Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins - eScholarship

Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual geno

[1]  J Alter,et al.  Progress and Promise , 1919, Nature.

[2]  T. Taniguchi,et al.  Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage , 1996, Nature.

[3]  Chris Sander,et al.  Characterizing gene sets with FuncAssociate , 2003, Bioinform..

[4]  G. Collins The next generation. , 2006, Scientific American.

[5]  R. Tibbetts,et al.  Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli , 2006, Science.

[6]  W. Pear,et al.  Impaired notch signaling promotes de novo squamous cell carcinoma formation. , 2006, Cancer research.

[7]  J. Rogers,et al.  hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes , 2007, Genomics.

[8]  A. Vazquez,et al.  Epstein–Barr virus and virus human protein interaction maps , 2007, Proceedings of the National Academy of Sciences.

[9]  S. V. Vande Pol,et al.  Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein. , 2007, Virology.

[10]  S. Smola,et al.  Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding. , 2009, The Journal of general virology.

[11]  N. Hacohen,et al.  A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection , 2009, Cell.

[12]  D. Livingston,et al.  Small DNA tumor viruses: large contributors to biomedical sciences. , 2009, Virology.

[13]  P. Bork,et al.  A method and server for predicting damaging missense mutations , 2010, Nature Methods.

[14]  N. Copeland,et al.  Harnessing transposons for cancer gene discovery , 2010, Nature Reviews Cancer.

[15]  Derek Y. Chiang,et al.  The landscape of somatic copy-number alteration across human cancers , 2010, Nature.

[16]  Teri A Manolio,et al.  Genomewide association studies and assessment of the risk of disease. , 2010, The New England journal of medicine.

[17]  S. Ficarro,et al.  Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage. , 2010, Journal of proteome research.

[18]  David E Hill,et al.  High-quality binary interactome mapping. , 2010, Methods in enzymology.

[19]  M. Calderwood,et al.  Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. , 2011, Virology.

[20]  A. Barabasi,et al.  Interactome Networks and Human Disease , 2011, Cell.

[21]  David E Hill,et al.  next-generation sequencing to generate interactome datasets , 2011 .

[22]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[23]  M. Stratton Exploring the Genomes of Cancer Cells: Progress and Promise , 2011, Science.

[24]  S. Srinivasula,et al.  Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation , 2011, Proceedings of the National Academy of Sciences.

[25]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[26]  A. Capobianco,et al.  Notch signalling in solid tumours: a little bit of everything but not all the time , 2011, Nature Reviews Cancer.

[27]  T. Suda,et al.  Faculty Opinions recommendation of A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. , 2011 .

[28]  A. Iwasaki,et al.  Genome–virome interactions: examining the role of common viral infections in complex disease , 2011, Nature Reviews Microbiology.

[29]  A. Wallberg,et al.  Cutaneous Papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling , 2011, Oncogene.

[30]  Deok-Sun Lee,et al.  Viral Perturbations of Host Networks Reflect Disease Etiology , 2012, PLoS Comput. Biol..