The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

[1]  S. Sayyahfar,et al.  Association of vitamin D and severity of COVID-19 in children , 2022, European journal of translational myology.

[2]  A. Diyya,et al.  Multiple Micronutrient Supplementation: As a Supportive Therapy in the Treatment of COVID-19 , 2022, BioMed research international.

[3]  Bo Zhou,et al.  Prooxidative inhibition against NF-κB-mediated inflammation by pharmacological vitamin C , 2022, Free Radical Biology and Medicine.

[4]  B. Guidet,et al.  Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients , 2021, Critical Care.

[5]  S. Lin,et al.  The role of vitamin C in pneumonia and COVID-19 infection in adults with European ancestry: a Mendelian randomisation study , 2021, European Journal of Clinical Nutrition.

[6]  J. Kang,et al.  The Anti-Inflammatory Effect of Aptamin C on House Dust Mite Extract-Induced Inflammation in Keratinocytes via Regulation of IL-22 and GDNF Production , 2021, Antioxidants.

[7]  Jae Seung Lee,et al.  The effectiveness of vitamin C for patients with severe viral pneumonia in respiratory failure , 2021, Journal of thoracic disease.

[8]  L. Nováková,et al.  Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination , 2021, Nutrients.

[9]  S. Sanaie,et al.  Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study , 2021, BMC Infectious Diseases.

[10]  M. Boskabady,et al.  The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review , 2021, Phytotherapy research : PTR.

[11]  B. Seifi,et al.  Nephroprotection through Modifying the Apoptotic TNF-α/ERK1/2/Bax Signaling Pathway and Oxidative Stress by Long-term Sodium Hydrosulfide Administration in Ovalbumin-induced Chronic Asthma , 2020, Immunological investigations.

[12]  K. Woo,et al.  Vitamins B-12 and C Supplementation Improves Arterial Reactivity and Structure in Passive Smokers: Implication in Prevention of Smoking-Related Atherosclerosis , 2020, The journal of nutrition, health & aging.

[13]  Besham Kumar,et al.  The Role of Vitamin C as Adjuvant Therapy in COVID-19 , 2020, Cureus.

[14]  A. Singh,et al.  Study of vitamin C therapy in allergic rhinitis , 2020, International Journal of Otorhinolaryngology and Head and Neck Surgery.

[15]  Bo Han,et al.  Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection , 2020, Journal of Global Antimicrobial Resistance.

[16]  A. Zhitkovich.  Nuclear and Cytoplasmic Functions of Vitamin C , 2020, Chemical research in toxicology.

[17]  Habiba I. Ali,et al.  Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? , 2020, Maturitas.

[18]  B. Seifi,et al.  An overview of high-mobility group box 1, a potent pro-inflammatory cytokine in asthma , 2020, Journal of basic and clinical physiology and pharmacology.

[19]  Jing Zhang,et al.  Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial , 2020, BMJ Open.

[20]  W. Labaki,et al.  Chronic respiratory diseases: a global view. , 2020, The Lancet. Respiratory medicine.

[21]  B. Karwowski,et al.  Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent , 2020, Nutrients.

[22]  Stephan C. Bischoff,et al.  ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection , 2020, Clinical Nutrition.

[23]  C. Rivas,et al.  Therapeutic Use of Vitamin C in Cancer: Physiological Considerations , 2020, Frontiers in Pharmacology.

[24]  Yuping Liao,et al.  Combined treatment with hydrocortisone, vitamin C, and thiamine for sepsis and septic shock (HYVCTTSSS): A randomized controlled clinical trial. , 2020, Chest.

[25]  B. Seifi,et al.  Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma , 2020, Pharmaceutical biology.

[26]  P. Marik,et al.  The antiviral properties of vitamin C , 2019, Expert review of anti-infective therapy.

[27]  B. Seifi,et al.  Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation , 2019, Respiratory Physiology & Neurobiology.

[28]  B. Seifi,et al.  Protective effects of hydrogen sulfide on anxiety in ovalbumin-induced chronic asthma , 2019 .

[29]  H. S. Erol,et al.  The Protection Potential of Antioxidant Vitamins Against Acute Respiratory Distress Syndrome: a Rat Trial , 2019, Inflammation.

