Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis).

The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests.

[1]  M. Loeffelholz,et al.  The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  E. Theel,et al.  Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964–2017 , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  Y. Fakile,et al.  Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  J. Klausner,et al.  Clinical Test Performance of a Rapid Point-of-Care Syphilis Treponemal Antibody Test: A Systematic Review and Meta-analysis , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  K. Ghanem,et al.  Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  S. Lukehart,et al.  Biomedical Research Priorities for Modern Syphilis Clinical Management, Diagnosis, and Vaccines: Overview and Commentary for Unit 1 , 2018, Sexually transmitted diseases.

[7]  S. Norris,et al.  Long-Term In Vitro Culture of the Syphilis Spirochete Treponema pallidum subsp. pallidum , 2018, mBio.

[8]  K. Workowski,et al.  Sexually transmitted diseases treatment guidelines, 2015. , 2015, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[9]  J. Papp,et al.  Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014. , 2014, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[10]  QuickStats,et al.  Discordant results from reverse sequence syphilis screening--five laboratories, United States, 2006-2010. , 2011, MMWR. Morbidity and mortality weekly report.

[11]  Syphilis testing algorithms using treponemal tests for initial screening--four laboratories, New York City, 2005-2006. , 2008, MMWR. Morbidity and mortality weekly report.

[12]  G. Burstein,et al.  Sexually transmitted diseases treatment guidelines , 2003, Current opinion in pediatrics.

[13]  G. Pugliese,et al.  Severe Streptococcus pyogenes Infections, United Kingdom, 2003–2004 , 2008, Emerging infectious diseases.