Real-Time Monitoring of Bodily Fluids Using a Novel Electromagnetic Wave Sensor

The use of a novel low power electromagnetic sensor for real-time detection of lactate in cerebrospinal fluid (CSF) is investigated. CSF holds key indicators relating to a patient’s future health. A multipurpose sensor platform is currently being developed with the capability to detect the concentration of materials in volumes =1 ml. This paper presents results from a microwave cavity resonator designed and created for this purpose, using varying concentrations of lactate in water. The work demonstrates the feasibility of monitoring bodily fluids in real-time. Such advancements are essential for improved and cost-effective delivery of healthcare services to patients.

[1]  M. B. Ewing,et al.  A highly stable cylindrical microwave cavity resonator for the measurement of the relative permittivities of gases , 2002 .

[2]  Jyh Sheen,et al.  Study of microwave dielectric properties measurements by various resonance techniques , 2005 .

[3]  L. Hansson,et al.  Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta. , 2003, Journal of cardiothoracic and vascular anesthesia.

[4]  Constantine A. Balanis,et al.  Antenna Theory: Analysis and Design , 1982 .

[5]  K. Blennow,et al.  Biomarker-based dissection of neurodegenerative diseases , 2011, Progress in Neurobiology.

[6]  R. Kuzniecky,et al.  An implantable triple-function device for local drug delivery, cerebrospinal fluid removal and EEG recording in the cranial subdural/subarachnoid space of primates , 2012, Journal of Neuroscience Methods.

[7]  Gary A. Rosenberg,et al.  Brain Edema and Disorders of Cerebrospinal Fluid Circulation , 2008 .

[8]  H. Borst,et al.  The mechanism of spinal cord injury after simple and double aortic cross-clamping. , 1986, The Journal of thoracic and cardiovascular surgery.

[9]  S. R. Wylie,et al.  RF sensor for multiphase flow measurement through an oil pipeline , 2006 .

[10]  Alex Mason,et al.  Hepa Filter Material Load Detection Using a Microwave Cavity Sensor , 2010 .

[11]  Alex Mason,et al.  Monitoring of Nitrates and Phosphates in Wastewater: Current Technologies and Further Challenges , 2012 .

[12]  Jyh Sheen,et al.  Measurements of microwave dielectric properties by an amended cavity perturbation technique , 2009 .

[13]  W. Marsden I and J , 2012 .

[14]  J. Coselli,et al.  Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair: results of a randomized clinical trial. , 2002, Journal of vascular surgery.

[15]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[16]  G. Ronquist,et al.  Central nervous system damage during cardiac surgery assessed by 3 different biochemical markers in cerebrospinal fluid. , 1992, Scandinavian journal of thoracic and cardiovascular surgery.

[17]  J. J. Choi,et al.  Three-dimensional simulations of an X-band coupled-cavity traveling-wave-tube amplifier , 2003 .

[18]  PARAMETRICS AND OPTIMIZATION USING ANSOFT HFSS , 1999 .

[19]  Ye Fang,et al.  Resonant waveguide grating biosensor for living cell sensing. , 2006, Biophysical journal.

[20]  H. Zetterberg,et al.  Cerebrospinal fluid biomarkers in neurological diseases in children. , 2013, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[21]  M. Verbeek,et al.  Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients , 2003, Brain Research Bulletin.

[22]  Stuart M. Wentworth,et al.  Fundamentals of Electromagnetics with Engineering Applications , 2004 .

[23]  D. Pozar Microwave Engineering , 1990 .

[24]  S. Frank,et al.  Changes in Cerebrospinal Fluid Pressure and Lactate Concentrations during Thoracoabdominal Aortic Aneurysm Surgery , 1997, Anesthesiology.

[25]  W. H. Elliott,et al.  Data for Biochemical Research , 1986 .

[26]  A. Mason,et al.  Dielectric Characterisation of Lipid Droplet Suspensions Using the Small Perturbation Technique , 2013 .