Excitatory nature of dopamine in the nigro-caudate pathway

SummaryInputs from the substantia nigra (SN) to the caudate nucleus (Cd) and the effects of electrophoretic dopamine on Cd neurones were studied in cats anaesthetized with pentobarbitone with intracellular techniques. Single shock electrical stimulation of the SN or the medial forebrain bundle (MFB) induced monosynaptic EPSPs in Cd neurones. Dopamine depolarized Cd neurones and chlorpromazine suppressed the SN or MFB induced EPSPs. Appropriate controls indicate that the drug effects were not artifactual. Some recorded neurones were identified by procion yellow dye injection as the medium-size intrinsic Cd neurones.

[1]  H. Kuypers,et al.  Retrograde axonal transport of horseradish peroxidase in rats forebrain. , 1974, Brain research.

[2]  P. Feltz.  Dopamine, amino acids and caudate unitary responses to nigral stimulation. , 1969, The Journal of physiology.

[3]  T. Stone,et al.  Responses of central neurones to amantadine: comparison with dopamine and amphetamine , 1975, Brain Research.

[4]  K. Fuxe,et al.  Observations on the cellular localization of dopamine in the caudate nucleus of the rat , 1964, Zeitschrift für Zellforschung und Mikroskopische Anatomie.

[5]  J D Connor,et al.  Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine , 1970, The Journal of physiology.

[6]  J. Connor.  Caudate Unit Responses to Nigral Stimuli: Evidence for a Possible Nigro-Neostriatal Pathway , 1968, Science.

[7]  U. Ungerstedt,et al.  6-Hydroxy-dopamine induced degeneration of central monoamine neurons. , 1968, European journal of pharmacology.

[8]  D. Purpura,et al.  Electrophysiological analysis of reciprocal caudato-nigral relations. , 1967, Brain research.

[9]  W. Zieglgänsberger,et al.  The influence of microelectrophoretically applied biogenic amines, cholinomimetics and procaine on synaptic excitation in the corpus striatum. , 1968, International journal of neuropharmacology.

[10]  T. Powell,et al.  The structure of the caudate nucleus of the cat: light and electron microscopy. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[11]  Lars Olson,et al.  Ascending Monoamine Neurons to the Telencephalon and Diencephalon , 1966 .

[12]  P. Feltz,et al.  Properties of caudate unitary responses to repetitive nigral stimulation. , 1969, Brain research.

[13]  W. Rall.  Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. , 1967, Journal of neurophysiology.

[14]  G. Pappas,et al.  The fine structure of the caudate nucleus of the cat , 1968, The Journal of comparative neurology.

[15]  T. Hökfelt,et al.  Electron and fluorescence microscopical studies on the nucleus caudatus putamen of the rat after unilateral lesions of ascending nigro-neostriatal dopamine neurons. , 1969, Acta physiologica Scandinavica.

[16]  S. Mori.  Some observations on the fine structure of the corpus striatum of the rat brain , 2004, Zeitschrift für Zellforschung und Mikroskopische Anatomie.

[17]  G. Bernardi,et al.  Intracellular responses of caudate neurons to brain stem stimulation. , 1970, Brain research.

[18]  J. Hedreen,et al.  Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study. , 1972, Brain research.

[19]  H. Simon,et al.  Selective degeneration of central dopaminergic systems after injection of 6-hydroxydopamine in the ventral mesencephalic tegmentum of the rat. Demonstration by the Fink-Heimer stain , 2004, Experimental Brain Research.

[20]  M B Carpenter,et al.  Nigrostriatal and nigrothalamic fibers in the rhesus monkey , 1972, The Journal of comparative neurology.

[21]  O. Hornykiewicz.  Dopamine (3-hydroxytyramine) and brain function. , 1966, Pharmacological reviews.

[22]  U. Ungerstedt.  Stereotaxic mapping of the monoamine pathways in the rat brain. , 1971, Acta physiologica Scandinavica. Supplementum.