[30]  E. Beller,et al.  Oral vitamin C supplements to prevent and treat acute upper respiratory tract infections , 2019, Cochrane Database of Systematic Reviews.

[31]  Wael M Elsaed,et al.  Attenuation of lipopolysaccharide-induced lung inflammation by ascorbic acid in rats: Histopathological and ultrastructural study , 2019, SAGE open medicine.

[32]  P. Marik.  Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid , 2018, Nutrients.

[33]  J. Pullar,et al.  Vitamin C and immune cell function in inflammation and cancer , 2018, Biochemical Society transactions.

[34]  T. Mickleborough,et al.  Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. , 2018, Asian Pacific journal of allergy and immunology.

[35]  M. Vissers,et al.  Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence , 2018, Front. Physiol..

[36]  A. Hagel,et al.  Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study , 2018, The Journal of international medical research.

[37]  A. Caughey,et al.  Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma , 2018, Journal of Perinatology.

[38]  M. Mazer-Amirshahi,et al.  Vitamin C: The next step in sepsis management? , 2018, Journal of critical care.

[39]  P. Marik,et al.  Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide‐Induced Pulmonary Endothelial Barrier Dysfunction , 2017, Chest.

[40]  Mi Hye Song,et al.  Vitamin C enhances the expression of IL17 in a Jmjd2–dependent manner , 2017, BMB reports.

[41]  H. J. Kim,et al.  Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012 , 2016, International journal of chronic obstructive pulmonary disease.

[42]  K. Panda,et al.  Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis , 2016, Proceedings of the National Academy of Sciences.

[43]  Miguel J. Berdiel,et al.  High dose intravenous vitamin c treatment in a patient with lung cancer: A case report , 2016, Clinical case reports and reviews.

[44]  Ruijin Li,et al.  Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. , 2016, Chemosphere.

[45]  N. Rajab,et al.  Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients. , 2016, Journal of nutritional science and vitaminology.

[46]  H. Iwahashi,et al.  Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles , 2015, Journal of occupational health.

[47]  S. Ganguly,et al.  Causation of cigarette smoke-induced emphysema by p-benzoquinone and its prevention by vitamin C. , 2015, American journal of respiratory cell and molecular biology.

[48]  H. Hemilä.  The effect of vitamin C on bronchoconstriction and respiratory symptoms caused by exercise: a review and statistical analysis , 2014, Allergy, Asthma & Clinical Immunology.

[49]  Jie Luo,et al.  Association between vitamin C intake and lung cancer: a dose-response meta-analysis , 2014, Scientific Reports.

[50]  H. O. Oudemans-van Straaten,et al.  Vitamin C revisited , 2014, Critical Care.

[51]  N. Arora,et al.  Intranasal administration of a combination of choline chloride, vitamin C, and selenium attenuates the allergic effect in a mouse model of airway disease. , 2014, Free radical biology & medicine.

[52]  T. Hirai,et al.  Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration. , 2013, American journal of respiratory cell and molecular biology.

[53]  A. Fowler,et al.  Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis , 2014, Journal of Translational Medicine.

[54]  Yulin Liao,et al.  XB130 promotes proliferation and invasion of gastric cancer cells , 2014, Journal of Translational Medicine.

[55]  H. Hemilä.  Vitamin C and common cold-induced asthma: a systematic review and statistical analysis , 2013, Allergy, Asthma & Clinical Immunology.

[56]  A. Moody,et al.  Effects of hyperoxia on the permeability of 16HBE14o– cell monolayers – the protective role of antioxidant vitamins E and C , 2013, The FEBS journal.

[57]  B. Das,et al.  Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells. , 2013, Toxicology letters.

[58]  A. Carr,et al.  The bioavailability of vitamin C from kiwifruit. , 2013, Advances in food and nutrition research.

[59]  A. Moody,et al.  Hyperoxia-induced ciliary loss and oxidative damage in an in vitro bovine model: the protective role of antioxidant vitamins E and C. , 2012, Biochemical and biophysical research communications.

[60]  Arunava Ghosh,et al.  Molecular and Cellular Mechanisms of Cigarette Smoke-Induced Myocardial Injury: Prevention by Vitamin C , 2012, PloS one.

