TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer.

[1]  M. Loda,et al.  Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP , 2007, Modern Pathology.

[2]  M. Loda,et al.  CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. , 2006, The Journal of molecular diagnostics : JMD.

[3]  P. Laird,et al.  CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer , 2006, Nature Genetics.

[4]  M. Loda,et al.  CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies , 2006, Gut.

[5]  M. Loda,et al.  Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. , 2006, Neoplasia.

[6]  R. Sandler,et al.  Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers , 2006, International journal of cancer.

[7]  Shuji Ogino,et al.  Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. , 2006, The Journal of molecular diagnostics : JMD.

[8]  M. Loda,et al.  Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component , 2006, Modern Pathology.

[9]  W. Willett,et al.  Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. , 2005, Journal of the National Cancer Institute.

[10]  J. Minna,et al.  DNA methylation-associated inactivation of TGFβ-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers , 2005, British journal of cancer.

[11]  R. Wolff,et al.  Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. , 2005, Gastroenterology.

[12]  M. Loda,et al.  Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. , 2005, The Journal of molecular diagnostics : JMD.

[13]  J. Jass.  Serrated adenoma of the colorectum and the DNA-methylator phenotype , 2005, Nature Clinical Practice Oncology.

[14]  Tsung-Teh Wu,et al.  Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. , 2005, Cancer research.

[15]  Graham A. Colditz,et al.  The Nurses' Health Study: lifestyle and health among women , 2005, Nature Reviews Cancer.

[16]  A. Fernández-Peralta,et al.  Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability. , 2005, Cancer genetics and cytogenetics.

[17]  C. Compton,et al.  Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers , 2004, International journal of cancer.

[18]  J. Issa.  CpG island methylator phenotype in cancer , 2004, Nature Reviews Cancer.

[19]  Lawrence J. Burgart,et al.  Development of a Fluorescent Multiplex Assay for Detection of MSI-High Tumors , 2004, Disease markers.

[20]  Il-Jin Kim,et al.  Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines , 2004, Oncogene.

[21]  Hyeon Joo Lee,et al.  Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma , 2004, Laboratory Investigation.

[22]  W. Grady.  Genomic instability and colon cancer , 2004, Cancer and Metastasis Reviews.

[23]  R. Urrutia,et al.  Growth inhibitory signalling by TGFbeta is blocked in Ras-transformed intestinal epithelial cells at a post-receptor locus. , 2003, Cellular signalling.

[24]  S. Neuhausen,et al.  Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability , 2002, Genes, chromosomes & cancer.

[25]  P J Catalano,et al.  Molecular predictors of survival after adjuvant chemotherapy for colon cancer. , 2001, The New England journal of medicine.

[26]  E. Friedman,et al.  Oncogenic Ki-ras Confers a More Aggressive Colon Cancer Phenotype through Modification of Transforming Growth Factor-β Receptor III* , 2001, The Journal of Biological Chemistry.

[27]  S. Oldham,et al.  Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling. , 2000, Neoplasia.

[28]  P. Laird,et al.  MethyLight: a high-throughput assay to measure DNA methylation. , 2000, Nucleic acids research.

[29]  N. Ahuja,et al.  Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Yoshiaki Ito.  Molecular basis of tissue‐specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF , 1999, Genes to cells : devoted to molecular & cellular mechanisms.

[31]  J. Massagué,et al.  Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells* , 1999, The Journal of Biological Chemistry.

[32]  J. Herman,et al.  CpG island methylator phenotype in colorectal cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[33]  R. Hamelin,et al.  Mutation of the transforming growth factor‐β type II receptor gene in right‐sided colorectal cancer: relationship to clinicopathological features and genetic alterations , 1998, The Journal of pathology.

[34]  K. Kinzler,et al.  Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. , 1995, Cancer research.

[35]  K. Kinzler,et al.  Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.