(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

[1]  G. Allan,et al.  2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists. , 2007, Bioorganic & medicinal chemistry letters.

[2]  J. Dalton,et al.  Chemistry and structural biology of androgen receptor. , 2005, Chemical reviews.

[3]  Duane D. Miller,et al.  Structural basis for antagonism and resistance of bicalutamide in prostate cancer , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  T. Nyrönen,et al.  Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain. , 2005, Journal of medicinal chemistry.

[5]  Y. Fradet.  Bicalutamide (Casodex®) in the treatment of prostate cancer , 2004, Expert review of anticancer therapy.

[6]  T. Sugino,et al.  Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells1 , 2000 .

[7]  S. Schaus,et al.  Asymmetric ring opening of meso epoxides with TMSCN catalyzed by (pybox)lanthanide complexes. , 2000, Organic letters.

[8]  F. Labrie,et al.  Androgen receptor antagonists (antiandrogens): structure-activity relationships. , 2000, Current medicinal chemistry.

[9]  L. Denis,et al.  Clinical Pharmacokinetics of the Antiandrogens and Their Efficacy in Prostate Cancer , 1998, Clinical pharmacokinetics.

[10]  G. Heinze,et al.  Topical cyproterone acetate treatment in women with acne: a placebo-controlled trial. , 1998, Archives of dermatology.

[11]  J. Dubois,et al.  Importance of sebaceous glands in cutaneous penetration of an antiandrogen: target effect of liposomes. , 1997, Journal of pharmaceutical sciences.

[12]  W. Bergfeld,et al.  Treatment of androgenic disorders in women: acne, hirsutism, and alopecia. , 1990, Cleveland Clinic journal of medicine.

[13]  G. Plewig,et al.  Hamster ear model for sebaceous glands. , 1977, The Journal of investigative dermatology.

[14]  J. C. Shaw.  Acne: effect of hormones on pathogenesis and management. , 2002, American journal of clinical dermatology.