Development and optimisation of a novel 3D fiber-based mesh for POP repair and regeneration

Hypothesis / aims of study Monofilament polypropylene meshes are the most frequently used devices for the repair of pelvic organ prolapse (POP). However, given the serious complications associated with their use, such as mesh erosion and shrinkage, pain, dyspareunia and infection, they are currently under the investigation of US Food and Drug Administration, which have also released multiple warnings [1]. To overcome the still open challenges in POP repair, natural polymers have been proposed in the recent literature. However, the clinical application of this class of polymers is also limited because of their rapid degradation rate [2]. Hence, the aim of this study was i) the optimisation of a needleless electrospinning technology toward ii) the development of a novel 3D mesh, based on the combination of a natural and a synthetic polymer, with appropriate mechanical strength, controlled degradation rate and customable antibacterial properties, for the repair of human pelvic floor.