Protein misfolding in the endoplasmic reticulum as a conduit to human disease
暂无分享,去创建一个
[1] P. Fischer,et al. Mutations in a translation initiation factor identify the target of a memory-enhancing compound , 2015, Science.
[2] Takashi Uehara,et al. S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration , 2006, Nature.
[3] K. Krnjević,et al. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α , 2014, Nature Neuroscience.
[4] Randal J. Kaufman,et al. From endoplasmic-reticulum stress to the inflammatory response , 2008, Nature.
[5] Xiaozhong Wang,et al. Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase , 1996, Science.
[6] A. Sidhu,et al. α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease , 2015, Neurobiology of Disease.
[7] C. Thompson,et al. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation , 2008, Proceedings of the National Academy of Sciences.
[8] A. Koong,et al. Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD , 2014, Cell reports.
[9] D. Ron,et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. , 2004, Genes & development.
[10] R. Hegele,et al. The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism , 2011, Nature Medicine.
[11] R. Kaufman,et al. A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells , 2010, Science Signaling.
[12] R. Kaufman,et al. The mammalian unfolded protein response. , 2003, Annual review of biochemistry.
[13] Randal J. Kaufman,et al. Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival , 2003, Molecular and Cellular Biology.
[14] Jae-Kwan Hwang,et al. Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes , 2008, Diabetes.
[15] L. Glimcher,et al. IRE1α activation protects mice against acetaminophen-induced hepatotoxicity , 2012, The Journal of experimental medicine.
[16] A. Kaser,et al. Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.
[17] Dustin J Maly,et al. Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress , 2014, Cell.
[18] L. Glimcher,et al. Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 , 2008, Science.
[19] R. Kaufman,et al. ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice , 2013, Diabetologia.
[20] D. Ron,et al. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains , 2013, Proceedings of the National Academy of Sciences.
[21] S. Ackerman,et al. Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP , 2005, Nature Genetics.
[22] M. Katze,et al. Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis , 2015, Diabetes.
[23] H. Heng,et al. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. , 2012, American journal of translational research.
[24] M. Montminy,et al. The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis , 2009, Nature.
[25] N. Morgan,et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes , 2012, Diabetologia.
[26] Xi Chen,et al. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages , 2010, Nature Immunology.
[27] L. Glimcher,et al. Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. , 2012, Cell metabolism.
[28] C. Hetz,et al. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases , 2014, Nature Reviews Neuroscience.
[29] C. Hetz,et al. Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. , 2012, Human molecular genetics.
[30] Barbara C. McGrath,et al. Insulin Secretion and Ca2+ Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin* , 2013, The Journal of Biological Chemistry.
[31] R. Kaufman,et al. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. , 2013, Gastroenterology.
[32] R. Kaufman,et al. Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins , 2006, PLoS biology.
[33] Jennifer E. Golden,et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response , 2014, ACS medicinal chemistry letters.
[34] B. S. Mohammed,et al. Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women , 2010, Diabetes.
[35] M. Bevan,et al. Differentiation during Acute Infection T Cell + XBP-1 Contributes to Effector CD8 Endoplasmic Reticulum Stress Regulator , 2008 .
[36] Yaosheng Chen,et al. Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator‐activated receptor γ , 2014, The FEBS journal.
[37] Xiaozhong Wang,et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.
[38] S. C. Colvin,et al. Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model , 2012, Diabetes.
[39] L. Eckmann,et al. Phosphorylation of eIF2&agr; Is Dispensable for Differentiation but Required at a Posttranscriptional Level for Paneth Cell Function and Intestinal Homeostasis in Mice , 2014, Inflammatory bowel diseases.
[40] Neal N. Iwakoshi,et al. The transcription factor XBP-1 is essential for the development and survival of dendritic cells , 2007, The Journal of experimental medicine.
[41] T Tabira,et al. A molecular chaperone inducer protects neurons from ER stress , 2008, Cell Death and Differentiation.
