“Spectrophotometric Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling Reaction”

A fast and sensitive spectral analysis method has been developed to estimate microscopic amounts of Trifluoperazine Hydrochloride in an aqueous medium. The method is based on oxidative coupling reaction between Trifluoperazine Hydrochloride and 2-nitroso-1-naphthol-4-sulfonic acid as an Reagent with the presence of the oxidized agent potassium persulfate at pH= 4.2. The resulting product is red, which is absorbed at the wavelength of 500nm, in distilled water and is stable for 80 minutes. The Bear-Lambert Act follows the concentration range of 12–36 µg/mL. The value of the MLM 6726 L.mole-1.cm-1, Sandel significance value of 0.07143 µg/cm2, the relative standard deviation does not exceed RS =0.9623, the relative error does not exceed RE = 0.8157, and the quantum limit 9.5x10-7 µg/mL, the detection limit 2.85×10-7 µg/mL, association coefficient R=0.9995, estimation coefficient R2=0.9989. The developed method successfully applied to estimate Trifluoperazine Hydrochloride in the pharmaceutical drug Stellasil (5mg).