An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells

[1]  T. Aune,et al.  Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[2]  T. Aune,et al.  Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S. Reddy,et al.  Inflammatory bowel disease in African Americans. , 2003, Inflammatory bowel diseases.

[4]  B. Komm,et al.  Evaluation of an Estrogen Receptor-β Agonist in Animal Models of Human Disease , 2003 .

[5]  D. Longo,et al.  Effect of Promoter Methylation on the Regulation of IFN-γ Gene During In Vitro Differentiation of Human Peripheral Blood T Cells into a Th2 Population , 2003, The Journal of Immunology.

[6]  J. Margolick,et al.  A tumor necrosis factor-α-inducible promoter variant of interferon-γ accelerates CD4+ t cell depletion in human immunodeficiency virus-1-infected individuals , 2003 .

[7]  A. Goris,et al.  Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy? , 2003, Trends in pharmacological sciences.

[8]  S. Targan,et al.  CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells , 2003 .

[9]  E. Verdu,et al.  Modulatory effects of estrogen in two murine models of experimental colitis. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[10]  C. Winkler,et al.  A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription , 2002, Genes and Immunity.

[11]  P. Holt,et al.  Differential Patterns of Methylation of the IFN-γ Promoter at CpG and Non-CpG Sites Underlie Differences in IFN-γ Gene Expression Between Human Neonatal and Adult CD45RO− T Cells1 , 2002, The Journal of Immunology.

[12]  K. Korach,et al.  Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. , 2002, Molecular endocrinology.

[13]  R. Sandler,et al.  Crohn's disease: does race matter? , 2000, American Journal of Gastroenterology.

[14]  T. Macdonald,et al.  Enhancing Lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. , 1999, Gastroenterology.

[15]  E. Benveniste,et al.  The Transcription Factors Sp1, Sp3, and AP-2 Are Required for Constitutive Matrix Metalloproteinase-2 Gene Expression in Astroglioma Cells* , 1999, The Journal of Biological Chemistry.

[16]  S. Targan,et al.  CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation. , 1999, Journal of immunology.

[17]  G. Sathya,et al.  Sequence Requirements for Estrogen Receptor Binding to Estrogen Response Elements* , 1998, The Journal of Biological Chemistry.

[18]  A. Santoni,et al.  Vitamin D3: a transcriptional modulator of the interferon‐γ gene , 1998 .

[19]  S. Baylin,et al.  Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production , 1998, Molecular and Cellular Biology.

[20]  S. Targan,et al.  Activation of the CD2 pathway in lamina propria T cells up-regulates functionally active AP-1 binding to the IL-2 promoter, resulting in messenger RNA transcription and IL-2 secretion. , 1998, Journal of immunology.

[21]  B. Ludviksson,et al.  Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation , 1997 .

[22]  T. Aune,et al.  Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells , 1997, Molecular and cellular biology.

[23]  W. M. Weaver,et al.  The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells* , 1996, The Journal of Biological Chemistry.

[24]  A. Sica,et al.  Retinoic Acid-induced Transcriptional Modulation of the Human Interferon-γ Promoter* , 1996, The Journal of Biological Chemistry.

[25]  F. Powrie,et al.  T cells in inflammatory bowel disease: protective and pathogenic roles. , 1995, Immunity.

[26]  A. Sica,et al.  Negative Transcriptional Regulation of the Interferon-γ Promoter by Glucocorticoids and Dominant Negative Mutants of c-Jun (*) , 1995, The Journal of Biological Chemistry.

[27]  D. Lewis,et al.  Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells , 1995 .

[28]  S. Targan,et al.  Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. , 1995, Journal of immunology.

[29]  R. Sartor,et al.  Cytokines in intestinal inflammation: pathophysiological and clinical considerations. , 1994, Gastroenterology.

[30]  F. Peale,et al.  Cooperative estrogen receptor interaction with consensus or variant estrogen responsive elements in vitro. , 1992, Cancer research.

[31]  K. Korach,et al.  Uterine estrogen receptor-DNA complexes: effects of different ERE sequences, ligands, and receptor forms. , 1991, Molecular endocrinology.

[32]  S. Meuer,et al.  Differential responsiveness to CD3‐Ti vs. CD2‐dependent activation of human intestinal T lymphocytes , 1990, European journal of immunology.

[33]  D. Lewis,et al.  Gamma‐interferon: an immunoregulatory lymphokine with immunotherapeutic potential , 1990, The Pediatric infectious disease journal.

[34]  S. Targan,et al.  Human mucosal cytotoxic effector cells. , 1987, Gastroenterology.

[35]  Gerhart U. Ryffel,et al.  An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells , 1986, Cell.

[36]  P. Sehgal,et al.  Primary structural repeats in human and in murine γ-interferon , 1986 .

[37]  J. Keith,et al.  Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[38]  B. Komm,et al.  Evaluation of an estrogen receptor-beta agonist in animal models of human disease. , 2003, Endocrinology.

[39]  J. Margolick,et al.  A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. , 2003, Journal of Infectious Diseases.

[40]  S. Targan,et al.  CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells. , 2003, European Journal of Immunology.

[41]  P. Holt,et al.  Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. , 2002, Journal of immunology.

[42]  S. Targan,et al.  Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression. , 2000, Journal of immunology.

[43]  R. Sandler,et al.  Crohn's disease: does race matter? The Mid-Atlantic Crohn's Disease Study Group. , 2000, The American journal of gastroenterology.

[44]  A. Santoni,et al.  Vitamin D3: a transcriptional modulator of the interferon-gamma gene. , 1998, European journal of immunology.

[45]  B. Ludviksson,et al.  Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. , 1997, Immunology today.

[46]  C. Fiocchi,et al.  Hypoproliferative human lamina propria T cells retain the capacity to secrete lymphokines when stimulated via CD2/CD28 pathways. , 1996, Proceedings of the Association of American Physicians.

[47]  A. Sica,et al.  Retinoic acid-induced transcriptional modulation of the human interferon-gamma promoter. , 1996, The Journal of biological chemistry.

[48]  H. Young,et al.  Role of interferon-gamma in immune cell regulation. , 1995, Journal of leukocyte biology.

[49]  P. Sehgal,et al.  Primary structural repeats in human and in murine gamma-interferon. , 1986, Journal of Interferon Research.