[42] D. Dinsdale,et al. Sustained translational repression by eIF2α-P mediates prion neurodegeneration , 2012, Nature.
[43] L. P. Vaites,et al. PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation , 2012, Molecular and Cellular Biology.
[44] H. Perlman,et al. Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis , 2013, The EMBO journal.
[45] Denise N. Bronner,et al. Endoplasmic Reticulum stress activates the inflammasome via NLRP 3-caspase-2 driven mitochondrial damage , 2015 .
[46] L. Glimcher,et al. Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion , 2011, Proceedings of the National Academy of Sciences.
[47] Nobutaka Hattori,et al. Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease , 2001, Science.
[48] D. Ron,et al. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. , 2013, Cell reports.
[49] R. Kaufman,et al. The impact of the endoplasmic reticulum protein-folding environment on cancer development , 2014, Nature Reviews Cancer.
[50] R. Kaufman,et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death , 2013, Nature Cell Biology.
[51] D. Lawrence,et al. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis , 2014, Science.
[52] M. Bevan,et al. Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection1 , 2008, The Journal of Immunology.
[53] J. Kushner,et al. PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis , 2012, Molecular and Cellular Biology.
[54] R. Kaufman,et al. IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. , 2012, Cell metabolism.
[55] Jason Chung,et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. , 2009, Cell metabolism.
[56] R. Kaufman,et al. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion , 2008, Proceedings of the National Academy of Sciences.
[57] A. Babour,et al. A Surveillance Pathway Monitors the Fitness of the Endoplasmic Reticulum to Control Its Inheritance , 2010, Cell.
[58] R. Rizza,et al. High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes , 2007, Diabetes.
[59] S. Henis-Korenblit,et al. Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans , 2015, eLife.
[60] M. Fukumoto,et al. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. , 2012, Metabolism: clinical and experimental.
[61] W. Bowen,et al. Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response , 2006 .
[62] J. Borén,et al. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. , 2015, Circulation research.
[63] Subramaniam Pennathur,et al. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. , 2008, The Journal of clinical investigation.
[64] Yong Liu,et al. PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism , 2011, Proceedings of the National Academy of Sciences.
[65] Randal J. Kaufman,et al. Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response , 2006, Cell.
[66] Katsuhiro Yoshikawa,et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. , 2013, Cell stem cell.
[67] G. Morgan,et al. Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress , 2015, Molecular and Cellular Biology.
[68] J. C. Love,et al. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells , 2009, The EMBO journal.
[69] M. Karin,et al. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. , 2014, Cancer cell.
[70] G. Shulman,et al. Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism , 2011, The Journal of Biological Chemistry.
[71] P. Greengard,et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. , 2012, Cell metabolism.
[72] L. Glimcher,et al. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.
[73] H. Tilg,et al. XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease , 2008, Cell.
[74] Maruf M. U. Ali,et al. Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling , 2015, eLife.
[75] Nathan H. Lents,et al. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. , 2007, Molecular cell.
[76] J. Whitehead,et al. Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress , 2014, Nature Medicine.
[77] T. Jahnke,et al. IRE 1 Signaling Affects Cell Fate During the Unfolded Protein Response , 2008 .
[78] A. Koromilas,et al. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications , 2014, Cell cycle.
[79] E. Sokol,et al. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. , 2014, Cancer discovery.
[80] H. Hauri,et al. Mutations in the ER–Golgi Intermediate Compartment Protein ERGIC-53 Cause Combined Deficiency of Coagulation Factors V and VIII , 1998, Cell.
[81] T. Graeber,et al. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. , 2013, Cancer research.
[82] P. Walter,et al. Gardner the Unfolded Protein Response Unfolded Proteins Are Ire 1-Activating Ligands That Directly Induce , 2011 .
[83] B. Yusta,et al. GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress , 2006 .
[84] Michael D. Pluth,et al. Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons , 2013, Science.
