The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor

TNIK has an important function in physiological activation and viral transformation of human B-cells by interacting with the TRAF6 adapter complex and mediating NF-κB and JNK signal transduction.

[1]  K. Kariya,et al.  The Traf2- and Nck-interacting Kinase as a Putative Effector of Rap2 to Regulate Actin Cytoskeleton* , 2004, Journal of Biological Chemistry.

[2]  G. Bishop,et al.  Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. , 2004, Immunity.

[3]  Christian Rosenmund,et al.  Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development , 2010, Neuron.

[4]  S. Morony,et al.  TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. , 1999, Genes & development.

[5]  E. Kremmer,et al.  TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 , 2001, The EMBO journal.

[6]  W. Hammerschmidt,et al.  Epstein–Barr virus‐mediated B‐cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor , 1998, The EMBO journal.

[7]  G. Bishop,et al.  Differential B‐lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1 , 2010, Immunological reviews.

[8]  D. Baltimore,et al.  Localization of the Major NF-κB-activating Site and the Sole TRAF3 Binding Site of LMP-1 Defines Two Distinct Signaling Motifs* , 1997, The Journal of Biological Chemistry.

[9]  Liming Wu,et al.  The C-terminal Activating Region 2 of the Epstein-Barr Virus-encoded Latent Membrane Protein 1 Activates NF-κB through TRAF6 and TAK1* , 2006, Journal of Biological Chemistry.

[10]  A. Tzankov,et al.  CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression. , 2012, The Journal of clinical investigation.

[11]  M. Rowe,et al.  The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. , 1995, Oncogene.

[12]  A. Kieser,et al.  The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. , 2008, Virology.

[13]  S. Akira,et al.  BS69, a Specific Adaptor in the Latent Membrane Protein 1-Mediated c-Jun N-Terminal Kinase Pathway , 2006, Molecular and Cellular Biology.

[14]  A. Kieser.  Signal transduction by the Epstein‐Barr virus oncogene latent membrane protein 1 (LMP1) , 2007 .

[15]  E. Kieff,et al.  Epstein–Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[16]  L. Young,et al.  Epstein–Barr virus: 40 years on , 2004, Nature Reviews Cancer.

[17]  Zhijian J. Chen,et al.  Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains , 2009, Nature.

[18]  L. Platanias.  Map kinase signaling pathways and hematologic malignancies. , 2003, Blood.

[19]  V. Godfrey,et al.  Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[20]  W. Hammerschmidt,et al.  LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2 , 1999, The EMBO journal.

[21]  S. Akira,et al.  TAK1 Is a Component of the Epstein-Barr Virus LMP1 Complex and Is Essential for Activation of JNK but Not of NF-κB* , 2006, Journal of Biological Chemistry.

[22]  G. Reynolds,et al.  Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth , 2005, Oncogene.

[23]  Sokol Haxhinasto,et al.  Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling* , 2003, Journal of Biological Chemistry.

[24]  K. Irie,et al.  TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. , 2000, Molecular cell.

[25]  W. Kolch,et al.  Epstein–Barr virus latent membrane protein‐1 triggers AP‐1 activity via the c‐Jun N‐terminal kinase cascade , 1997, The EMBO journal.

[26]  A. Kieser.  Pursuing different ‘TRADDes’: TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1 , 2008, Biological chemistry.

[27]  M. Rowe,et al.  Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-kappa B2 p100 to p52. , 2003, The Journal of biological chemistry.

[28]  B. Sugden,et al.  Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus , 1995, Journal of virology.

[29]  G. Mosialos,et al.  Epstein-Barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-κB , 1999, Oncogene.

[30]  K. Rajewsky,et al.  LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. , 2008, Blood.

[31]  U. Siebenlist,et al.  Control of lymphocyte development by nuclear factor-κB , 2005, Nature Reviews Immunology.

[32]  L. Young,et al.  The role of the CD40 pathway in the pathogenesis and treatment of cancer. , 2004, Current opinion in pharmacology.

[33]  M. Ueffing,et al.  Latent membrane protein 1 of Epstein–Barr virus mimics a constitutively active receptor molecule , 1997, The EMBO journal.

[34]  Elliott Kieff,et al.  Role of NF-κB in Cell Survival and Transcription of Latent Membrane Protein 1-Expressing or Epstein-Barr Virus Latency III-Infected Cells , 2004, Journal of Virology.

[35]  G. Reynolds,et al.  Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. , 2003, Oncogene.

[36]  D. Payan,et al.  TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton* , 1999, The Journal of Biological Chemistry.

[37]  Zhijian J. Chen,et al.  TAK1 is a ubiquitin-dependent kinase of MKK and IKK , 2001, Nature.

[38]  R. Khanna,et al.  Epstein-Barr Virus Associated Modulation of Wnt Pathway Is Not Dependent on Latent Membrane Protein-1 , 2008, PloS one.

[39]  Elliott Kieff,et al.  LMP1 TRAFficking activates growth and survival pathways. , 2007, Advances in experimental medicine and biology.

