The Skn 7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae factors , Yap 1 and Yap 2 , was found to confer resistance

factors, Yap1 and Yap2, was found to confer resistance Brian A.Morgan1,2, Geoffrey R.Banks1, to a wide range of drugs and oxidizing agents (MoradasW.Mark Toone1,4, Desmond Raitt1, Ferreira et al., 1996). Yap1 and Yap2 are members of Shusuke Kuge3 and Leland H.Johnston1,5 the c-jun family of proteins which constitute part of 1Division of Yeast Genetics, National Institute for Medical Research, the AP1 transcription factor of higher eukaryotes. Both The Ridgeway, Mill Hill, London NW7 1AA, 2Department of Yap1 and Yap2 contain a basic leucine zipper domain Biochemistry and Genetics, Medical School, University of Newcastle, (bZIP) adjacent to a DNA binding domain located at Newcastle-upon-Tyne NE2 4HH, UK and 3Institute of Medical the N-terminus of the proteins. Null mutants of both Sciences, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan YAP1 and YAP2 result in sensitivity of S.cerevisiae to 4Present address: Imperial Cancer Research Fund, 44 Lincoln’s Inn the oxidizing agent hydrogen peroxide (Stephen et al., Fields, London WC2A 3PX, UK 1995). Further, Yap1 binds directly to the promoter, 5Corresponding author and regulates the expression of the TRX2 gene (Kuge