[61]  K. Ward,et al.  Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[62]  N. Høiby,et al.  Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigs. , 2012, Basic & clinical pharmacology & toxicology.

[63]  M. Alkhateeb,et al.  Potential roles for vitamins E and C in combination in modulation against exhaustive swimming‐and high altitude‐associated lung injury in rats , 2012, Saudi medical journal.

[64]  R. Russell,et al.  Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets. , 2012, Lung cancer.

[65]  Doaa A. Sourour,et al.  Protective Effects of Vitamin C Against Benzene-Induced Lung Injury in Rats , 2012 .

[66]  J. Kamel,et al.  Protective effects of vitamin C against haematological and biochemical toxicity induced by deltamethrin in male Wistar rats. , 2011, Ecotoxicology and environmental safety.

[67]  Á. Tósaki,et al.  Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in Suppression of respiratory inflammation: a comparison with ibuprofen , 2011, Phytotherapy research : PTR.

[68]  W. Lee,et al.  Mega-dose vitamin C attenuated lung inflammation in mouse asthma model , 2010, Anatomy & cell biology.

[69]  R. Fukushima,et al.  Vitamin C requirement in surgical patients , 2010, Current opinion in clinical nutrition and metabolic care.

[70]  M. Espey,et al.  Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects , 2010, PloS one.

[71]  Y. Cho,et al.  The Role of Oxidative Stress in the Pathogenesis of Asthma , 2010, Allergy, asthma & immunology research.

[72]  R. Locksley,et al.  Asthma and Allergic Inflammation , 2010, Cell.

[73]  H. Redl,et al.  Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. , 2010, Cell stem cell.

[74]  C. Chen,et al.  High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice. , 2009, Journal of agricultural and food chemistry.

[75]  Siddhartha Roy,et al.  Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C , 2008, Journal of Inflammation.

[76]  E. H. Terzi,et al.  The effects of N-acetylcysteine and vitamin C on liver and pulmonary tissue damage in rats following bile duct ligation. , 2008, Saudi medical journal.

[77]  A. Hemmati,et al.  Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat , 2008, Inflammopharmacology.

[78]  E. White,et al.  Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. , 2008, American journal of respiratory and critical care medicine.

[79]  P. McCrory.  Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma , 2008 .

[80]  T. Mickleborough,et al.  Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. , 2007, Respiratory medicine.

[81]  Tzu-chin Wu,et al.  Vitamin E and vitamin C supplementation in patients with chronic obstructive pulmonary disease. , 2007, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[82]  M. Javorka,et al.  The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy. , 2006, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[83]  Silvia Maggini,et al.  Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions , 2006, Annals of Nutrition and Metabolism.

[84]  M. Pringle,et al.  Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. , 2006, Respiratory medicine.

[85]  Harri Hemilä,et al.  Vitamin C for Preventing and Treating the Common Cold , 2005, PLoS medicine.

[86]  W. Lee,et al.  Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation. , 2005, Immunology letters.

[87]  M. Stampfer,et al.  Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. , 2004, Journal of the American Society of Nephrology : JASN.

[88]  A. P. Duntau,et al.  Ascorbic acid in blood serum of patients with pulmonary tuberculosis and pneumonia. , 2004, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[89]  M. Boskabady,et al.  Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs , 2003, Respirology.

[90]  M. Pringle,et al.  Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo‐controlled trial , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[91]  D. Golde,et al.  Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. , 2003, Blood.

[92]  Peter Eck,et al.  Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention , 2003, Journal of the American College of Nutrition.

[93]  S. Schueler,et al.  Do vitamins C and E attenuate the effects of reactive oxygen species during pulmonary reperfusion and thereby prevent injury? , 2002, Annals of Thoracic Surgery.

[94]  C. Cross,et al.  Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. , 2002, Toxicology.

[95]  C. Johnston,et al.  Plasma-Saturating Intakes of Vitamin C Confer Maximal Antioxidant Protection to Plasma , 2001, Journal of the American College of Nutrition.

[96]  K. Rabe,et al.  Pharmacological treatment of asthma today , 2001, European Respiratory Journal.

[97]  E. Nanba,et al.  Regulation of Cigarette Smoke-Induced Cytochrome P4501A1 Gene Expression in Osteogenic Disorder Shionogi Rat Liver and in Lung by Large Ascorbic Acid Dose , 2001, Bioscience, biotechnology, and biochemistry.

