Consideration of the probative value of single donor 15-plex STR profiles in UK populations and its presentation in UK courts.

The adoption of new 15 locus STR multiplex systems into UK forensic science would be facilitated by agreed guidelines for reporting the strength of DNA evidence using likelihood ratios. To facilitate such an agreement, we present an analysis of previously published UK allele frequencies for white Caucasian, Afro-Caribbean and Indo-Pakistani populations and investigate their effect on likelihood ratios for single donor profiles. We consider the implication of the five additional loci and suggest a procedure for reporting likelihood ratios for 15-plex STR profiles.

[1]  I. Evett,et al.  A hierarchy of propositions: deciding which level to address in casework , 1998 .

[2]  Niels Morling,et al.  New multiplexes for Europe-amendments and clarification of strategic development. , 2006, Forensic science international.

[3]  J. Buckleton,et al.  The effect of linkage on the calculation of DNA match probabilities for siblings and half siblings. , 2006, Forensic science international.

[4]  D J Balding,et al.  DNA profile match probability calculation: how to allow for population stratification, relatedness, database selection and single bands. , 1994, Forensic science international.

[5]  Á. Carracedo,et al.  Analysis of global variability in 15 established and 5 new European Standard Set (ESS) STRs using the CEPH human genome diversity panel. , 2011, Forensic science international. Genetics.

[6]  J. Curran,et al.  Empirical support for the reliability of DNA interpretation in Croatia. , 2008, Forensic science international. Genetics.

[7]  Niels Morling,et al.  The evolution of DNA databases--recommendations for new European STR loci. , 2006, Forensic science international.

[8]  J. Buckleton,et al.  Forensic DNA Evidence Interpretation , 2004 .

[9]  David H. Kaye.  Trawling DNA Databases for Partial Matches: What is the FBI Afraid of? , 2009 .

[10]  B S Weir,et al.  Estimating F-statistics. , 2002, Annual review of genetics.

[11]  J. Butler,et al.  Linkage disequilibrium analysis of D12S391 and vWA in U.S. population and paternity samples. , 2011, Forensic science international. Genetics.

[12]  J. Curran,et al.  Relatedness calculations for linked loci incorporating subpopulation effects. , 2013, Forensic science international. Genetics.

[13]  Niels Morling,et al.  Analysis of matches and partial-matches in a Danish STR data set. , 2012, Forensic science international. Genetics.

[14]  James M Curran,et al.  How reliable is the sub-population model in DNA testimony? , 2006, Forensic science international.

[15]  J. Buckleton,et al.  An evaluation of potential allelic association between the STRs vWA and D12S391: implications in criminal casework and applications to short pedigrees. , 2012, Forensic science international. Genetics.

[16]  John Buckleton,et al.  Interpreting low template DNA profiles. , 2009, Forensic science international. Genetics.

[17]  J. Curran,et al.  Empirical support for the reliability of DNA evidence interpretation in Australia and New Zealand , 2008 .

[18]  Madhuri S. Mulekar,et al.  Weight-of Evidence for Forensic DNA Profiles , 2008, Technometrics.

[19]  P. Gill,et al.  The recombination landscape around forensic STRs: Accurate measurement of genetic distances between syntenic STR pairs using HapMap high density SNP data. , 2012, Forensic science international. Genetics.

[20]  John Buckleton,et al.  Empirical testing of estimated DNA frequencies. , 2007, Forensic science international. Genetics.

[21]  Bruce S Weir,et al.  Matching and partially-matching DNA profiles. , 2004, Journal of forensic sciences.

[22]  James M Curran,et al.  An investigation into the performance of methods for adjusting for sampling uncertainty in DNA likelihood ratio calculations. , 2011, Forensic science international. Genetics.

[23]  I. Evett,et al.  Interpreting DNA Evidence: Statistical Genetics for Forensic Scientists , 1998 .

[24]  Corrigendum to “Linkage disequilibrium analysis of D12S391 and vWA in U.S. population and paternity samples” [Forensic Sci. Int.: Genet. (in press), doi:10.1016/j.fsigen.2010.09.003] , 2011 .

[25]  B Devlin,et al.  On the probability of matching DNA fingerprints. , 1992, Science.

[26]  Ian W. Evett,et al.  Large scale database experiments to assess the significance of matching DNA profiles , 2005, International Journal of Legal Medicine.

[27]  Bruce Budowle,et al.  Population genetic analyses of the NGM STR loci , 2010, International Journal of Legal Medicine.

[28]  I. W. Evett,et al.  Statistical analyses to support forensic interpretation for a new ten-locus STR profiling system , 2001, International Journal of Legal Medicine.