Frequency of hepatitis C virus genotypes in infected patients in Charmahal-O-Bakhtiari Province, Iran

In Iran, limited information exists on the epidemiology of hepatitis C virus (HCV) genotypes in different districts of the country. In Charmahal-O-Bakhtiari Province, there was no datum on the mentioned issue. In this study, serum samples were collected from 80 clinical patients (suspected to have HCV infection between 2009 and 2010) and tested in a laboratory in Hajar Hospital of Shahre-Kord, Charmahal-O-Bakhtiari Province, Iran; they were analyzed for HCV ribonucleic acid (RNA). The most frequently found genotype was genotype 3a, present in 11 to 17 (64.7%) patients, followed by genotype 1a. In conclusion, the most frequent HCV genotype in Shahre-Kord was 3a, which was different from that of Iran’s general population, an indication that the epidemiology of HCV infection in the region is drug abuse predominated. More studies are needed to confirm this conclusion. Key words: Hepatitis C virus genotyping, Iran, epidemiology.

[1]  M. Makvandi,et al.  Determination of hepatitis C virus genotypes among blood donors in Ahvaz, Iran. , 2010, Indian journal of medical microbiology.

[2]  S. Zarkesh-Esfahani,et al.  Hepatitis C virus genotype frequency in Isfahan province of Iran: a descriptive cross-sectional study , 2010, Virology Journal.

[3]  D. Mehrabani,et al.  HEPATITIS C VIRUS GENOTYPE DISTRIBUTION IN SHIRAZ, SOUTHERN IRAN , 2009 .

[4]  S. Alavian,et al.  Distribution of Hepatitis C Virus Genotypes in Iran: A Population-Based Study , 2009 .

[5]  M. Ardalan,et al.  Hepatitis C virus genotypes in patients with end-stage renal disease in East Azerbaijan, Iran. , 2008, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.

[6]  S. Alavian.  Hepatitis C, Chronic Renal Failure, Control Is Possible! , 2006 .

[7]  R. S. Ross,et al.  Genotyping of Hepatitis C Virus Isolates using CLIP Sequencing , 2000, Journal of Clinical Microbiology.

[8]  M. Zali,et al.  Hepatitis C virus genotypes in the Islamic Republic of Iran: a preliminary study. , 2000, Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit.

[9]  G. Davis,et al.  Factors predictive of a beneficial response to therapy of hepatitis C , 1997, Hepatology.

[10]  P. Simmonds,et al.  Hepatitis C virus (HCV) genotypes and chronic liver disease in Pakistan , 1997, Journal of gastroenterology and hepatology.

[11]  P. Simmonds,et al.  The distribution of hepatitis C virus genotypes in Turkish patients , 1995, Journal of viral hepatitis.

[12]  E. Holmes,et al.  Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. , 1993, The Journal of general virology.

[13]  P. Simmonds,et al.  Detection of three types of hepatitis C virus in blood donors: investigation of type‐specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities , 1993, Transfusion.