[98]  H. Schäfers,et al.  Ascorbic acid for amelioration of reperfusion injury in a lung autotransplantation model in sheep. , 2000, Annals of Thoracic Surgery.

[99]  J. Burdon.  Is this chronic asthma? , 2000, Australian family physician.

[100]  K. Panda,et al.  Vitamin C prevents cigarette smoke-induced oxidative damage in vivo. , 2000, Free radical biology & medicine.

[101]  N. Riordan,et al.  Clinical and Experimental Experiences with Intravenous Vitamin C , 2000 .

[102]  T. Litovitz,et al.  1998 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 2005, The American journal of emergency medicine.

[103]  L. Ausman.  Criteria and recommendations for vitamin C intake. , 1999, Nutrition reviews.

[104]  A. Carr,et al.  Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. , 1999, The American journal of clinical nutrition.

[105]  A. Leahy,et al.  Vitamin C reduces ischaemia-reperfusion-induced acute lung injury. , 1999, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[106]  J. B. Park,et al.  Criteria and recommendations for vitamin C intake. , 1999, JAMA.

[107]  H. Hemilä.  Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. , 1999, Medical hypotheses.

[108]  Z. S. Ercan,et al.  The mechanism of the relaxing effect of ascorbic acid in guinea pig isolated tracheal muscle. , 1997, General pharmacology.

[109]  J. Salonen,et al.  Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation , 1997, European Journal of Clinical Nutrition.

[110]  H. Hemilä.  Vitamin C and Common Cold Incidence: A Review of Studies with Subjects Under Heavy Physical Stress , 1996, International journal of sports medicine.

[111]  G. Maritz.  Ascorbic acid. Protection of lung tissue against damage. , 1996, Sub-cellular biochemistry.

[112]  K. Quesenberry.  Guinea pigs. , 2021, The Veterinary clinics of North America. Small animal practice.

[113]  T. Litovitz,et al.  1998 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 1999, The American journal of emergency medicine.

[114]  C. Schorah,et al.  The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. , 1994, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[115]  C. Bucca,et al.  Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. , 1990, Annals of allergy.

[116]  J. Douglas,et al.  Airway responsiveness and prostaglandin generation in scorbutic guinea pigs. , 1988, Prostaglandins, Leukotrienes and Essential Fatty Acids.

[117]  R. Fraser,et al.  Effects of different levels of vitamin C intake on the vitamin C concentration in guinea pigs plasma and the effect of vitamin C intake on anaphylaxis. , 1988, Medecine interne.

[118]  P. Wyde,et al.  The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus. , 1988, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[119]  R. Anderson,et al.  Ascorbic acid in bronchial asthma. , 1983, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[120]  P. R. Miles,et al.  Ascorbate uptake by isolated rat alveolar macrophages and type II cells. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[121]  S. Yung,et al.  Ascorbic acid absorption in humans: a comparison among several dosage forms. , 1982, Journal of pharmaceutical sciences.

[122]  C. Anah,et al.  High dose ascorbic acid in Nigerian asthmatics. , 1980, Tropical and geographical medicine.

[123]  C. Kurahara,et al.  The effect of variations in vitamin C intake on the cellular immune response of guinea pigs. , 1980, The American journal of clinical nutrition.

[124]  C. Kurahara,et al.  Cell-mediated cytotoxicity and humoral immune response in ascorbic acid-deficient guinea pigs. , 1979, American Journal of Clinical Nutrition.

[125]  E. Žuškin,et al.  Inhibition of histamine-induced airway constriction by ascorbic acid. , 1973, The Journal of allergy and clinical immunology.

[126]  B. Hemsworth,et al.  Actions of sodium ascorbate on smooth muscle. , 1967, British journal of pharmacology and chemotherapy.

[127]  D. Shanklin,et al.  Ascorbic Acid and the Lung , 1966, Nature.

[128]  A. Sabin.  VITAMIN C IN RELATION TO EXPERIMENTAL POLIOMYELITIS : WITH INCIDENTAL OBSERVATIONS ON CERTAIN MANIFESTATIONS IN MACACUS RHESUS MONKEYS ON A SCORBUTIC DIET , 1939 .