Distinguishes normal and early gastric cancer mucosal structures by multiphoton microscopy

The mortality rate of gastric cancer ranks second in the world. The prognosis of early gastric cancer is good, while the prognosis of advanced gastric cancer is poor. Therefore, early diagnosis of gastric cancer is the key to determining the prognosis of patients. Traditional pathological analysis takes a long time, and the results may have some subjectivity and randomness. Therefore, we propose a method for distinguishing normal and early gastric cancer sites by multiphoton microscopy combined with acridine orange rapid staining. The experimental results confirmed that multiphoton microscopy combined with acridine orange staining can effectively describe the normal microstructure of the human gastric mucosa，and these results laid the experimental foundation for the establishment of clinical diagnostic criteria for gastric cancer.

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