Decision to deploy coronary reperfusion is not affected by the volume of ST-segment elevation myocardial infarction patients managed by prehospital emergency medical teams.

OBJECTIVE Mortality in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with the volume of activity of percutaneous coronary intervention (PCI) facilities. This observational study investigated whether the coronary reperfusion-decision rate is associated with the volume of activity in a prehospital emergency setting. METHODS Prospectively collected data for the period 2003-2013 were extracted from a regional registry of all STEMI patients handled by eight dispatch centers (SAMUs) in and around Paris [41 mobile ICU (MICUs)]. A possible association between volume of activity (number of STEMIs) and coronary reperfusion-decision rate, and subsidiarily between volume of activity and choice of technique (fibrinolysis vs. primary PCI), were investigated. Explanatory factors (patient age, sex, delay between pain onset and first medical contact, and access to a PCI facility) were analyzed in a multivariate analysis. RESULTS Overall, 18 162 patients; male/female 3.5/1; median age 62 (52-72) years were included in the analysis. The median number of STEMIs per MICU was 339 (IQ 220-508) and that of reperfusion-decisions was 94% (91-95). There was no association between the decision rate and the number of STEMIs (P=0.1). However, the decision rate was associated with age, sex, delay, and access to a PCI facility (P<0.0001) in a highly significant way. Fibrinolysis was a more frequent option for low-volume (remoter PCI facilities) than high-volume MICUs (30 vs. 16%). CONCLUSION The decision of coronary reperfusion in a prehospital emergency setting depended on patient characteristics, delay between pain onset and first medical contact, and access to a PCI facility, but not on volume of activity. Promoting fibrinolysis use in underserved areas might help increase the reperfusion-decision rate.

[1]  M. Jeng,et al.  The relationship between physician case volume and in-hospital mortality of critically ill children with a diagnosis of pneumonia: a cross-sectional observational analytical study. , 2014, Journal of critical care.

[2]  P. Armstrong,et al.  Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction. , 2013, The New England journal of medicine.

[3]  E. Topol,et al.  Facilitated PCI in patients with ST-elevation myocardial infarction. , 2008, The New England journal of medicine.

[4]  F. Lapostolle,et al.  International EMS systems: France. , 2004, Resuscitation.

[5]  S. Pocock,et al.  Bivalirudin started during emergency transport for primary PCI. , 2013, The New England journal of medicine.

[6]  H. Horiguchi,et al.  Relationship between Hospital Volume and Early Outcomes in Acute Ischemic Stroke Patients Treated with Recombinant Tissue Plasminogen Activator , 2015, International journal of stroke : official journal of the International Stroke Society.

[7]  C. Newgard,et al.  Increased Trauma Center Volume Is Associated With Improved Survival After Severe Injury: Results of a Resuscitation Outcomes Consortium Study , 2014, Annals of surgery.

[8]  X. Jouven,et al.  Female gender is an independent predictor of in-hospital mortality after STEMI in the era of primary PCI: insights from the greater Paris area PCI Registry. , 2011, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[9]  F. Lapostolle,et al.  Augmentation du taux de décision de reperfusion myocardique des patients ayant un syndrome coronaire aigu avec sus-décalage du segment ST. Analyse du registre e-MUST (2002 à 2010) des SAMU/SMUR d’Île-de-France , 2015 .

[10]  D. Atar,et al.  ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation , 2013 .

[11]  J. Ferrières,et al.  Association of changes in clinical characteristics and management with improvement in survival among patients with ST-elevation myocardial infarction. , 2012, JAMA.

[12]  David P Miller,et al.  Hospital Delays in Reperfusion for ST-Elevation Myocardial Infarction: Implications When Selecting a Reperfusion Strategy , 2006, Circulation.

[13]  X. Jouven,et al.  Outcomes of primary percutaneous coronary interventions in nonagenarians with acute myocardial infarction. , 2015, International journal of cardiology.

[14]  M. Morice,et al.  Is the volume-outcome relation still an issue in the era of PCI with systematic stenting? Results of the greater Paris area PCI registry. , 2006, European heart journal.

[15]  F. Lapostolle,et al.  Prise en charge des syndromes coronaires aigus : une filière de soins structurée par la recherche clinique , 2015 .

[16]  B. McNally,et al.  Increasing hospital volume is not associated with improved survival in out of hospital cardiac arrest of cardiac etiology. , 2012, Resuscitation.

[17]  P. Steg,et al.  Impact of Prehospital Thrombolysis for Acute Myocardial Infarction on 1-Year Outcome: Results From the French Nationwide USIC 2000 Registry , 2004, Circulation.

[18]  E. Vicaut,et al.  Prehospital ticagrelor in ST-segment elevation myocardial infarction. , 2014, The New England journal of medicine.