cancer , 2020, PloS one.

[14]  G. Choi,et al.  Clinical Implications of Lymph Node Metastasis in Colorectal Cancer: Current Status and Future Perspectives , 2019, Annals of coloproctology.

[15]  I. Endo,et al.  Long-term outcome and prognostic factors for patients with para-aortic lymph node dissection in left-sided colorectal cancer , 2019, International Journal of Colorectal Disease.

[16]  Y. Kanemitsu,et al.  Improving Selection for Resection of Synchronous Para-Aortic Lymph Node Metastases in Colorectal Cancer , 2018, Digestive Surgery.

[17]  J. Engstrand,et al.  Colorectal cancer liver metastases – a population-based study on incidence, management and survival , 2018, BMC Cancer.

[18]  K. Hata,et al.  Comparison of the guidelines for colorectal cancer in Japan, the USA and Europe , 2017, Annals of gastroenterological surgery.

[19]  C. Schmidt,et al.  Surgical Treatment of Metastatic Colorectal Cancer. , 2017, Surgical oncology clinics of North America.

[20]  J. Kim,et al.  Oncologic significance of para-aortic lymph node and inferior mesenteric lymph node metastasis in sigmoid and rectal adenocarcinoma. , 2017, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[21]  N. Kim,et al.  Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer? , 2017, Cancer research and treatment : official journal of Korean Cancer Association.

[22]  S. Nagayama,et al.  The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis. , 2017, Asian journal of surgery.

[23]  Tomohiro Yamaguchi,et al.  Long-term outcomes after resection of para-aortic lymph node metastasis from left-sided colon and rectal cancer , 2017, International Journal of Colorectal Disease.

[24]  G. Tan,et al.  Management of para-aortic lymph node metastasis in colorectal patients: A systemic review. , 2016, Surgical oncology.

[25]  Jan Sundquist,et al.  Patterns of metastasis in colon and rectal cancer , 2016, Scientific Reports.

[26]  N. Kim,et al.  Surgical management of extra-regional lymph node metastasis in colorectal cancer , 2016, Expert review of anticancer therapy.

[27]  G. Choi,et al.  Laparoscopic para-aortic lymph node dissection for patients with primary colorectal cancer and clinically suspected para-aortic lymph nodes , 2015, Annals of surgical treatment and research.

[28]  E. D. de Vries,et al.  Rectal and colon cancer: Not just a different anatomic site. , 2015, Cancer treatment reviews.

[29]  N. Haboubi,et al.  The Miles operation – extralevator abdominoperineal excision , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[30]  Bin Wu,et al.  Differences in gene expression profiles and carcinogenesis pathways between colon and rectal cancer , 2012, Journal of digestive diseases.

[31]  J. Lim,et al.  Extended Lymph Node Dissection for Rectal Cancer with Radiologically Diagnosed Extramesenteric Lymph Node Metastasis , 2009, Annals of Surgical Oncology.

[32]  P. Radice,et al.  Different Genetic Features Associated with Colon and Rectal Carcinogenesis , 2004, Clinical Cancer Research.

[33]  M. Stearns,et al.  Five-year results of abdominopelvic lymph node dissection for carcinoma of the rectum , 1959, Diseases of the colon and rectum.

[34]  Charles J. Kahi,et al.  Strategies for Colorectal Cancer Screening. , 2019, Gastroenterology.

[35]  S. Natsugoe Lymph Node Metastasis in Gastrointestinal Cancer , 2019, Springer Singapore.

[36]  Frcs D. C. Winter MD,et al.  Multivisceral Resection in Colorectal Cancer: A Systematic Review , 2013, Annals of Surgical Oncology.

[37]  R. Parks,et al.  Surgery for Colorectal Liver Metastases , 2013, Digestive Surgery.

[38]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[39]  J. Hardcastle,et al.  Colorectal cancer , 1993, Europe Against Cancer European Commission Series for General Practitioners.