A case of surgical treatment for hepatocellular carcinoma that developed in a chronic hepatitis C patient who had shown sustained virological response to interferon 11 years before

症例は66歳，男性．11年前にC型慢性肝炎にてインターフェロン療法を施行され，ウイルス学的著効（sustained virological response, SVR）を得ていた．発熱を主訴に近医受診し，腹部超音波検査にて肝S8/5に腫瘤を指摘され当科紹介となった．B型肝炎ウイルスマーカーはHBs抗原陰性，HBs抗体陽性，HBe抗原陰性，HBe抗体陰性，HBc抗体陽性で，C型肝炎ウイルスマーカーはHCV-RNA定性陰性，HCV-RNA定量0.5 KIU/ml未満，HCV抗体陽性，Group 2であった．CT，MRIでも同様の肝腫瘤を認め，PIVKA-IIの上昇もあり肝細胞癌の診断にて肝右葉切除術施行．経過良好につき術18病日で退院した．今回我々は，C型慢性肝炎に対するIFN療法にてSVRが得られ，11年を経過して肝細胞癌を発症，肝切除を施行した1例を経験したので，文献的考察とともに報告する．

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