Characterization of a new radioiodinated probe for the α2C adrenoceptor in the mouse brain

[1]  J. Docherty.  Subtypes of functional a 1- and a 2-adrenoceptors , 1998 .

[2]  M. Scheinin,et al.  Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies. , 1998, Molecular pharmacology.

[3]  K. Lynch,et al.  Localization ofα2c-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system , 1998, Neuroscience.

[4]  J. Wikberg,et al.  [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. , 1998, European journal of pharmacology.

[5]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[6]  E. Vizi,et al.  α 2A subtype of presynaptic α 2-Adrenoceptors modulates the release of [3H]-noradrenaline from rat spinal cord , 1997, Brain Research Bulletin.

[7]  R. Eglen,et al.  Assessment of the role of α2‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice , 1997, British journal of pharmacology.

[8]  J. Wikberg,et al.  Quantification of alpha2A and alpha2C adrenoceptors in the rat striatum and in different regions of the spinal cord. , 1997, Acta physiologica Scandinavica.

[9]  G. Ordway,et al.  Reduced expression of alpha2C-adrenoceptors in rat striatum following antisense oligodeoxynucleotide infusion. , 1997, Brain research. Molecular brain research.

[10]  F. Leslie,et al.  α2B Adrenoceptor mRNA expression during rat brain development , 1997 .

[11]  S. Schaak,et al.  HepG2 and SK-N-MC: two human models to study alpha-2 adrenergic receptors of the alpha-2C subtype. , 1997, The Journal of pharmacology and experimental therapeutics.

[12]  J. Levine,et al.  Multiple Receptors Involved in Peripheral α2, μ, and A1 Antinociception, Tolerance, and Withdrawal , 1997, The Journal of Neuroscience.

[13]  G. Barsh,et al.  Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist , 1997 .

[14]  F. Leslie,et al.  Expression of α 2 adrenoceptors during rat brain development—II. α 2C messenger RNA expression and [3H]rauwolscine binding , 1996, Neuroscience.

[15]  L. Callado,et al.  [3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney. , 1996, European journal of pharmacology.

[16]  R. Fremeau,et al.  EXPRESSION OF α2-ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS , 1996, Neuroscience.

[17]  R. Stornetta,et al.  Distribution of α2C‐adrenergic receptor‐like immunoreactivity in the rat central nervous system , 1996 .

[18]  L. Macmillan,et al.  Central Hypotensive Effects of the α2a-Adrenergic Receptor Subtype , 1996, Science.

[19]  G. Barsh,et al.  Cardiovascular Regulation in Mice Lacking α2-Adrenergic Receptor Subtypes b and c , 1996, Science.

[20]  T. Hökfelt,et al.  The distribution and significance of CNS adrenoceptors examined with in situ hybridization. , 1996, Trends in pharmacological sciences.

[21]  J. Wikberg,et al.  Identification of drugs subtype-selective for α2A-, α2B-, and α2C-adrenoceptors in the pig cerebellum and kidney cortex , 1995 .

[22]  J. Hieble,et al.  Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. , 1995, Journal of medicinal chemistry.

[23]  M. Scheinin,et al.  Molecular pharmacology of α2-adrenoceptor subtypes , 1995 .

[24]  G. Barsh,et al.  Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. , 1995, Molecular pharmacology.

[25]  M. Michel,et al.  Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. , 1995, The Journal of pharmacology and experimental therapeutics.

[26]  J. Levine,et al.  Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat , 1995, Neuroscience.

[27]  M. Scheinin,et al.  Recombinant human alpha 2-adrenoceptor subtypes: comparison of [3H]rauwolscine, [3H]atipamezole and [3H]RX821002 as radioligands. , 1995, Biochimica et biophysica acta.

[28]  R. Neubig,et al.  The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. , 1994, The Journal of pharmacology and experimental therapeutics.

[29]  P. Molinoff,et al.  International Union of Pharmacology nomenclature of adrenoceptors. , 1994, Pharmacological reviews.

[30]  D. Bylund,et al.  Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes. , 1994, The Journal of pharmacology and experimental therapeutics.

[31]  J. Devedjian,et al.  Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs. , 1994, European journal of pharmacology.

[32]  U. Schambra,et al.  Distribution of α2-adrenergic receptor subtype gene expression in rat brain , 1994 .

[33]  S. McCune,et al.  Expression of multiple alpha adrenergic receptor subtype messenger RNAs in the adult rat brain , 1993, Neuroscience.

[34]  M. Scheinin,et al.  Use of recombinant human α2-adrenoceptors to characterize subtype selectivity of antagonist binding , 1993 .

[35]  M. Koulu,et al.  Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist. , 1993, Pharmacology & toxicology.

[36]  T. Hökfelt,et al.  Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study , 1993, The Journal of comparative neurology.

[37]  K Zilles,et al.  Regional distribution and heterogeneity of alpha-adrenoceptors in the rat and human central nervous system. , 1993, Journal fur Hirnforschung.

[38]  C. Mathis,et al.  Quantitative in vitro and ex vivo autoradiography of the α2-adrenoceptor antagonist [3H]atopamezole , 1992 .

[39]  G. Barsh,et al.  Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor , 1992 .

[40]  J. Wikberg,et al.  [3H]‐MK 912 binding delineates two α2‐adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d α2‐adrenoceptor , 1992 .

[41]  A. Hudson,et al.  Characterization and autoradiographical localization of non‐adrenoceptor idazoxan binding sites in the rat brain , 1992, British journal of pharmacology.

[42]  M. Caron,et al.  Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. , 1992, Molecular pharmacology.

[43]  G. Barsh,et al.  Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. , 1992, Molecular pharmacology.

[44]  D. Bylund,et al.  Differential localization of α 2-adrenergic receptor subtypes in brain , 1992, Pharmacology Biochemistry and Behavior.

[45]  M. Hamon,et al.  Central serotonin1A receptors: Respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry, radioimmunohistochemistry and autoradiographic mapping in the rat brain , 1991, Neurochemistry International.

[46]  G. Vauquelin,et al.  Autoradiographic distribution of α 2 adrenoceptors, NAIBS, and 5-HT1A receptors in human brain using [3H]idazoxan and [3H]rauwolscine , 1991, Brain Research.

[47]  J. Harrison,et al.  Pharmacological characterization of rat alpha 2-adrenergic receptors. , 1991, Molecular pharmacology.

[48]  G. Vauquelin,et al.  [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. , 1991, European journal of pharmacology.

[49]  D. Langin,et al.  Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites. , 1990, Molecular pharmacology.

[50]  M. Spedding,et al.  α2‐Adrenoceptor subtypes and imidazoline‐like binding sites in the rat brain , 1990 .

[51]  G. Vauquelin,et al.  [3H]Rauwolscine labels α2-adrenoceptors and 5-HT1A receptors in human cerebral cortex , 1989 .

[52]  T. Svensson,et al.  Clonidine regularizes substantia nigra dopamine cell firing. , 1988, Life sciences.

[53]  F. Leslie,et al.  Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain. , 1987, The Journal of pharmacology and experimental therapeutics.

[54]  S. Loughlin,et al.  Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain. , 1987, The Journal of pharmacology and experimental therapeutics.

[55]  R. Graham,et al.  Synthesis and characterization of a high affinity radioiodinated probe for the alpha 2-adrenergic receptor. , 1986, Molecular pharmacology.

[56]  M. Kuhar,et al.  Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents , 1984, Brain Research Reviews.

[57]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .