Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease

[1]  G. Trinchieri,et al.  Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. , 2001, Clinical immunology.

[2]  S. Baranzini,et al.  Transcriptional Analysis of Multiple Sclerosis Brain Lesions Reveals a Complex Pattern of Cytokine Expression1 , 2000, The Journal of Immunology.

[3]  V. Rivera,et al.  Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. , 2000, International immunology.

[4]  Kenneth M. Murphy,et al.  Dendritic cell regulation of TH1-TH2 development , 2000, Nature Immunology.

[5]  Richard A. Rudick,et al.  Quantification of Self-Recognition in Multiple Sclerosis by Single-Cell Analysis of Cytokine Production1 , 2000, The Journal of Immunology.

[6]  S. Cook,et al.  Cytokine secretion profile of myelin basic protein-specific T cells in multiple sclerosis , 2000, Multiple sclerosis.

[7]  N. Sarvetnick,et al.  Cytokines that regulate autoimmune responses. , 1999, Current opinion in immunology.

[8]  V. Rivera,et al.  Interferon beta induces T-helper 2 immune deviation in MS , 1999, Neurology.

[9]  H. Link,et al.  Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines , 1999, Journal of Neuroimmunology.

[10]  F. Barkhof,et al.  Decreased interleukin‐10 and increased interleukin‐12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis , 1999, Annals of neurology.

[11]  S. Sriram,et al.  Superantigens augment antigen‐specific Th1 responses by inducing IL‐12 production in macrophages , 1999, Journal of leukocyte biology.

[12]  C. Pitcher,et al.  HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression , 1999, Nature Medicine.

[13]  C. Polman,et al.  Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients , 1999, Journal of Neuroimmunology.

[14]  John T. Chang,et al.  Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells , 1999, The Journal of experimental medicine.

[15]  D. Mason,et al.  Regulatory T Cells in the Control of Autoimmunity: the Essential Role of  Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes , 1999, The Journal of experimental medicine.

[16]  D. Beller,et al.  Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand Black/White F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain. , 1998, Journal of immunology.

[17]  P. Kalinski,et al.  The role of antigen-presenting cells in the regulation of allergen-specific T cell responses. , 1998, Current opinion in immunology.

[18]  V. Maino,et al.  Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis. , 1998, Journal of immunology.

[19]  D. E. Anderson,et al.  Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis , 1998, Journal of Neuroimmunology.

[20]  J. McCune,et al.  Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1 , 1998, Nature Medicine.

[21]  E. Shevach,et al.  An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease , 1998, The Journal of experimental medicine.

[22]  M. Clerici,et al.  Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis. , 1998, Journal of immunology.

[23]  P. Kivisäkk,et al.  Multiple sclerosis: myelin basic protein induced mRNA expression of proinflammatory cytokines in mononuclear cells is suppressed by interferon‐β 1b in vitro , 1997 .

[24]  A. Dalgleish Viruses and multiple sclerosis , 1997, Acta neurologica Scandinavica. Supplementum.

[25]  N. Sarvetnick,et al.  Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice , 1996, The Journal of experimental medicine.

[26]  H. Hartung,et al.  The immunopathogenesis of multiple sclerosis and Guillain‐Barré syndrome , 1996, Current opinion in neurology.

[27]  G. Marshall,et al.  Interferon-beta sub 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis , 1996, Neurology.

[28]  L Steinman,et al.  Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System , 1996, Cell.

[29]  S. Reingold,et al.  Defining the clinical course of multiple sclerosis , 1996, Neurology.

[30]  T. Olsson,et al.  Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. , 1996, Brain : a journal of neurology.

[31]  J. Strominger,et al.  Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein , 1995, Cell.

[32]  A. Broocks,et al.  Tumor necrosis factor‐α messenger RNA expression in patients with relapsing‐remitting multiple sclerosis is associated with disease activity , 1995, Annals of neurology.

[33]  G. Trinchieri Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.

[34]  H. McFarland,et al.  Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. , 1995, Critical reviews in clinical laboratory sciences.

[35]  H. Mcdevitt,et al.  Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. , 1995, Immunology today.

[36]  T. Olsson,et al.  Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis , 1994, Annals of neurology.

[37]  S. Miller,et al.  The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases. , 1994, Immunology today.

[38]  A. Broocks,et al.  Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis , 1994, Neurology.

[39]  D. Hafler,et al.  Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. , 1994, Journal of immunology.

[40]  B. Arnason Interferon beta in multiple sclerosis. , 1996, Neurology.

[41]  J. Kurtzke Epidemiologic evidence for multiple sclerosis as an infection , 1993, Clinical Microbiology Reviews.

[42]  D. Paty,et al.  Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis , 1993, Neurology.

[43]  C. Poser The pathogenesis of multiple sclerosis , 1993, Journal of the Neurological Sciences.

[44]  L. Hood,et al.  Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity , 1993, Cell.

[45]  T. Olsson,et al.  Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis , 1992, European journal of immunology.

[46]  T. Olsson,et al.  Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls , 1991, European journal of immunology.

[47]  T. Olsson,et al.  T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. , 1991, Journal of immunology.

[48]  A. Thompson,et al.  Major differences in the dynamics of primary and secondary progressive multiple sclerosis , 1991, Annals of neurology.

[49]  L. Kappos,et al.  Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals , 1990, Neurology.

[50]  T. Olsson,et al.  Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. , 1990, The Journal of clinical investigation.

[51]  Eric O Long,et al.  Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. , 1990, Journal of immunology.

[52]  T. Yokota,et al.  Cytokines: coordinators of immune and inflammatory responses. , 1990, Annual review of biochemistry.

[53]  D. Willenborg Experimental allergic encephalomyelitis in the Lewis rat: studies on the mechanism of recovery from disease and acquired resistance to reinduction. , 1979, Journal of immunology.