Plasma Polymerized Silylated Ciprofloxacin as an Antibiotic Coating

Locally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e.g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating usingN,O-bis-tert-butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa, and S. aureus.

[1]  F. Hsieh,et al.  Bacterial inactivation using a low-temperature atmospheric plasma brush sustained with argon gas. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[2]  E. Amanatides,et al.  Staphylococcus epidermidis adhesion to He, He/O(2) plasma treated PET films and aged materials: contributions of surface free energy and shear rate. , 2008, Colloids and surfaces. B, Biointerfaces.

[3]  Carla Renata Arciola,et al.  The significance of infection related to orthopedic devices and issues of antibiotic resistance. , 2006, Biomaterials.

[4]  S. Lee,et al.  WATER-REPELLENT IMPROVEMENT OF POLYESTER FIBER VIA RADIO FREQUENCY PLASMA TREATMENT WITH ARGON/HEXAMETHYLDISILOXANE (HMDSO) AT ATMOSPHERIC PRESSURE , 2009 .

[5]  Carla Renata Arciola,et al.  Advancements in molecular epidemiology of implant infections and future perspectives. , 2007, Biomaterials.

[6]  W. Zingg,et al.  Central venous catheter-associated infections. , 2008, Best practice & research. Clinical anaesthesiology.

[7]  A. Montali.  Antibacterial coating systems. , 2006, Injury.

[8]  B. Ratner,et al.  Design of infection-resistant antibiotic-releasing polymers: I. Fabrication and formulation. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[9]  J. Werner,et al.  Microstructure and optical properties of plasmapolymer thin films with embedded silver nanoparticles , 1995 .

[10]  John C. Lindon,et al.  Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy , 1998 .

[11]  J. Schierholz,et al.  Implant infections: a haven for opportunistic bacteria. , 2001, The Journal of hospital infection.

[12]  Y. Missirlis,et al.  Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. , 2004, European cells & materials.

[13]  David W Grainger,et al.  Drug/device combinations for local drug therapies and infection prophylaxis. , 2006, Biomaterials.

[14]  M. Zilberman,et al.  Antibiotic-eluting medical devices for various applications. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[15]  J. Beuth,et al.  Adherent bacteria and activity of antibiotics. , 1999, The Journal of antimicrobial chemotherapy.

[16]  A Delgado,et al.  Ciprofloxacin implants for bone infection. In vitro-in vivo characterization. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[17]  E. Amanatides,et al.  Plasma surface treatment of polyethylene terephthalate films for bacterial repellence , 2006 .

[18]  M. Bourham,et al.  Plasma and Antimicrobial Treatment of Nonwoven Fabrics for Surgical Gowns , 2004 .

[19]  S. Tamilvanan,et al.  The potential of lipid- and polymer-based drug delivery carriers for eradicating biofilm consortia on device-related nosocomial infections. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[20]  N. Khardori,et al.  Biofilms in device-related infections , 1995, Journal of Industrial Microbiology.

[21]  J. Blondeau,et al.  In vitro activity of 19 antimicrobial agents against 3513 nosocomial pathogens collected from 48 Canadian medical centres. The Canadian Antimicrobial Study Group. , 2000, International journal of antimicrobial agents.

[22]  B. Ratner,et al.  Design of infection-resistant antibiotic-releasing polymers. II. Controlled release of antibiotics through a plasma-deposited thin film barrier. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[23]  B. Mcnamara,et al.  PECVD of biocompatible coatings on 316L stainless steel , 2005 .

[24]  Yann Chevolot,et al.  Surface modification of PVC endotracheal tubes by oxygen glow discharge to reduce bacterial adhesion , 2003 .

[25]  Mukesh Doble,et al.  Biofilm formation, bacterial adhesion and host response on polymeric implants—issues and prevention , 2008, Biomedical materials.

[26]  G. Socrates,et al.  Infrared and Raman characteristic group frequencies : tables and charts , 2001 .

[27]  Junying Chen,et al.  Plasma-surface modification of biomaterials , 2002 .

[28]  C. Pulgarin,et al.  Antibacterial textiles prepared by RF-plasma and vacuum-UV mediated deposition of silver , 2003 .

[29]  Renee V. Goreham,et al.  Antibacterial surfaces by adsorptive binding of polyvinyl-sulphonate-stabilized silver nanoparticles , 2010, Nanotechnology.

[30]  G. Reid,et al.  Biofilms in infectious disease and on medical devices. , 1999, International journal of antimicrobial agents.