[23]  C. Fox,et al.  The spiny neurons in the primate striatum: a Golgi and electron microscopic study. , 1972, Journal fur Hirnforschung.

[24]  N. Shimizu,et al.  Demonstration of nigro-neostriatal tract by degeneration silver method , 1973, Experimental Brain Research.

[25]  J. Eccles,et al.  Excitatory synaptic action in motoneurones , 1955, The Journal of physiology.

[26]  N. A. Buchwald,et al.  Caudate intracellular response to thalamic and cortical inputs. , 1973, Experimental neurology.

[27]  E. Kravitz,et al.  Neuronal Geometry: Determination with a Technique of Intracellular Dye Injecion , 1968, Science.

[28]  F. Bloom,et al.  Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis. , 1965, The Journal of pharmacology and experimental therapeutics.

[29]  A. Parent,et al.  The nigrostriatal pathway: a correlative study based on neuroanatomical and neurochemical criteria in the cat and the monkey. , 1969, Experimental Neurology.

[30]  D. York.  Potentiation of lumbo-sacral monosynaptic reflexes by the substantia nigra. , 1972, Experimental Neurology.

[31]  H. Fibiger,et al.  Demonstration of the nigrostriatal projection by silver staining after nigral injections of 6-hydroxydopamine. , 1973, Experimental neurology.

[32]  A. Heller,et al.  Anatomical and chemical studies of a nigro-neostriatal projection in the cat. , 1971, Brain research.

[33]  H. Nauta,et al.  Electron microscopic observations of horseradish peroxidase transported from the caudoputamen to the substantia nigra in the rat: Possible involvement of the agranular reticulum , 1975, Brain Research.

[34]  T. Powell,et al.  The site of termination of afferent fibres in the caudate nucleus. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[35]  W. Verhaart,et al.  Fiber analysis of the basal ganglia , 1950, The Journal of comparative neurology.

[36]  D. Albe-Fessard,et al.  A study of an ascending nigro-caudate pathway. , 1972, Electroencephalography and clinical neurophysiology.

[37]  G. Bernardi,et al.  Intracellular responses of caudate neurons to temporally and spatially combined stimuli. , 1973, Experimental neurology.

[38]  N. A. Buchwald,et al.  The spontaneous firing pattern of forebrain neurons. I. The effects of dopamine and non-dopamine depleting lesions on caudate unit firing patterns. , 1974, Brain research.

[39]  J. A. González-Vegas.  Antagonism of dopamine-mediated inhibition in the nigro-striatal pathway: a mode of action of some catatonia-inducing drugs. , 1974, Brain research.

[40]  J. M. Kemp.  An electron microscopic study of the termination of afferent fibres in the caudate nucleus. , 1968, Brain research.

[41]  H. Mclennan,et al.  The action of dopamine on neurones of the caudate nucleus , 1967, The Journal of physiology.

[42]  T. Hökfelt,et al.  Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: an electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system. , 1973, Brain research.

[43]  A. Siegel,et al.  Fiber connections of the temporal lobe with the corpus striatum and related structures in the cat. , 1971, Experimental neurology.

[44]  M. Sugimori,et al.  Glucose Inhibition of the Glucose-sensitive Neurone in the Rat Lateral Hypothalamus , 1974, Nature.

[45]  H. Fibiger,et al.  AXOPLASMIC TRANSPORT OF DOPAMINE IN NIGRO‐STRIATAL NEURONS 1 , 1973, Journal of neurochemistry.

[46]  W. Precht,et al.  Nigro-caudate and caudato-nigral relationship: an electrophysiological study , 1975, Brain Research.

[47]  K. Fuxe,et al.  DEMONSTRATION AND MAPPING OUT OF NIGRO-NEOSTRIATAL DOPAMINE NEURONS. , 1964, Life sciences.

[48]  T. Sourkes,et al.  Effect of amine precursors on the concentration of striatal dopamine and serotonin in cats with and without unilateral brain stem lesions. , 1967, Brain research.