Creutzfeldt-Jakob disease in England and Wales, 1980-1984: a case-control study of potential risk factors.

An attempt was made to ascertain all cases of Creutzfeldt-Jakob disease occurring in England and Wales during the 5 year period 1980-1984. The mean annual mortality rate was 0.49/million; women were more frequently affected than men. The age-specific mortality rate reached a peak in the seventh decade. A case-control study involving 92 of the 122 definite and probable cases ascertained failed to confirm the reality of previously suspected aetiological agents in the environment. Although there was no confirmed instance of familial Creutzfeldt-Jakob disease in the case-control study, dementia in close relatives was significantly more common than in controls.

[1]  P. Castaigne,et al.  The epidemiology of Creutzfeldt‐Jakob disease , 1987, Neurology.

[2]  R. Purcell,et al.  SEROLOGICAL RESPONSE TO THE HEPATITIS DELTA VIRUS IN HEPATITIS D , 1987, The Lancet.

[3]  P. Brown,et al.  Transmission of Creutzfeldt-Jakob disease from formalin-fixed, paraffin-embedded human brain tissue. , 1986, The New England journal of medicine.

[4]  E. Hedley‐Whyte,et al.  Neuropathologic verification of Creutzfeldt‐Jakob disease in the exhumed American recipient of human pituitary growth hormone , 1986, Neurology.

[5]  P. Smith,et al.  A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-1979. II: Epidemiology. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[6]  M. Fisman.  Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. , 1986, The New England journal of medicine.

[7]  F. Cathala,et al.  Maladie de Creutzfeldt-Jakob en France. Intérêt des formes familiales: existe-t-il un gène gouvernant la durée de l'incubation? , 1986 .

[8]  J. Parisi,et al.  Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone. , 1985, The New England journal of medicine.

[9]  P. Brown,et al.  Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. , 1985, The New England journal of medicine.

[10]  D. Gajdusek,et al.  A case-control study of Creutzfeldt-Jakob disease. Dietary risk factors. , 1985, American journal of epidemiology.

[11]  M. Preece,et al.  CREUTZFELDT-JAKOB DISEASE AFTER ADMINISTRATION OF HUMAN GROWTH HORMONE , 1985, The Lancet.

[12]  P. Brown,et al.  Creutzfeldt‐Jakob disease of long duration: Clinicopathological characteristics, transmissibility, and differential diagnosis , 1984, Annals of neurology.

[13]  R. Will,et al.  A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-79. I: Clinical features. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[14]  C. Masters,et al.  Syndromes of amyotrophic lateral sclerosis and dementia: Relation to transmissible Creutzfeldt‐Jakob disease , 1983, Annals of neurology.

[15]  L. Pickle,et al.  Information available from surrogate respondents in case-control interview studies. , 1983, American journal of epidemiology.

[16]  K. Kondo,et al.  A case control study of Creutzfeldt‐Jakob disease: Association with physical injuries , 1982, Annals of neurology.

[17]  R. Will,et al.  Evidence for case-to-case transmission of Creutzfeldt-Jakob disease , 1982, Journal of neurology, neurosurgery, and psychiatry.

[18]  M. Gail,et al.  Likelihood calculations for matched case-control studies and survival studies with tied death times , 1981 .

[19]  R. Will,et al.  CREUTZFELDT-JAKOB DISEASE IN A LIFELONG VEGETARIAN , 1981, The Lancet.

[20]  K. Tyler,et al.  Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. , 1980, The Journal of infectious diseases.

[21]  P. Brown,et al.  Creutzfeldt‐Jakob disease in France: III. Epidemiological study of 170 Patients dying during the decade 1968–1977 , 1979, Annals of neurology.

[22]  W. B. Matthews,et al.  CREUTZFELDT-JAKOB DISEASE AND FERRETS , 1979, The Lancet.

[23]  Jonathan O. Harris,et al.  Creutzfeldt‐Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering , 1979, Annals of neurology.

[24]  D. H. Adams,et al.  Transmission of agent of Creutzfeldt-Jakob disease. , 1978, British medical journal.

[25]  C. Bernoulli.  DANGER OF ACCIDENTAL PERSON-TO-PERSON TRANSMISSION OF CREUTZFELDT-JAKOB DISEASE BY SURGERY , 1977, The Lancet.

[26]  D. Webster,et al.  Letter: Creutzfeldt--Jakob disease after eating ovine brains? , 1975, The New England journal of medicine.

[27]  N. Da.  Letter: Hepatitis with hindsight. , 1974 .

[28]  A. Devoe,et al.  Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease. , 1974, The New England journal of medicine.

[29]  J. Brody,et al.  Creutzfeldt-Jakob disease: a case-control study. , 1973, American journal of epidemiology.

[30]  P. Daniel,et al.  Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee , 1968, Science.

[31]  P. Castaigne,et al.  The epidemiology of Creutzfeldt‐Jakob disease , 1987, Neurology.

[32]  P. Smith,et al.  A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-1979. II: Epidemiology , 1987 .

[33]  D. Gajdusek,et al.  Transmissible virus dementia: evaluation of a zoonotic hypothesis. , 1986, Neuroepidemiology.

[34]  M. Alpers,et al.  The Natural Incubation Period of Kuru and the Episodes of Transmission in Three Clusters of Patients , 1984 .

[35]  B. Patten,et al.  Creutzfeldt-Jakob Disease. Possible transmission to humans by consumption of wild animal brains. , 1984, The American journal of medicine.

[36]  C. Masters,et al.  Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile. , 1980, Archives of neurology.

[37]  S. Wolpert,et al.  Arteriovenous malformations of the brain. I: Current concepts and treatment. , 1980, Archives of neurology.