[85] J. Elmquist,et al. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. , 2014, Cell metabolism.
[86] R. Kaufman,et al. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. , 2007, Developmental cell.
[87] C. Hetz. The unfolded protein response: controlling cell fate decisions under ER stress and beyond , 2012, Nature Reviews Molecular Cell Biology.
[88] G. Lewis,et al. Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans , 2011, Diabetes.
[89] N. Volkmann,et al. The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells , 2015, PLoS biology.
[90] D. Ron,et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. , 2001, Molecular cell.
[91] M. Katze,et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.
[92] J. Graff,et al. Atf 4 Regulates Obesity , Glucose Homeostasis , and Energy Expenditure , 2009 .
[93] E McEwen,et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. , 2001, Molecular cell.
[94] Peter Walter,et al. Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response , 2011, Science.
[95] Michael Karin,et al. Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases , 2005, Cell.
[96] G. Morgan,et al. Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress , 2015, Molecular and Cellular Biology.
[97] M. Lang-Muritano,et al. Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene. , 2002, Diabetes.
[98] D. Scheuner,et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. , 2009, Cell metabolism.
[99] J. L. Quesne,et al. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity , 2015, Cell Death and Disease.
[100] Zhaohui Xu,et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response , 2006, Proceedings of the National Academy of Sciences.
[101] G. Lathrop,et al. EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome , 2000, Nature Genetics.
[102] D. Scheuner,et al. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development , 2009, Proceedings of the National Academy of Sciences.
[103] L. Glimcher,et al. XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. , 2010, Gastroenterology.
[104] R. Kaufman,et al. Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. , 2014, Biochimica et biophysica acta.
[105] S. Gygi,et al. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction , 2015, Science.
[106] Kezhong Zhang,et al. The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis , 2011, The EMBO journal.
[107] D. Scheuner,et al. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. , 2005, The Journal of clinical investigation.
[108] Dustin J Maly,et al. Allosteric Inhibition of the IRE 1 a RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress , 2014 .
[109] D. Mathis,et al. Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes , 2013, Science Translational Medicine.
[110] Rebecca C Taylor,et al. XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity , 2013, Cell.
[111] Hiderou Yoshida,et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. , 2007, Developmental cell.
[112] Chao Zhang,et al. IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response , 2007, Science.
[113] S. Beck,et al. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia , 2015, Nature Genetics.
[114] Kim Schneider,et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit , 2015, Science.
[115] L. Staudt,et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. , 2004, Immunity.
[116] Neal N. Iwakoshi,et al. Plasma cell differentiation requires the transcription factor XBP-1 , 2001, Nature.
[117] Lee H. Dicker,et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity , 2011, Nature.
[118] M. Zanetti,et al. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells , 2011, Proceedings of the National Academy of Sciences.
[119] J. Yates,et al. Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. , 2013, Cell reports.
[120] J. Graff,et al. Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure , 2009, Diabetes.
[121] Ernest Beutler,et al. Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[122] D. Scheuner,et al. Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2 , 2004, The EMBO journal.
[123] C. Hetz,et al. AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease. , 2012, Biochemical and biophysical research communications.
[124] K. Nader,et al. Pharmacological brake-release of mRNA translation enhances cognitive memory , 2013, eLife.
[125] A. Tardivel,et al. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway , 2012, Cell Death and Disease.
[126] A. Strasser,et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis , 2013, Cell Death and Differentiation.
[127] Michael T. McManus,et al. IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2 , 2012, Science.
[128] L. Glimcher,et al. IRE1 activation protects mice against acetaminophen-induced hepatotoxicity , 2012 .
[129] B. Liu,et al. MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4* , 2015, The Journal of Biological Chemistry.
[130] A. Yalçin,et al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity , 2015, Science Translational Medicine.
[131] Chandler A. Walker,et al. Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions , 2014, Cell.
[132] P. Fischer,et al. Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice , 2013, Science Translational Medicine.