[40]  W. Hammerschmidt,et al.  Latent membrane protein 1 of Epstein–Barr virus coordinately regulates proliferation with control of apoptosis , 2005, Oncogene.

[41]  C. Ware,et al.  The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family , 1995, Cell.

[42]  B. Hostager.  Roles of TRAF6 in CD40 signaling , 2007, Immunologic research.

[43]  E. Kieff,et al.  Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation , 1996, Molecular and cellular biology.

[44]  S. Akira,et al.  Elucidation of the c-Jun N-Terminal Kinase Pathway Mediated by Epstein-Barr Virus-Encoded Latent Membrane Protein 1 , 2004, Molecular and Cellular Biology.

[45]  J. Caamaño,et al.  Epstein–Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κB2 to p52 via an IKKγ/NEMO-independent signalling pathway , 2003, Oncogene.

[46]  G. Bishop,et al.  Requirement for TRAF3 in Signaling by LMP1 But Not CD40 in B Lymphocytes , 2004, The Journal of experimental medicine.

[47]  G. Mosialos,et al.  Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB. , 1999, Oncogene.

[48]  A. Kaykas,et al.  CD40 and LMP‐1 both signal from lipid rafts but LMP‐1 assembles a distinct, more efficient signaling complex , 2001, The EMBO journal.

[49]  E. Kieff,et al.  Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-κB in the absence of NF-κB essential modifier residues 133–224 or 373–419 , 2010, Proceedings of the National Academy of Sciences.

[50]  E. Kremmer,et al.  B‐cell proliferation and induction of early G1‐regulating proteins by Epstein‐Barr virus mutants conditional for EBNA2. , 1995, The EMBO journal.

[51]  Hans Clevers,et al.  The kinase TNIK is an essential activator of Wnt target genes , 2009, The EMBO journal.

[52]  Zhijian J. Chen,et al.  Ubiquitin-mediated activation of TAK1 and IKK , 2007, Oncogene.

[53]  E. Kieff,et al.  The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J. Kyriakis,et al.  Signaling by the Germinal Center Kinase Family of Protein Kinases* , 1999, The Journal of Biological Chemistry.

[55]  W. Hammerschmidt,et al.  Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus. , 2003, Cancer research.

[56]  E. Kremmer,et al.  Detection of wild type and deleted latent membrane protein 1 (LMP1) of Epstein-Barr virus in clinical biopsy material. , 2004, Journal of virological methods.

[57]  M. Salmon,et al.  Differential responses to CD40 ligation among Burkitt lymphoma lines that are uniformly responsive to Epstein-Barr virus latent membrane protein 1. , 1999, Journal of immunology.

[58]  G. Courtois,et al.  Two Carboxyl-terminal Activation Regions of Epstein-Barr Virus Latent Membrane Protein 1 Activate NF-κB through Distinct Signaling Pathways in Fibroblast Cell Lines* , 2003, Journal of Biological Chemistry.

[59]  J. Ruland,et al.  Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. , 2007, Blood.

[60]  R. Brink,et al.  TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. , 2004, Immunity.

[61]  R. Longnecker,et al.  Epstein-Barr virus (EBV)-negative B-lymphoma cell lines for clonal isolation and replication of EBV recombinants , 1992, Journal of virology.

[62]  E. Kieff,et al.  The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB , 1997 .

[63]  A. Kieser,et al.  The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic Activity , 2008, PLoS biology.

[64]  M. Sandberg,et al.  Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3 , 1997, Journal of virology.

[65]  E. Kieff,et al.  Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[66]  G. Bishop,et al.  Requirement for nuclear factor-kappaB activation by a distinct subset of CD40-mediated effector functions in B lymphocytes. , 1999, Journal of immunology.

[67]  F. Bach,et al.  Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[68]  U. Siebenlist,et al.  Control of lymphocyte development by nuclear factor-kappaB. , 2005, Nature reviews. Immunology.

[69]  E. Kieff,et al.  Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[70]  S. Hirohashi,et al.  Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. , 2010, Cancer research.

[71]  Tesshi Yamada,et al.  Traf2- and Nck-interacting Kinase Is Essential for Canonical Wnt Signaling in Xenopus Axis Formation* , 2010, The Journal of Biological Chemistry.

[72]  Norinobu M. Watanabe,et al.  The Ste20 group kinases as regulators of MAP kinase cascades. , 2001, Trends in cell biology.

[73]  A. Kieser.  Assaying the activity of kinases regulated by LMP1. , 2001, Methods in molecular biology.

[74]  R. Huganir,et al.  MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function , 2010, The Journal of Neuroscience.

[75]  M. Karin,et al.  TNFR signaling: ubiquitin‐conjugated TRAFfic signals control stop‐and‐go for MAPK signaling complexes , 2009, Immunological reviews.

[76]  M. Rowe,et al.  Latent Membrane Protein 1 of Epstein-Barr Virus Stimulates Processing of NF-κB2 p100 to p52* , 2003, Journal of Biological Chemistry.