3D printed structures with biomimicry mechanical characteristics for auricular cartilage growth

................................................................................................................................................................. V List of Figures ................................................................................................................................................... VIII List of Tables ....................................................................................................................................................... XI Abbreviations ..................................................................................................................................................... XII

[1]  D. Hutmacher,et al.  Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs , 2015, Advanced healthcare materials.

[2]  Stuart K Williams,et al.  Direct-write bioprinting three-dimensional biohybrid systems for future regenerative therapies. , 2011, Journal of biomedical materials research. Part B, Applied biomaterials.

[3]  Robert Langer,et al.  Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells , 2007, Proceedings of the National Academy of Sciences.

[4]  Dong-Woo Cho,et al.  Biofabrication: reappraising the definition of an evolving field , 2016, Biofabrication.

[5]  M. Kon,et al.  Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering , 2016, Stem Cell Research & Therapy.

[6]  R. Müller,et al.  Mechanical and biochemical mapping of human auricular cartilage for reliable assessment of tissue-engineered constructs. , 2015, Journal of biomechanics.

[7]  J Malda,et al.  Hydrogel-based reinforcement of 3D bioprinted constructs , 2016, Biofabrication.

[8]  Joseph P Vacanti,et al.  The tissue-engineered auricle: past, present, and future. , 2012, Tissue engineering. Part B, Reviews.

[9]  E. Schacht,et al.  Cell survival and proliferation after encapsulation in a chemically modified Pluronic® F127 hydrogel , 2013, Journal of biomaterials applications.

[10]  Dietmar W. Hutmacher,et al.  Comparison of the degradation of polycaprolactone and polycaprolactone–(β‐tricalcium phosphate) scaffolds in alkaline medium , 2007 .

[11]  A. Mikos,et al.  Electrospinning of polymeric nanofibers for tissue engineering applications: a review. , 2006, Tissue engineering.

[12]  P. Gatenholm,et al.  3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications. , 2015, Biomacromolecules.

[13]  Geunhyung Kim,et al.  A polycaprolactone/fish collagen/alginate biocomposite supplemented with phlorotannin for hard tissue regeneration , 2017 .

[14]  P. V. van Zuijlen,et al.  Cartilage Tissue Engineering: Preventing Tissue Scaffold Contraction Using a 3D-Printed Polymeric Cage. , 2016, Tissue engineering. Part C, Methods.

[15]  D. Cho,et al.  Three-Dimensional Cell Printing of Large-Volume Tissues: Application to Ear Regeneration. , 2017, Tissue engineering. Part C, Methods.

[16]  Farshid Guilak,et al.  Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. , 2004, Biomaterials.

[17]  M. Vallet‐Regí,et al.  In vitro biocompatibility assessment of poly(epsilon-caprolactone) films using L929 mouse fibroblasts. , 2004, Biomaterials.

[18]  Hon Fai Chan,et al.  3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures , 2015, Advanced materials.

[19]  Jinkee Hong,et al.  Inkjet-based multilayered growth factor-releasing nanofilms for enhancing proliferation of mesenchymal stem cells in vitro , 2017 .

[20]  Y. Ikada,et al.  Development of an artificial articular cartilage. , 1990, Clinical materials.

[21]  Pierpaolo Mastroiacovo,et al.  Microtia-anotia: a global review of prevalence rates. , 2011, Birth defects research. Part A, Clinical and molecular teratology.

[22]  Stuart Kyle,et al.  ‘Printability' of Candidate Biomaterials for Extrusion Based 3D Printing: State‐of‐the‐Art , 2017, Advanced healthcare materials.

[23]  James J. Yoo,et al.  Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications , 2012, Biofabrication.

[24]  Marco N Helder,et al.  Rapid attachment of adipose stromal cells on resorbable polymeric scaffolds facilitates the one‐step surgical procedure for cartilage and bone tissue engineering purposes , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[25]  Yu Ri Lee,et al.  Highly conductive and stretchable fiber interconnections using dry-spun carbon nanotube fibers modified with ionic liquid/poly(vinylidene fluoride) copolymer composite , 2019, Composites Science and Technology.

[26]  R. L. Walton,et al.  Auricular reconstruction for microtia: Part II. Surgical techniques. , 2002, Plastic and reconstructive surgery.

[27]  D. Hutmacher,et al.  The return of a forgotten polymer : Polycaprolactone in the 21st century , 2009 .

[28]  J. Malda,et al.  Biofabrication of multi-material anatomically shaped tissue constructs , 2013, Biofabrication.

[29]  E. Beahm,et al.  Auricular reconstruction for microtia: part I. Anatomy, embryology, and clinical evaluation. , 2002, Plastic and reconstructive surgery.

[30]  Mark A. Randolph,et al.  Design of composite scaffolds and three-dimensional shape analysis for tissue-engineered ear , 2013, Journal of The Royal Society Interface.

