Mismatch repair deficiency in Lynch syndrome‐associated colorectal adenomas is more prevalent in older patients

The aim of this study was to examine the expression of mismatch repair (MMR) proteins in Lynch syndrome (LS)‐associated colorectal adenomas and to evaluate their relationship with clinicopathological variables and potential utility in LS screening.

[1]  R. Pai,et al.  Germline MLH1 Mutations Are Frequently Identified in Lynch Syndrome Patients With Colorectal and Endometrial Carcinoma Demonstrating Isolated Loss of PMS2 Immunohistochemical Expression , 2015, The American journal of surgical pathology.

[2]  M. Kloor,et al.  Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters , 2015, PloS one.

[3]  Christopher D. Heinen,et al.  Milestones of Lynch syndrome: 1895–2015 , 2015, Nature Reviews Cancer.

[4]  C. Boland,et al.  Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case , 2015, Familial Cancer.

[5]  Rodney J Scott,et al.  Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database , 2013, Nature Genetics.

[6]  Aung Ko Win,et al.  Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. , 2013, Journal of the National Cancer Institute.

[7]  Axel Benner,et al.  Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. , 2012, The Lancet. Oncology.

[8]  Aung Ko Win,et al.  Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry , 2012, Modern Pathology.

[9]  C. Boland,et al.  Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps , 2012, Cancer Prevention Research.

[10]  Laetitia Huiart,et al.  Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. , 2011, JAMA.

[11]  K. Romans,et al.  Rapid development of colorectal neoplasia in patients with Lynch syndrome. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[12]  D. Ahnen.  The American College of Gastroenterology Emily Couric Lecture—The Adenoma–Carcinoma Sequence Revisited: Has the Era of Genetic Tailoring Finally Arrived? , 2011, The American Journal of Gastroenterology.

[13]  L. Kiemeney,et al.  Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers , 2010, Journal of Medical Genetics.

[14]  Bhramar Mukherjee,et al.  Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. , 2009, Gastroenterology.

[15]  F. Nagengast,et al.  In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response , 2009, Histopathology.

[16]  Mari Mino-Kenudson,et al.  Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. , 2009, The Journal of molecular diagnostics : JMD.

[17]  Heather Hampel,et al.  Feasibility of screening for Lynch syndrome among patients with colorectal cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  J. Shia.  Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. , 2008, The Journal of molecular diagnostics : JMD.

[19]  H. Vasen.  Review article: the Lynch syndrome (hereditary nonpolyposis colorectal cancer) * , 2007, Alimentary pharmacology & therapeutics.

[20]  Esa Läärä,et al.  Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome. , 2007, Gastroenterology.

[21]  J. Douglas,et al.  History and molecular genetics of Lynch syndrome in family G: a century later. , 2005, JAMA.

[22]  A. Lindblom,et al.  Loss of mismatch repair protein immunostaining in colorectal adenomas from patients with hereditary nonpolyposis colorectal cancer , 2005, Modern Pathology.

[23]  W. Frankel,et al.  Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). , 2005, The New England journal of medicine.

[24]  M. Kloor,et al.  Microsatellite analysis of hereditary nonpolyposis colorectal cancer-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein expression provides new insights in early steps of tumorigenesis. , 2005, The Journal of molecular diagnostics : JMD.

[25]  P. Eilers,et al.  The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC. , 2004, Gastroenterology.

[26]  H. Hollema,et al.  Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation , 2002, Gut.

[27]  E. Jaramillo,et al.  Adenoma prevalence and cancer risk in familial non-polyposis colorectal cancer , 2002, Gut.

[28]  B. Leggett,et al.  DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer , 2000, Gut.

[29]  L. Kiemeney,et al.  Urinary tract cancer and hereditary nonpolyposis colorectal cancer: risks and screening options. , 1998, The Journal of urology.

[30]  L. Aaltonen,et al.  Life‐time risk of different cancers in hereditary non‐polyposis colorectal cancer (hnpcc) syndrome , 1995, International journal of cancer.

[31]  C. Boland,et al.  Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. , 1995, Journal of the National Cancer Institute.

[32]  G. Miller.  Carcinoma of the Colon and Rectum. , 1942, Canadian Medical Association journal.