[31]  Dietmar W. Hutmacher,et al.  Design, fabrication and characterization of PCL electrospun scaffolds—a review , 2011 .

[32]  D. Cho,et al.  3D printing of composite tissue with complex shape applied to ear regeneration , 2014, Biofabrication.

[33]  Shufang Zhang,et al.  A Gelatin-sulfonated Silk Composite Scaffold based on 3D Printing Technology Enhances Skin Regeneration by Stimulating Epidermal Growth and Dermal Neovascularization , 2017, Scientific Reports.

[34]  Xiaofeng Cui,et al.  Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA , 2015, Biotechnology Letters.

[35]  Tim B. F. Woodfield,et al.  Thiol–Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies , 2017, Advanced materials.

[36]  R. Bank,et al.  Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future , 2008, Journal of cellular and molecular medicine.

[37]  Zohreh Izadifar,et al.  Analyzing Biological Performance of 3D-Printed, Cell-Impregnated Hybrid Constructs for Cartilage Tissue Engineering. , 2016, Tissue engineering. Part C, Methods.

[38]  G. Wallace,et al.  Enzymatic degradation of graphene/polycaprolactone materials for tissue engineering , 2015 .

[39]  Y. S. Zhang,et al.  Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives. , 2017, Biomaterials.

[40]  V Mironov,et al.  Biofabrication: a 21st century manufacturing paradigm , 2009, Biofabrication.

[41]  A. Seifalian,et al.  Biomechanical Characterisation of the Human Auricular Cartilages; Implications for Tissue Engineering , 2016, Annals of Biomedical Engineering.

[42]  Dong-Yol Yang,et al.  Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration. , 2008, Acta biomaterialia.

[43]  Ralph Müller,et al.  Quantitative evaluation of mechanical properties in tissue-engineered auricular cartilage. , 2014, Tissue engineering. Part B, Reviews.

[44]  Ralph Müller,et al.  Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting. , 2014, Acta biomaterialia.

[45]  Andre Sharon,et al.  3D bioprinting of GelMA scaffolds triggers mineral deposition by primary human osteoblasts , 2017, Biofabrication.

[46]  James J. Yoo,et al.  A 3D bioprinting system to produce human-scale tissue constructs with structural integrity , 2016, Nature Biotechnology.

[47]  Aleksandr Ovsianikov,et al.  Development of the Biopen : a handheld device for surgical printing of adipose stem cells at a chondral wound site , 2016 .

[48]  Cunxian Song,et al.  The in vivo degradation, absorption and excretion of PCL-based implant. , 2006, Biomaterials.

[49]  Zohreh Izadifar,et al.  Modulating mechanical behaviour of 3D-printed cartilage-mimetic PCL scaffolds: influence of molecular weight and pore geometry , 2016, Biofabrication.

[50]  Ali Khademhosseini,et al.  Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms , 2016, Nature Protocols.

[51]  Dong-Woo Cho,et al.  Development of a 3D cell printed structure as an alternative to autologs cartilage for auricular reconstruction. , 2017, Journal of biomedical materials research. Part B, Applied biomaterials.

[52]  Jos Malda,et al.  Reinforcement of hydrogels using three-dimensionally printed microfibres , 2015, Nature Communications.

[53]  R. Tuan,et al.  A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. , 2005, Biomaterials.

[54]  Paulo G Coelho,et al.  The technique for 3D printing patient-specific models for auricular reconstruction. , 2017, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[55]  Keekyoung Kim,et al.  3D bioprinting for engineering complex tissues. , 2016, Biotechnology advances.

[56]  Ralph Müller,et al.  Mechanical evaluation of bacterial nanocellulose as an implant material for ear cartilage replacement. , 2013, Journal of the mechanical behavior of biomedical materials.

[57]  L. Bonassar,et al.  Analysis of bending behavior of native and engineered, auricular and costal cartilage , 2001, Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201).

[58]  H. Fischer,et al.  Supporting Biomaterials for Articular Cartilage Repair , 2012, Cartilage.

[59]  Jung Min Lee,et al.  Artificial Auricular Cartilage Using Silk Fibroin and Polyvinyl Alcohol Hydrogel , 2017, International journal of molecular sciences.

[60]  Anthony Atala,et al.  3D bioprinting of tissues and organs , 2014, Nature Biotechnology.

[61]  Wim E Hennink,et al.  25th Anniversary Article: Engineering Hydrogels for Biofabrication , 2013, Advanced materials.

[62]  Swee Hin Teoh,et al.  Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. , 2009, Journal of biomedical materials research. Part A.

[63]  K. Shakesheff,et al.  Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing , 2016, Biofabrication.

[64]  M Gelinsky,et al.  A definition of bioinks and their distinction from biomaterial inks , 2018, Biofabrication.